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L-DOPA-induced dyskinesia is a major problem in the treatment of Parkinson's disease. Today there are few anti-dyskinetic treatments available for the patients, and all of them have major limitations. Recent findings have revealed an important role of the serotonin system in L-DOPA-induced dyskinesia. In the parkinsonian brain, serotonin axon terminals can compensate for the dopamine loss by conve
The current state-of-the-art presents a multiplicity of evacuation models for simulating emergency scenarios. Each model involves different methodological solutions to represent the same process and each one has its strengths and limitations. In addition, they have their own specific features and often practitioners do not have a thorough understanding of the variables that could be input into the
In Europe, 6,000 young people die of cancer yearly, the commonest disease causing death beyond the age of 1 year. In addition, 300,000-500,000 European citizens are survivors of a childhood cancer and up to 30% of them have severe long-term sequelae of their treatment. Increasing both cure and quality of cure are the two goals of the European paediatric haematology/oncology community. SIOPE coordi
Occupational engagement is a vital factor in people's lives since it has been shown to be important for health and well-being. Community-based day centers (DCs), both meeting place-oriented and work-oriented ones, are common service alternatives in many western countries for enabling engagement in productive and leisure occupations among people with psychiatric disabilities. Little is, however, kn
Ensembles of (J,K)-regular low-density parity-check convolutional (LDPCC) codes are known to be asymptotically good, in the sense that the minimum free distance grows linearly with the constraint length. In this paper, we use a protograph-based analysis of terminated LDPCC codes to obtain an upper bound on the free distance growth rate of ensembles of periodically time-varying LDPCC codes. This bo
Diagnostic DNA analysis using polymerase chain reaction (PCR) has become a valuable tool for rapid detection of biothreat agents. However, analysis is often challenging because of the limited size, quality, and purity of the biological target. Pre-PCR processing is an integrated concept in which the issues of analytical limit of detection and simplicity for automation are addressed in all steps le
Tri-methyl-indium (TMI) is used as an indium transport molecule to introduce indium atoms to reactive hot gas flows/combustion environments for spectroscopic diagnostics. A seeding system was constructed to allow the addition of an inert TMI laden carrier gas into an air/fuel mixture burning consequently on a burner. The amount of the seeded TMI in the carrier gas can be readily varied by controll
This work proposes and demonstrates an acoustic trapping system where the trapping frequency is automatically determined and can be used to analyse changes in the acoustic trap. Critical for the functionality of this system is the use of a kerfed transducer that removes spurious resonances. This makes it possible to determine the optimal trapping frequency by analysing electrical impedance. It is
To elucidate the molecular requirements for cancer cell internalization of the extracellular cysteine protease inhibitor cystatin C, 12 variants of the protein were produced and used for uptake experiments in MCF-7 cells. Variants with alterations in the cysteine cathepsin binding region ((Δ1-10)-, K5A-, R8G-, (R8G,L9G,V10G)-, (R8G,L9G,V10G, W106G)-, and W106G-cystatin C) were internalized to a ve
Abstract in UndeterminedVehicular communication channels are characterized by a nonstationary time-frequency-selective fading process due to rapid changes in the environment. The nonstationary fading process can be characterized by assuming local stationarity for a region with finite extent in time and frequency. For this finite region, the wide-sense stationarity and uncorrelated scattering assum
Objectives This study investigated the outcome for all patients undergoing catheter valve perforation for pulmonary atresia with intact ventricular septum (PAIVS) 21 years after the first procedure at their center. Background Catheter perforation for PAIVS is now an established procedure. However, the management of the borderline right ventricle (RV) is controversial, and there may be a place for
Forest carbon cycles play an important role in efforts to understand and mitigate climate change. Large amounts of carbon (C) are stored in deep mineral forest soils, but are often not considered in accounting for global C fluxes because mineral soil C is commonly thought to be relatively stable. We explore C fluxes associated with forest management practices by examining existing data on forest C
In order to find previously unknown subgroups in biomedical data and generate testable hypotheses, visually guided exploratory analysis can be of tremendous importance. In this paper we propose a new dissimilarity measure that can be used within the Multidimensional Scaling framework to obtain a joint low-dimensional representation of both the samples and variables of a multivariate data set,
The changes in force characteristics as well as the shedding patterns for various dual sphere configurations are studied. The Reynolds numbers considered are 300, 600 and two different inflow conditions are used: steady and pulsating. The sphere formations are defined by the separation distance D-0 between the spheres and the angle between the line connecting the centres of the spheres and the mai
Informed by recent sociological debates on pharmaceuticalisation, this article examines the evolution of the current EU legal proposal on prescription drug information to patients, as well as the surrounding controversies. In 2008 the European Commission proposed the relaxation of the existing rules governing drug information provision to patients by the pharmaceutical industry. Critics of the ind
The equations of motion for a beam are derived from the three-dimensional continuum mechanical point of view. The kinematics involve bending, torsion and shearing as well as cross-sectional displacements. The transplacement of the beam from an arbitrary curved reference placement is considered. For slender beams so called tubular coordinates may be used as global coordinates in the reference place
1. The mechanisms driving nonrandom assembly patterns in plant communities have long been of interest in ecological research. Competing ecological theories predict that coexisting species may either be more functionally dissimilar than expected by chance (with functional divergence' mainly reflecting niche differentiation) or be functionally more similar than expected (with functional convergence'
In this article we describe and analyse a system for rewarding excellence in university teaching developed at the Faculty of Engineering at Lund University in Sweden. Individual teachers are rewarded for the effort they invest in the support of student learning. However, it is the organization that establishes a reward system and it does so for developmental purposes. These two purposes, individua
