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The pig is becoming an increasingly used non-primate model in experimental studies of human retinal diseases and disorders. The anatomy, size, and vasculature of the porcine eye and retina closely resemble the human counterparts, which allows for application of standard instrumentation and diagnostics used in the clinic. Despite the many reports demonstrating immunohistochemistry as a useful metho

Successful tissue engineering with the aid of a polymer scaffold offers the possibility to produce a larger construct and to mould the shape after the defect. We investigated the use of cryogelation to form protein-based scaffolds through different types of formation mechanisms; enzymatic crosslinking, chemical crosslinking, and non-covalent interactions. Casein was found to best suited for enzyma

Discusses how a series of artefacts became important for cultural processes in a Swedish IT company during a turbulent period in business - a period that was known as "the new economy".

The number of scholarly blogs on the Web is increasing. In this article, a group of researchers are asked to describe the functions that their blogs serve for them as researchers. The results show that their blogging is motivated by the possibility to share knowledge, that the blog aids creativity, and that it provides a feeling of being connected in their work as researchers. In particular, the b

Bolin K, Berggren F, Forsgren L. Lacosamide as treatment of epileptic seizures - cost utility results for Sweden. Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2009.01320.x. (c) 2010 The Authors Journal compilation (c) 2010 Blackwell Munksgaard. Objectives - To calculate cost per additional quality-adjusted life-year (QALY) for lacosamide as adjunctive treatment for patients with uncontrolled partia

Volcanic eruptions contribute to climate variability, but quantifying these contributions has been limited by inconsistencies in the timing of atmospheric volcanic aerosol loading determined from ice cores and subsequent cooling from climate proxies such as tree rings. Here we resolve these inconsistencies and show that large eruptions in the tropics and high latitudes were primary drivers of inte

To evaluate the use of activated protein C-protein C inhibitor (APC-PCI) complex levels for detection of abdominal aortic aneurysm (AAA) in patients with peripheral atherosclerotic disease (PAD). APC-PCI levels and aortic diameter evaluated in 511 PAD patients without previously known AAA followed-up concerning survival for 4.8(0.5) years. AAA was found in 13 % of patients. Aortic diameter correla

During translation, mRNA molecules are incidentally damaged, leaving the ribosome unable to reach or recognize the stop codon and thus stalled with mRNA and a potentially harmful polypeptide product attached to tRNA in the ribosomal P-site. In bacteria, a process called trans-translation has evolved, where a protein-RNA complex (smpB-tmRNA) mimicks the role of aminoacyl charged tRNA in the ribosom

The assumption that voters systematically defend the welfare state is challenged by recent research showing that parties are on average not punished and sometimes even rewarded for welfare state retrenchment. We work to understand better the micro-foundations for this finding of non-punishment by exploring individuals’ preferences over social policy. In particular, we distinguish general support f

Protein biomarker discovery and validation in current omics era are vital for healthcare professionals to improve diagnosis, detect cancers at an early stage, identify the likelihood of cancer recurrence, stratify stages with differential survival outcomes, and monitor therapeutic responses. The success of such biomarkers would have a huge impact on how we improve the diagnosis and treatment of pa

A plant bioreactor has enormous capability as a system that supports many biological activities, that is, production of plant bodies, virus-like particles (VLPs), and vaccines. Foreign gene expression is an efficient mechanism for getting protein vaccines against different human viral and nonviral diseases. Plants make it easy to deal with safe, inexpensive, and provide trouble-free storage. The b

The oxygen-atom transfer reaction catalyzed by the mononuclear molybdenum enzyme dimethyl sulfoxide reductase (DMSOR) has attracted considerable attention through both experimental and theoretical studies. We show here that this reaction is more sensitive to details of quantum mechanical calculations than what has previously been appreciated Basis sets of at least triple-zeta quality are needed to

Characteristic mode analysis provides unparalleled insights into designing high performance multiple-input multiple-output (MIMO) terminal antennas at frequencies where the antenna elements are constrained to be electrically small. Conventionally, an electrically small single-antenna utilizes the fundamental characteristic mode of the terminal chassis to obtain sufficient bandwidth while maintaini

The weighted Weiss conjecture states that the system theoretic property of weighted admissibility can be characterized by a resolvent growth condition. For positive weights, it is known that the conjecture is true if the system is governed by a normal operator; however, the conjecture fails if the system operator is the unilateral shift on the Hardy space (discrete time) or the right-shift semigro

This work demonstrates the capacity of a ballistic imaging instrument to suppress diffuse photons and improve image contrast, making it possible to view fluid structure in a spray where a fog of droplets occludes the near field. Analysis of the system is performed by means of a numerical system model. The model simulates light propagation and scattering in the measurement volume using a Monte Carl

Complex computational experiments in Systems Biology, such as fitting model parameters to experimental data, can be challenging to perform. Not only do they frequently require a high level of computational power, but the software needed to run the experiment needs to be usable by scientists with varying levels of computational expertise, and modellers need to be able to obtain up-to-date experimen