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We describe a test which uses the ability of viable cells to reduce 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) to detect resistance to a bactericidal drug, rifampin, in in vitro-cultured Mycobacterium tuberculosis. The assay shows a linear relationship between the number of viable bacteria and the ability to reduce MTT. Dead mycobacteria were unable to reduce MTT. Rifampin
A mathematical model is presented for calculating heat release rate in the Room Corner Test, where lining materials are mounted on both walls and ceiling. The model is based on a thermal theory for concurrent flow flame spread. By using a simple mathematical representation of the heat release rate from the Cone Calorimeter, analytical solutions are arrived at for the velocity and position of the p
This paper explores the technical feasibility of five Advanced Driver Assistance System (ADAS) functions to contribute to road traffic safety, to reach stated European (EU) and national road traffic safety targets. These functions - enhanced navigation, speed assistance, collision avoidance, intersection support and lane keeping - were selected from previous research as adequate substitutes for in
The preliminary results from the RISING Stopped Beam Isomer Campaign are presented, with specific focus on results of the initial experiment to investigate isomeric decays along the N=Z line around A similar to 80-90 following the projectile fragmentation of a Ag-107 primary beam at an energy of 750 MeV per nucleon. A description of the technical aspects behind the design of the RISING array is pr
PURPOSE: To describe a component-based aortomonoiliac stent-graft system and the first clinical results achieved with this device in endovascular abdominal aortic aneurysm (AAA) repair. METHODS: From November 1993 to October 1996, 45 patients aged 60 to 86 years underwent endoluminal exclusion of true AAAs (median diameter 60 mm) involving the common iliac arteries (median diameter 16 mm right and
This paper describes the development and optimization of an amperometric biosensor for monitoring ethanol in beverages. The biosensor is constructed by cross-linking a quinoprotein alcohol dehydrogenase (QH-ADH) to an Os-complex-modified poly(vinylimidazole) redox polymer using poly(ethylene glycol) diglycidyl ether. The optimum biosensor configuration was evaluated by changing the ratio between e
Popular Abstract in Swedish Denna avhandling behandlar den process där man beräknar undervattensströmmar från ljud som reflekteras från en utsänd ljudpuls, precis som när en fladdermus bedömer omgivningen genom att lyssna på ekot. En ton skickas ut under en kort tid, och det Dopplerskift som uppkommer från rörliga föremål i vattnet kan sedan omsättas till vattenhastiget eller ström. Föremål som röThis thesis deals with the process of estimating underwater current from the backscattering signal transmitted from an ultrasonic transducer. The narrowband sinusoidal burst signal is Doppler-shifted due to the current, and this information is converted into current. The traditional mathematical model for this Doppler process is based on the assumption that the backscattering time signal is Gaussi
The COST/IWA benchmark simulation model has been available for seven years. Its primary purpose has been to create a platform for control strategy benchmarking of biological wastewater treatment processes. The fact that the benchmark has resulted in more than 100 publications, not only in Europe but also worldwide, demonstrates the interest for such a tool in the research community. In this paper,
The aim of this paper is to propose a framework for the evaluation of policy instruments designed to affect development and dissemination of new energy technologies. The evaluation approach is based on the analysis of selected outcome indicators describing the process of technical change, i.e. the development and dissemination of new energy technologies, on the basis of a socio-technical systems a
Aim: To investigate whether there is any pharmacokinetic rationale for the common practice of administering vincristine to adolescents at relatively lower doses than those to younger children. Methods: A total of 98 children, aged 1.3-17.3 y, with acute lymphoblastic leukaemia (ALL) were studied on day I of induction therapy. Plasma samples were drawn before and 10, 30, 360 and 1380 min after inje
Although pharmacological treatments can help alleviate mood symptoms in youth with paediatric bipolar disorder (PBD), residual symptoms still commonly persist. In many cases, these symptoms seriously affect the social and psychological development of children and adolescents suffering from PBD. Complementary interventions, such as psychosocial and psychoeducational treatments, can help children an
The role of dendritic cells (DCs) in intestinal immune homeostasis remains incompletely defined. Here we show that mice lacking IRF8 transcription-factor-dependent DCs had reduced numbers of T cells in the small intestine (SI), but not large intestine (LI), including an almost complete absence of SI CD8αβ+ and CD4+CD8αα+ T cells; the latter requiring β8 integrin expression by migratory IRF8 depend
Objective Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3′ UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. However, prior studies, emphasizing particular subgroups, were relatively small. Therefore, we comprehensively evaluated ovarian and breast canc
Models to predict chloride ingress are numerous but all of them have serious limitations that restrict the present use for long term predictions. An overview is given of the fundamental differences between various models, from those based on Fick's 2nd with constant or time-dependent diffusion coefficients and surface chloride contents, to those based on chloride transport equations with or withou
This article presents the addition of camber to a previously published semi-empirical tyre model by the same authors. The model combines empirical models for pure braking, cornering and cambering with a model for simultaneous braking, cornering and cambering. It is based on brush-model tyre mechanics and aims to offer an easy-to-use accurate model for vehicle-handling simulations. The proposed mod
This paper presents a method for modeling and control of a piezo-actuated high-dynamic compensation mechanism (HDCM) for usage together with an industrial robot during a machining operation, such as milling in aluminum. The spindle is attached to the compensation mechanism and the robot holds the workpiece. Due to the inherent resonant character of mechanical constructions of this type, and the no
Materials having bimodal grain structures are known for the good balance of strength and ductility. However, methods for their fabrication often lack the control of such structure characteristics. In this work, the principles of "harmonic" structure fabrication allowing to control both topology and scale of the bimodal structure heterogeneity have been concisely formulated. The feasibility to form
