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The Port of Rotterdam is an important industrial cluster mainly comprising of oil refining, chemical manufacturing and power and steam generation. In 2015, the area accounted for 18 % of the Netherlands' total CO2 emissions. The Port of Rotterdam Authority is aware that the port's economy is heavily exposed to future global and EU decarbonization policies, as the bulk of its activities focuses on
This is an overview paper that motivates and describes performed work done in the European Commission funded research project BASTION, which focuses on two critical problems of modern electronics: the No-Fault-Found (NFF) and CMOS ageing. New defect classes contributing to NFF have been identified, including timing related faults (TRF) at board level and intermittent resistive faults (IRF) at IC l
Glucagon levels are classically suppressed after glucose challenge. It is still not clear as to whether a lack of suppression contributes to hyperglycemia and thus to the development of diabetes. We investigated the association of postchallenge change in glucagon during oral glucose tolerance tests (OGTTs), hypothesizing that higher postchallenge glucagon levels are observed in subjects with impai
Recombinant antibody libraries can provide a source of renewable and high-performing binders tailored for use in affinity proteomics. In this context, the process of generating site-specific 1:1 tagging/functionalization and/or orientated surface immobilization of antibodies has, however, proved to be challenging. Hence, novel ways of generating such engineered antibodies for use in affinity prote
Background. Search and selection of primary studies in Systematic Literature Reviews (SLR) is labour intensive, and hard to replicate and update. Aims. We explore a machine learning approach to support semi-automated search and selection in SLRs to address these weaknesses. Method. We 1) train a classi er on an initial set of papers, 2) extend this set of papers by automated search and snowballing
Owing to its diagenetic instability, aragonite is rare in the geological record and almost entirely absent from pre-carboniferous sedimentary rocks. The former presence of this mineral in older deposits has to be inferred from petrographic, chemical or isotopic proxies. Crystals of aragonite that formed around 4563 million years ago occur in carbonaceous chondrite meteorites, showing that under ce
Parkinson's disease (PD) is a common, progressive neurodegenerative disorder associated with a loss of dopaminergic cells in the substantia nigra pars compacta and a lack of dopamine in the striatum. To halt or reverse this disease, neurorestorative approaches or neuroprotective treatments are urgently needed. Recently, the first clinical trials transplanting mesenchymal stem cells (MSCs) have bee
This article discusses the role of the protein corona in delivery systems with tagged nanoparticles and how knowledge of the protein corona can help in optimizing delivery. The basic question is whether and how the binding of proteins and other biomolecules at the nanoparticle surface interfere with the interaction between a tag and its receptor. This is an interesting problem in many respects, bu
BACKGROUND: Clinical outcome of patients with triple-negative breast cancer (TNBC) is highly variable. This study aims to identify and validate a prognostic protein signature for TNBC patients to reduce unnecessary adjuvant systemic therapy.METHODS: Frozen primary tumors were collected from 126 lymph node-negative and adjuvant therapy-naive TNBC patients. These samples were used for global proteom
Reduced pancreatic b-cell function or mass is the critical problem in developing diabetes. Insulin release from b-cells depends on Ca2+ influx through high voltage- gated Ca2+ channels (HVCCs). Ca2+ influx also regulates insulin synthesis and insulin granule priming and contributes to β-cell electrical activity. The HVCCs aremultisubunit protein complexes composed of a pore-forming a1 and auxiliar
Mechanical behavior of the shear connections has a significant influence on both the load-carrying capacity and the bending stiffness of timber-concrete composite (TCC) beams. All the studies reported so far have concentrated on the performance of TCC connections in mature concrete. The performance of shear connections for TCC beams at early concrete ages, however, has not been investigated yet. T
AIMS: While workplace wellness services are proactively established to improve well-being and reduce sickness absence, knowledge of reasons for using these services remains sparse. This study investigates which factors determine use of an in-house wellness service at a large organization (the Danish Police) with several departments in different geographical locations.METHODS: All potential users o
Source location for real aperture radar (RAR) has raised many concerns in the fields of ground-based monitoring for aircrafts and vessels. Notably, the resolution of RAR in azimuth is constrained by the antenna beam width, which results in low degree of location accuracy. In this paper, we exploit the inherent sparseness of the target distributions to formulate a superresolution methodology to loc
This paper examines information services in association with charging services, and in particular players that offer information services related to charging service offerings from many different operators. It identifies two main types of business models through studying and comparing 25 European charging information service providers. For one type of players the paper analyses the network charact
Objectives: To analyse and present regression models that can describe the long-term change in cognitive function (MMSE and ADAS-cog) of patients treated with donepezil for three years (n=435). Methods: The Swedish Alzheimer Treatment Study (SATS) is an open, 3-year, multicentre study in a routine clinical setting. Patients with the diagnosis of Alzheimer’s Diseases received the cholinesterase inh
The diagnosis of Alzheimer's disease can be improved by the use of biological measures. Biomarkers of functional impairment, neuronal loss, and protein deposition that can be assessed by neuroimaging (ie, MRI and PET) or CSF analysis are increasingly being used to diagnose Alzheimer's disease in research studies and specialist clinical settings. However, the validation of the clinical usefulness o
Motivated by experimental findings on one-dimensional nano-materials, this contribution focusses on the elaboration of a fibre curvature based higher-order gradient contribution to the stored energy function in a finite deformation setting. The presented approach is based on the fundamental theoretical developments for fibre-reinforced composites presented by Spencer and Soldatos (2007), which tak
