Sökresultat

Smart contracts are programs with data (mutable state); stored on and executed by blockchain platforms. The transactions (or function invocations) dispatched to smart contracts often change their state. In the Ethereum blockchain, nodes (aka miners/validators) can schedule a set of transactions in any order in a block. Multiple transactions in a single block operating on a contract's shared state

Background: We aim to estimate population-attributable fractions (PAF) for 13 comorbidities potentially predisposing to hepatobiliary cancer of hepatocellular carcinoma (HCC), gallbladder cancer (GBC), cancers of the intrahepatic and extrahepatic bile ducts (ICC and ECC), and ampullary cancer. Methods: Patients were identified from the Swedish Inpatient Register from 1987 to 2018 and cancers from

The significance of neutron spin adiabaticity in the data analysis of polarized Grazing Incidence Small Angle Neutron Scattering (GISANS) is discussed, with the aim of minimizing the number of simulation parameters of complex magnetic models within the neutron scattering cross-section. We illustrate how an estimate of the neutron polarization direction and adiabaticity can be obtained by magnetic

Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and ter

Herein, we present KiMoPack, an analysis tool for the kinetic modeling of transient spectroscopic data. KiMoPack enables a state-of-the-art analysis routine including data preprocessing and standard fitting (global analysis), as well as fitting of complex (target) kinetic models, interactive viewing of (fit) results, and multiexperiment analysis via user accessible functions and a graphical user i

People appear to vary in their susceptibility to lifestyle risk factors for cardiometabolic disease; determining a priori who is most sensitive may help optimize the timing, design, and delivery of preventative interventions. We aimed to ascertain a person's degree of resilience or sensitivity to adverse lifestyle exposures and determine whether these classifications help predict cardiometabolic d

We present a compact, few-cycle, short-wave infrared light source delivering 13 μJ, carrier-envelope phase (CEP) stable pulses around 2 μm, operating at 200 kHz repetition rate. Starting from an ytterbium fiber amplifier, the seed is produced via white-light generation followed by difference frequency generation, and later amplified in two BiBO nonlinear crystals. A pulse duration of 15.8 fs is me

Biological scaffold is a popular choice for the preparation of tissue-engineered organs and has the potential to address donor shortages in clinics. However, biological scaffolds prepared by physical or chemical agents cause damage to the extracellular matrix (ECM) by potentially inducing immune responses after implantation. The current study explores the fate of the decellularized (DC) scaffolds

Multiple myeloma (MM) is a blood malignancy originating from plasma cells. First-degree relatives of patients with MM have two- to four-fold higher risk of MM. However, the molecular basis remains largely unknown. This Ph.D. project aims to identify novel DNA sequence variants predisposing to MM through genome-wide association studies (GWAS) and, subsequently, characterize identified variants func

Therapeutic antibodies are transforming the treatment of cancer and autoimmune diseases. Today, a key challenge is finding antibodies against new targets. Phenotypic discovery promises to achieve this by enabling discovery of antibodies with therapeutic potential without specifying the molecular target a priori. Yet, deconvoluting the targets of phenotypically discovered antibodies remains a bottl

Hydrogenated graphene (H-Gr) is an extensively studied system not only because of its capabilities as a simplified model system for hydrocarbon chemistry but also because hydrogenation is a compelling method for Gr functionalization. However, knowledge of how H-Gr interacts with molecules at higher pressures and ambient conditions is lacking. Here we present experimental and theoretical evidence t

We report a spatially resolved spectroscopic study of the visible chemiluminescence emission from different premixed ammonia-air-oxygen flames stabilized on a laminar flat flame burner, with equivalence ratio ranging from 0.7 to 1.35 and an O2/N2 ratio of 0.4. In the reaction zone of the observed flames, the visible emission was recognized to be the chemiluminescence of excited NH2* radicals, whil

This thesis work concerns studies of two rare-earth-ions, praseodymium (Pr3+) and europium (Eu3+), doped into a yttrium orthosilicate (Y2SiO5) crystal for applications in quantum computing. The nuclear spin levels of these ions can have very long coherence times, up to several hours. Coherence can also be effectively transferred between the optical and hyperfine levels. These systems, therefore, h

Background. Persistent intolerable pain is still an unsolved issue with a huge socioeconomic impact. To develop appropriate treatments, it is crucial to understand the complex mechanisms underlying pain and how they change during sustained pain stimuli or during pathological conditions. In particular, it is essential to clarify how the endogenous analgesic centres which are present in the brain, s

Cells adhering onto surfaces sense and respond to chemical and physical surface features. The control over cell adhesion behavior influences cell migration, proliferation, and differentiation, which are important considerations in biomaterial design for cell culture, tissue engineering, and regenerative medicine. Here, we report on a supramolecular-based approach to prepare reversible self-assembl

Many animal behaviors require orientation and steering with respect to the environment. For insects, a key brain area involved in spatial orientation and navigation is the central complex. Activity in this neural circuit has been shown to track the insect’s current heading relative to its environment and has also been proposed to be the substrate of path inte-gration. However, it remains unclear h

Diabetes is characterized by hyperglycaemia and entails many complications, including retinopathy and entrapment neuropathies, such as ulnar nerve entrapment (UNE) and carpal tunnel syndrome (CTS). Hyperglycaemia damages the nerves of the retina, as well as peripheral nerves. There is a correlation between entrapment neuropathies and retinopathy in patients with diabetes, but whether patients with