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Background: Evidence-based guidelines for assessing pituitary function in children remain limited. Improved understanding of paediatric pituitary diseases may improve clinical management and patient counselling.Aim: This thesis aimed to evaluate diagnostic aspects of paediatric pituitary diseases, focusing on radiological follow-up of pituitary microadenomas and cysts, pituitary refractoriness to
Tolkning av entreprenadavtal – konst eller teknik? 2020-11-11, 16:30 - 18.30 Online (Zoom) HD har i flera avgöranden under 2010-talet redogjort för hur tolkning av AB 04 och ABT 06 bör gå till. I boken ”Tolkning av entreprenadavtal” (Norstedts Juridik 2020) har Anders Ingvarson och Marcus Utterström undersökt vilket genomslag HD:s praxis fått i underrätterna och om HD:s ”tolkningsmetod” även till
https://www.aclu.lu.se/evenemang/genomforda-evenemang/2020 - 2026-07-23
Knowledge about subjects who sustain hip fractures in middle age is poor. This study prospectively investigated risk factors for hip fracture in middle age and compared risk factors for cervical and trochanteric hip fractures. The Malmo Preventive Project consists of 22,444 men, mean age 44 years, and 10,902 women, mean age 50 years at inclusion. Baseline assessment included multiple examinations
Background: Women are less likely to receive oral anticoagulation or ablation for treatment of atrial fibrillation (AF). Identification of sex differences in arrhythmia characteristics and symptoms may lead to a better understanding of potential reasons for these differences. Objectives: To determine sex differences in AF with respect to heart rate, duration, burden, and symptoms in patients under
OBJECTIVES: Digital breast tomosynthesis (DBT) can detect more cancers than the current standard breast screening method, digital mammography (DM); however, it can substantially increase the reading workload and thus hinder implementation in screening. Artificial intelligence (AI) might be a solution. The aim of this study was to retrospectively test different ways of using AI in a screening workf
Background: Associations between air pollution and chronic kidney disease (CKD) have been reported, but studies at low exposure levels and relevant exposure time windows are still warranted. This study investigated clinical CKD at low air pollution levels in the Swedish Malmö Diet and Cancer Cohort in different exposure time windows. Methods: This study included 30,396 individuals, aged 45–74 at e
BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) are persistent substances with surfactant and repellent properties. Municipal drinking water contaminated with PFAS had been distributed for decades to one third of households in Ronneby, Sweden. The source was firefighting foam used in a nearby airfield since the mid-1980s. Clean water was provided from December 16, 2013.AIMS: The purpose was
PURPOSE: The frequency of activated protein C (APC) resistance, caused by factor V R506Q gene mutation and abnormal APC ratio, in patients with peripheral vascular diseases was analyzed. METHODS: All patients electively admitted to the vascular ward unit of our tertiary care academic medical center from January 1995 through October 1996 (n = 679) were prospectively analyzed using an APC-resistance
Subjects with impaired glucose tolerance (IGT) are usually overweight and exhibit insulin resistance with a defective compensation of insulin secretion. In this study, we sought to establish the interrelation between insulin secretion and insulin sensitivity after oral glucose in non-obese subjects with IGT and we also examined this interrelation in relation to the 2 main incretins, glucagon-like
This thesis concerns involuntary treatment of alcoholism. Clients committed according to the Swedish Act on Care of Addicts in Certain Cases were treated in the same residential treatment setting as voluntarily admitted clients. After informed consent, 104 clients (73 men and 21 women of whom 56 were compulsorily committed and 47 voluntarily admitted) participated in a test-series, including asses
This thesis concerns a novel alkaline protease produced by an extremophilic microbial specie, designated as AL20, isolated from a feather sample collected at the shore of the alkaline soda lake Abjata in the Ethiopian Rift Valley. The isolate is a heterotrophic, alkaliphilic, halotolerant gram-positive, strictly aerobic, non-motile, non-spore forming bacterium. The organism grew at 37°C, pH 10, an
Popular Abstract in Swedish Många åtminstone i min generation kommer säkert ihåg att de under gymnasiets biologilektioner fick lära sig att vatten diffunderade fritt över cellens membran ? osmos och fri diffusion var ledorden. Jag vet inte hur läroböckerna är utformade idag, men efter att Nobelpriset i kemi år 2003 tilldelades Peter Agre för upptäckten av att aquaporiner fungerar som vattenkanalerIn order to identify integral and peripheral proteins associated with the plasma membrane (PM), highly purified Arabidopsis PMs were analyzed by mass spectrometry. In total, 238 putative PM proteins were identified, of which 114 were predicted to have transmembrane domains or to be PM-anchored. Identified proteins were involved in transport, signal transduction, membrane trafficking and stress res
Popular Abstract in Swedish Att opereras via titthålskirurgi eller öppen kirurgi med en operationsteknik som förhindrar sura uppstötningar och halsbränna - en slumpmässig jämförande studie från ett patientperspektiv Utdrag ur avhandlingen Laparoscopic or open surgery - A comparative study with special reference to the patient's perspective av Gunilla Nilsson Vad är problemet? Gastroesofageal reThe overall aim of this thesis was to compare the effects of laparoscopic versus open antireflux surgery in a randomized clinical trial focusing the patients' subjective and objective outcome postoperatively, from a short-term and a long-term perspective. A further aim was to describe GORD patients' experiences of illness and surgical treatment and if possible to find striking characteristics rela
Background High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease processes, mendelian randomisation can be used to test the hypothesis that the association of a plasma biomar
The current epidemiologic evidence suggests that men with type 2 diabetes mellitus may be at lower risk of developing prostate cancer, but little is known about its association with stage and grade of the disease. The association between self-reported diabetes mellitus at recruitment and risk of prostate cancer was examined in the European Prospective Investigation into Cancer and Nutrition (EPIC)
Northern peatlands, spanning across vast regions of the northern hemisphere, are critical carbon reservoirs essential for global carbon cycling and climate regulation. Their dual role as long-term atmospheric carbon dioxide (CO2) sinks and the largest natural source of methane (CH4) in the northern hemisphere allows them to accumulate more carbon than they emit, helping to mitigate the rise in atm
Apolipoprotein A-I (ApoA-I) is the most predominant protein of high-density lipoprotein (HDL), which is an essential component for reverse cholesterol transport (RCT). ApoA-I has many health-promoting functions, such as anti-atherosclerosis and antioxidant properties; however, carriers of certain rare mutations in the APOA1 gene suffer from a disease called hereditary ApoA-I-related amyloidosis. A
Introduction Attrition from antiretroviral therapy (ART) programmes is a critical challenge among children receiving care in resource-limited settings. Our objective was to determine the rates and predictors of attrition among children on ART in Ethiopia. Methods Between December 2014 and September 2016, we conducted a prospective cohort study in eight health facilities in Ethiopia. Eligibility cr
OBJECTIVE: To evaluate a system for delivery of inhaled nitric oxide.DESIGN: Prospective, laboratory study.SETTING: Engineering laboratory.SUBJECTS: A standard ventilator (Servo Ventilator 300), supplemented with extra gas modules for nitric oxide delivery.INTERVENTIONS: Two ventilator-integrated gas modules, delivering < or = 10 parts per million (ppm) or < or = 100 ppm of nitric oxide, were used
Background: Falciparum malaria is an important risk factor for African Burkitt lymphoma (BL), but few studies have evaluated malaria patterns in healthy BL-age children in populations where both diseases are endemic. To obtain accurate current data, patterns of asymptomatic malaria were investigated in northern Uganda, where BL is endemic. Methods: Between 2011 and 2015, 1150 apparently healthy ch
