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BACKGROUND: Oxaliplatin and Mitomycin C (MMC) are both suitable as intraperitoneal chemotherapy agents in HIPEC for peritoneal carcinomatosis (PC) of colorectal cancer (CRC).METHODS: Patient cohorts from two different HIPEC-centers underwent cytoreductive surgery and HIPEC with Oxaliplatin (39 patients) and MMC (56 patients), respectively. They were compared for toxicity and survival data. The ext
Background: The pathological response to preoperative chemotherapy of colorectal liver metastases (CRLMs) is predictive of long-term prognosis after liver resection. Accurate preoperative assessment of chemotherapy response could enable treatment optimization. Purpose: To investigate whether changes in lesion-apparent diffusion coefficient (ADC) measured with diffusion-weighted magnetic resonance
Background: Randomised controlled trials in surgery can be a challenge to design and conduct, especially when including a non-surgical comparison. As few as half of initiated surgical trials reach their recruitment target, and failure to recruit is cited as the most frequent reason for premature closure of surgical RCTs. The aim of this qualitative evidence synthesis was to identify and synthesise
Background and purpose — Obesity has been associated with inferior outcomes after laminectomy due to central lumbar spinal stenosis (CLSS); we evaluated whether this occurs in surgery on national bases. Patients and methods — We retrieved pre-and 1-year postoperative data from the National Swedish Quality Registry for Spine Surgery regarding patients aged ≥ 50 with laminectomy due to CLSS in 2005–
The emergence of a monkeypox (MPOX) outbreak in 2022 represented the most recent recognizable public health emergency at a global level. Improving knowledge and attitude towards MPOX, particularly among healthcare workers (HCWs), can be a valuable approach in public health preventive efforts aiming to halt MPOX virus spread. The aim of the current study was to evaluate the knowledge and attitude o
Proteins are tiny chemical machines that play many critical roles in our body. Some proteins send important messages, some carry crucial supplies, some fight with invaders and protect body from diseases, some clear trash etc. Proteins are strings of hundreds and thousands of small units called amino acids. If the string is built from less than hundred amino acids, it is called a peptide. DNA, a loThe pathogenesis of Alzheimer’s disease is widely believed to be due to production and deposition of the amyloid β-peptide. Several variants of the Aβ peptide are known to exist in in vivo. Variations include mutations or additional functional groups attached to residue side chains and may affect the aggregation process. Early on-set Alzheimer’s is caused by a variety of single amino acid substitu
The overarching objective of this study was to produce a disaggregated SMOS Soil Moisture (SM) product using land surface parameters from a geostationary satellite in a region covering a diverse range of ecosystem types. SEVIRI data at 15 min temporal resolution were used to derive the Temperature and Vegetation Dryness Index (TVDI) that served as SM proxy within the disaggregation process. West A
Background: Optimal infusion rate of colloids in patients with suspected hypovolemia is unknown, and the primary objective of the present study was to test if plasma volume expansion by 5% albumin is greater if fluid is administered slowly rather than rapidly. Methods: Patients with signs of hypoperfusion after major abdominal surgery were randomized to intravenous infusion of 5% albumin at a dose
The present study focuses on NNE-trending dykes (sites LDA to LDJ) that occur near Mashishing in the eastern Kaapvaal craton. The Mashishing dykes were previously considered to be coeval and regarded as the extension of the 1.875–1.835Â Ga Black Hills dyke swarm into the sedimentary rocks of the Pretoria Group. Thin sections exhibit well-preserved igneous textures, with primary minerals (e.g., hor
PURPOSE: multiple myeloma is considered an incurable hematologic cancer but a subset of patients can achieve long-term remissions and survival. The present study examines the clinical features of long-term survival as it correlates to depth of disease response. PATIENTS & METHODS: this was a multi-institutional, international, retrospective analysis of high-dose melphalan-autologous stem cell
Oil palm plantation expansion is occurring at a rapid pace. However, substantial yield losses from pest attacks are becoming major threats to the oil palm industry, while the potential role of conservation biological control, a sustainable and environmentally friendly solution for pest control, is still largely unknown. The type of vegetation surrounding oil palm plantations is likely to influence
This study evaluates the impact of agricultural subsidies (CAP) on employment outside the agricultural sector. A side-effect of the decoupling reform in 2005 was that Sweden introduced a grassland support which caused a redistribution of payments among regions. This heterogeneity in transfers is used to identify the effects of government transfers on regional labour markets. The effect on employme
BACKGROUND: Approximately 570 patients are diagnosed with multiple myeloma (MM) in Sweden each year. Few studies have estimated the cost of treatment for these patients. OBJECTIVE: The purpose of this study was to retrospectively investigate the direct hospital resource utilization and costs associated with the treatment of patients with MM in southwest Sweden. METHODS: Patients aged > or =18 year
OBJECTIVE: This nationwide study aimed to determine whether venous thromboembolism (VTE) shares familial susceptibility with aortic aneurysm (AA), peripheral artery disease (PAD) and arterial thrombosis and embolisation (ATE) in locations other than the heart and brain.METHODS: Nationwide Swedish family study. Data from the Swedish Multi-Generation Register for subjects aged 0-78 years old, coveri
Föreliggande uppsats har baserats på ett empiriskt utvärderingsmaterial (enkät), där syftet är att beskriva och analysera uppskattningsvis 1 700 studerandes upplevelser av Kunskapslyftet i Landskrona över en fyraårs period, år 1998-2001. Utgångspunkten var min erfarenhetsbaserade kunskap av de studerande på Kunskapslyftet i Landskrona där jag varit projektsamordnare. Med stöd av två teoretiska per
PURPOSE The ESPAC4 trial showed that adjuvant chemotherapy with gemcitabine plus capecitabine (GemCap) produced longer overall survival (OS) than gemcitabine monotherapy. Subsequently, the PRODIGE24-CCTG PA.6 trial showed even longer survival for modified fluorouracil, folinic acid, irinotecan, and oxaliplatin (mFOLFIRINOX) than gemcitabine but had more restrictive eligibility criteria. Our aim wa
BACKGROUND: Trace elements like iodine have been suggested to be associated with breast cancer due to their antioxidant properties and ecological differences in incidence and mortality. Yet, there are no epidemiological studies on breast cancer prognosis in relation to iodine levels. The primary aim of this study was to investigate the association between prediagnostic serum iodine levels and brea
