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Introduction. Rho kinases (ROKs) cause calcium-independent modulation of smooth muscle contraction. A significant role for the RhoA/ROK pathway in mediating the contraction of the penile erectile tissue has been suggested. Moreover, it has been postulated that ROK activity might represent a key factor in the pathophysiology of erectile dysfunction. Up until today, little is known on the significan
Abstract Purpose: To describe the most prominent use of or perceived unmet need of assistive technology (AT) and to compare the characteristics of users, non-users and those expressing perceived unmet need with respect to overall health, independence in everyday life, environmental barriers and socio-demographic features. Method: The study is based on data collected in the "Home and Health in the
Dödsstraffet är ett straff som har diskuterats i hundratals år. Jag är själv fascinerad av de argument som har använts, och fortfarande används, för och emot bibehållandet av strafftypen. Genom att studera förarbeten och doktrin har jag försökt utreda hur och varför Sverige avskaffade dödsstraffet. Jag har också jämfört den svenska processen med den som pågick vid ungefär samma tid i Danmark. BådaThe death penalty has been debated for hundreds of years. I am personally fascinated by the arguments used for keeping and removing the penalty from the legislation. I have by studying the legislative history and doctrine tried to research how and why Sweden abolished the death penalty. I also compared the results with the same process in Denmark. Both countries chose to abolish the death penalty
Den här uppsatsen kretsar kring svenska kommuners drift av gym, en företeelse som gör att kommunen agerar som aktör på den öppna marknaden. I takt med att allt mer av den offentliga och den privata sektorn har smält samman så har också antalet konkurrenskonflikter som detta kan föranleda ökat. Det privata näringslivet har under årtionden påtalat att de upplever det som ett problem och att den offeThis essay revolves around Swedish municipalities' operation of gyms, a phenomenon that makes the municipalities act as players on the open market. As more and more of the public and private sectors have merged the number of competitive conflicts that this has caused has also increased. The private sector has, for decades, complained that it feels it is an issue and that the public sector is n
Cardiac magnetic resonance (CMR) images are used to investigate the heart for medical and research purposes. By injecting a contrast substance into the patient, myocardial infarctions (heart attacks) can be visualized in CMR image sets consisting of a number of image slices at different levels of the heart. Analysis of these images can detect an infarction, delineate it and estimate its size. This
I Sverige drabbas omkring 300 barn av cancer varje år och majoriteten av dem är bara fyra-fem år gamla när de får sin diagnos. Omkring två tredjedelar av barncancerdiagnoserna utgörs av leukemier, lymfom och hjärntumörer, medan den sista tredjedelen är olika solida tumörformer som njurtumörer och nervvävnadstumörer i buken. Cancersjukvårdens utveckling under de senaste årtiondena har medfört en avPurpose: The purpose of this study was to evaluate the impact of including PET (Positron Emission Tomography) in the process of pediatric radiation therapy planning. The aim was to study the effect on target volumes and how this in turn affects the resulting treatment plans. This study also aims to compare the estimated risks of various long-term complications and how the use of PET influences the
There is an ongoing discussion in information retrieval research regarding the merits of subject indexing with controlled vocabularies as opposed to relying on free-text descriptions. Earlier research has compared subject headings with other metadata, such as document titles or tables of contents, to determine the relative value of subject headings as subject access points in an information search
Stellar abundances are important for understanding the chemical evolution of galaxies and provide us with constraints on stellar evolution and supernova nucleosynthesis. To determine stellar abundances accurately, atomic data is crucial. This data is incomplete for many elements, especially in the infrared region. In particular, hyperfine structure (hfs) data in the near-infrared region is lacking
BIM, byggnadsinformationsmodellering, är ett arbetssätt som blir allt vanligare. Det innebär att olika objekt bygger upp en övergripande 3D-modell där man kan finna mängder av information om dessa objekt. Ett objekt kan vara allt ifrån en bropelare till en elstolpe. Syftet med denna rapport är att utifrån Trafikverkets roll som beställare undersöka vilka för- och nackdelar det skulle innebära med BIM, Building Information Modeling, is an increasingly common way of working. This means that different objects build up an overall 3D-model where you can find lots of information about these objects. An object can be anything from a bridge pillar to an electric pole. The purpose of this report is to, based on the Swedish Transport Administrations’ as a client, investigate the advantages and disad
Introduction: This study attempts to optimize the choice of stationary phase for the separation of lignosulfonate lignin compounds using supercritical fluid chromatography coupled to mass spectrometry. Background: Lignin is a potential renewable source of phenolic compounds. Lignosulfonate lignins are produced during pulping processes producing very complex mixtures, which are challenging to anal
Popular Abstract in English Neuroplasticity is the brain´s capacity to respond to inner and outer challenges with functional and structural reorganizations. An aberrant activation of neuroplasticity pathways may contribute to the development of neurological disease. In the case of Parkinson’s disease (PD), the induction of motor complications by L-DOPA pharmacotherapy is generally regarded as an eNeuroplasticity is the brain´s capacity to respond to inner and outer challenges with functional and structural reorganizations. An aberrant activation of neuroplasticity pathways may contribute to the development of neurological disease. In the case of Parkinson’s disease (PD), the induction of motor complications by L-DOPA pharmacotherapy is generally regarded as an example of maladaptive plasti
Cationic liposome-DNA (CL-DNA) complexes, are regarded as promising materials for safe and efficient delivery of genes for therapeutical applications. In order to be used in vivo, these complexes may be coated with a hydrophilic polymer (e.g. polyethylene-glycol, PEG) that provides steric stabilization towards adhesion of proteins and removal by the immune system. In this work we study the influen
Popular Abstract in Swedish Inom forskningsområdet biogeokemi studerar man hur naturens olika grundämnen, såsom kol, kväve, fosfor och kisel ändrar form och transporteras genom landskapet för att via bäckar och vattendrag till slut nå havet. Tillsammans beskriver dessa olika processer, som sker på olika tidsskalor, från sekunder till flera miljoner år, ett grundämnes kretslopp (eller biogeokemiskaSilicon is the next most abundant element in the Earth’s crust and its biogeochemical cycle is linked with that of carbon. Further, silicon is a beneficial nutrient for plants in terrestrial ecosystems and a key nutrient for diatoms in aquatic ecosystems. During the last decade the important role of terrestrial vegetation in controlling Si fluxes downstream aquatic environments, via incorporation
We present an extensive rheology study of the wormlike micelle system lecithin-water-cyclohexane. In this system the micelles are really wormlike, meaning that there are no signs of micellar branching, as it has previously been demonstrated by NMR self-diffusion experiments (R. Angelico, U. Olsson, G. Palazzo and A. Ceglie, Phys. Rev. Lett., 1998, 81, 2823). Wormlike micelles break and recombine,
Background: Research involving expressed sequence tags ( ESTs) is intricately coupled to the existence of large, well-annotated sequence repositories. Comparatively complete and satisfactory annotated public sequence libraries are, however, available only for a limited range of organisms, rendering the absence of sequences and gene structure information a tangible problem for those working with ta
Popular Abstract in Swedish Kroppens immunförsvar, vars uppgift är att skydda oss mot infektioner, består av ett antal olika celltyper som till stor del finns i blodet. Immunförsvaret kan indelas i två delar; ett medfött försvar som är likadant hos alla individer och ett försvar som byggs upp under individens livstid. Det senare utformas olika beroende på vilka bakterier och virus som individen utThe cells of the innate immune system are essential for the host's first line defence against infection. Among these cells the neutrophil granulocyte has a central role by the production of antibiotic proteins and peptides. These are targeted for storage in secretory lysosomes and other neutrophil granules for subsequent release by regulated secretion in an inflammatory process. However, the granu
In a warming climate, permafrost is likely to be significantly reduced and eventually disappear from the sub-Arctic region. This will affect people at a range of scales, from locally by slumping of buildings and roads to globally as melting of permafrost will most likely increase the emissions of the powerful greenhouse gas methane, which will further enhance global warming. In order to predict fu
The objective of this thesis is to propose a way to introduce social and cultural aspects of environmental degradation to the sustainable development debate. This is done by a reflexive and critical examination of environmental research as it has been applied to different spatial levels (and thus levels of social complexity). The spatial categories discussed are the city, the household and the lan
Diamonds are regarded to be one of the most valuable natural resources on earth, with an average rough diamond price of $71 per carat in 2000. This gives scope for great economic success in diamond abundant countries. Some of the worlds most diamond abundant countries are found in Africa, ironically also some of the poorest. In recent years it has been brought to the world’s attention that illicit
