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Background: Quantitative magnetic resonance imaging (MRI), e.g. relaxation parameter mapping, may be sensitive to structural and compositional tissue changes, and could potentially be used to non-invasively detect and monitor early meniscus degeneration related to knee osteoarthritis. Objective: To investigate MR relaxation times as potential biomarkers for meniscus degeneration through comparison
ABSTRACT: Neuroinflammation is implicated in the development and maintenance of persistent pain states, but there are limited data linking cerebrospinal fluid (CSF) inflammatory mediators with neurophysiological pain processes in humans. In a prospective observational study, CSF inflammatory mediators were compared between patients with osteoarthritis (OA) who were undergoing total hip arthroplast
Purpose: The quantitative accuracy of Nuclear Medicine images, acquired for both planar and SPECT studies, is influenced by the isotope-collimator combination as well as image corrections incorporated in the iterative reconstruction process. These factors can be investigated and optimised using Monte Carlo simulations. This study aimed to evaluate SPECT quantification accuracy for 123I with both t
Background: Weused a sensitive and specific beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) assay to determine the relationship between BACE1 activity in cerebrospinal fluid (CSF) and markers of APP metabolism and axonal degeneration in early and late stages of Alzheimer disease (AD). Objective: To assess CSF BACE1 activity in AD. Design: Case-control and longitudinal follow-up
The spawning behaviour of wild caught brood stock as well as early egg and larval development were studied in yellowtail kingfish (Seriola lalandi). Spawning occurred naturally in the austral spring/summer (November–February) when the seawater temperature was above 17 °C. Courtship behaviour involved one male and female, and consisted of a high-speed pursuit punctuated by stalling, nipping and tou
Popular Abstract in English Fruits are a key complement to the diet of many people in the southern region of Africa, especially in rural areas. maphilwa (Vangueria infausta L.), maçanica (Ziziphus mauritiana), maçala (Strychnos spinosa), mapsincha (Salacia kraussi), cajú (Anacardium accidentale L.), mavungwa (Landolpia kirki) are some of the most commonly found fruits in sub-Saharan Africa, particThis study concerns the identification and characterisation of volatile components of fruits, and evaluation of the effect of heat treatment and drying on retention or loss of volatiles of fruits. The investigation included developing a procedure to extract volatile components from the fruit matrix, a purification step, separation, identification and quantification. Initial experiments with Vangue
Background: In 2014 the Swedish government assigned to The Public Health Agency of Sweden to conduct studies to evaluate optimal use of existing antibiotic agents. The aim is to optimize drug use and dosing regimens to improve the clinical efficacy. The present study was selected following a structured prioritizing process by independent experts. Methods: This phase IV study is a randomized, open-
This study deals with the desalination plant at the Eastern Mediterranean University (Cyprus) and its environmental impact. The reverse osmosis plant produces normally 42m3/hr potable water from 120m3/hr feed. The feed concentration reaches up to 36,000ppm TDS, while an approximate amount of 73.8m3/hr is led out from a pipe of 10inches diameter with a concentration of about 56,000ppm and the perme
The accurate interpretation of Si isotope signatures in natural systems requires knowledge of the equilibrium isotope fractionation between Si-bearing solids and the dominant Si-bearing aqueous species. Aqueous silicon speciation is dominated by silicic acid (H4SiO4 o) in most natural aqueous fluids at pH < 8.5, but forms H3SiO4 −, H2SiO4 2−, and polymeric Si species in more alkaline fluids. In th
The workshop will focus on what first-year students to higher education needs to be successful and how a peer learning programme might address those needs. (~5 min for introduction)The workshop will start with a brainstorm session where participants in small groups will share thoughts and ideas on the question (~20 min for activity): “What would you like to affect with your new students? Provide s
BACKGROUND: Rehabilitation pathways are crucial to reduce stroke-related disability. Motivational Interviewing (MI), as a person-centered complex intervention, aimed to empower and motivate, and could be a resource to improve rehabilitation outcomes for older stroke survivors. The IMAGINE project aims to assess the impact of MI, as a complement to standard geriatric rehabilitation, on functional i
The need for more functionality and higher performance has increased the number of transistors to billions in current processors. A high number of transistors on the same chip area increases the power density, which in turn heats up the devices and lowers the life time of batteries. The increasing demand for devices relying on battery and harvested energies in the Internet of Things (IoT) era has
Background: Many pathological processes can disrupt the integrity of the glomerular capillary wall and cause a massive leakage of protein, resulting in nephrotic syndrome (NS). Clinical parameters such as age, sex, renal function, presence of diabetes, and how NS is defined influence the spectrum of underlying diseases. In this study, we examine how these parameters interact.Methods: Age, sex, hem
BACKGROUND: Atraumatic localized convexity subarachnoid hemorrhage (cSAH) is an uncommon form of nonaneurysmal subarachnoid hemorrhage characterized by bleeding limited to the cerebral convexities. Ipsilateral cSAH can result from a variety of causes, such as internal carotid artery stenosis, obstruction, and dissection, although concomitant contralateral cSAH is exceptionally rare. In this case,
BACKGROUND AND OBJECTIVES: Several pathologic processes might contribute to the degeneration of the cholinergic system in aging. We aimed to determine the contribution of amyloid, tau, and cerebrovascular biomarkers toward the degeneration of cholinergic white matter (WM) projections in cognitively unimpaired individuals. METHODS: The contribution of amyloid and tau pathology was assessed through
Tau accumulation starts during the preclinical phase of Alzheimer's disease and is closely associated with cognitive decline. For preventive purposes, it is important to identify factors associated with tau accumulation and spread. Studying genetically identical twin-pairs may give insight into genetic and environmental contributions to tau pathology, as similarities in identical twin-pairs largel
Summary. This review describes the background for the development of recombinant FVIIa (rFVIIa; NovoSeven) for use in haemophilic patients with inhibitors. The first proof of principle for using pharmacological doses of FVIIa as a haemostatic agent was obtained by producing small amounts of pure plasma-derived FVIIa, which showed encouraging effect in two patients with haemophilia A and inhibitors
Quantum annealing has shown promise for finding solutions to difficult optimization problems, including protein folding. Recently, we used the D-Wave Advantage quantum annealer to explore the folding problem in a coarse-grained lattice model, the HP model, in which amino acids are classified into two broad groups: hydrophobic (H) and polar (P). Using a set of 22 HP sequences with up to 64 amino ac
Adherence to antiretroviral therapy is a global problem among adolescents living with human immunodeficiency viruses (HIV), and it is associated with treatment failure and the development of viral resistance. One of the most significant barriers to treatment adherence among adolescents is forgetting to take drugs as prescribed. One of the key strategies recommended to improve this problem is the u
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https://www.lth.se/english/research/research-infrastructures/ - 2026-07-09
