Filtyp
The key step in the reaction mechanism of multicopper oxidases (MCOs)-the cleavage of the O-O bond in O-2-has been investigated using combined quantum mechanical and molecular mechanical (QM/MM) methods. This process represents a reaction pathway from the peroxy intermediate after it accepts one electron from the nearby type-1 Cu site to the experimentally-observed native intermediate, which is th
Readouts that define the physiological distributions of drugs in tissues are an unmet challenge and at best imprecise, but are needed in order to understand both the pharmacokinetic and pharmacodynamic properties associated with efficacy. Here we demonstrate that it is feasible to follow the in vivo transport of unlabeled drugs within specific organ and tissue compartments on a platform that appli
High-energy proton- and deuteron-nucleus collisions provide an excellent tool for studying a wide array of physics effects, including modifications of parton distribution functions in nuclei, gluon saturation, and color neutralization and hadronization in a nuclear environment, among others. All of these effects are expected to have a significant dependence on the size of the nuclear target and th
Diagnosis and risk stratification of patients with acute coronary syndromes can be improved by adding information from the depolarization phase (QRS complex) to the conventionally used ST-T segment changes. In this study, ischemia-induced changes in the main three slopes of the QRS complex, upward (I-US) and downward (I-DS) slopes of the R wave as well as the upward (I-TS) slope of the terminal S
According to the waste hierarchy principle, which constitutes the basis of European waste legislation, waste prevention and re-use are considered – most of the times – better waste management options than recycling. However, prevention and re-use activities are difficult to operationalise and measure, without a monitoring framework in place. This contribution investigates the potential of re-using
Purpose: To validate a new 2D-3D registration method of fusion imaging during aortic repair in a system prepared only for 3D-3D registration and to compare radiation doses and accuracy. Materials and Methods: The study involved 189 patients, including 94 patients (median age 70 years; 85 men) who underwent abdominal endovascular aneurysm repair (EVAR) with 2D-3D fusion on an Artis zee imaging syst
Hypothesis: Nitric oxide (NO)-releasing Pluronic F127 hydrogels (F127) containing dissolved S-nitrosothiols or pendant N-diazeniumdiolate (NONOate) groups have been described. The NO charging of these hydrogels is usually limited by their low stability or disruption of the micellar packing. S-nitrosothiol-terminated F127 may emerge as a new strategy for allowing NO delivery at different rates in b
In contrast to static objects, liquid structures such as drops, blobs, as well as waves and ripples on water surfaces are challenging to image in 3D due to two main reasons: First, the transient nature of those phenomena requires snapshot imaging that is fast enough to freeze the motion of the liquid. Second, the transparency of liquids and the specular reflections from their surfaces induce compl
Teachers’ experiences of school leadership behaviour and the social contexts in which these have taken place interest me. I aim to identify and understand what Swedish secondary school language teachers’ reflections are on what they require in terms of leadership from their principals in different contexts in order to gain personal job satisfaction. The objective is that this research can then fun
The purpose of this Bachelor thesis is to investigate and explain an ongoing process on the Swedish book- and publishing-market as a result of the new alternative ways of publishing. The investigation concerns questions about what need the electronic publishing fills for the authors compared to traditional publishing, and what happens to the writer’s role when published digitally on self-publishin
Participation of Civil Society Organisations (CSOs) has been greatly promoted by the European Union (EU) and many CSOs in social policy sphere in particular have increasingly gained their participatory venues and consultative status vis-a-vis EU institutions since the 90’s. However, their expected role to bring even the most marginalised groups’ voice into European policy making process poses a qu
Software Engineering activities are information intensive. Research proposes Information Retrieval (IR) techniques to support engineers in their daily tasks, such as establishing and maintaining traceability links, fault identification, and software maintenance. We describe an engineering task, test case selection, and illustrate our problem analysis and solution discovery process. The objective o
The molecular weight distribution and the viscosity of water-soluble polysaccharides isolated from carrots were investigated after different types of heat-treatment, commonly used when preparing food. The materials studied were blanched, boiled, microwaved and canned. Freezing, without any heat-treatment, was used as a reference process. The water soluble polysaccharides were isolated using two di
Digital volume correlation analysis of time-resolved X-ray microtomography scans acquired during in situ triaxial compression of Green River shale cores provided time series of 3-D incremental strain fields that elucidated evolving deformation processes by quantifying microscopic strain localization. With these data, we investigated the impact of mechanical anisotropy on microscopic strain localiz
Perovskite based photovoltaic devices are popularised by the rapid increase in their efficiencies. Understanding the fundamental physics and chemistry processes occurring upon excitation is key. We monitored the temporal evolution of the population and depopulation dynamics of various electronic states in FA0.85MA0.15PbI2.55Br0.45 by means of ultrafast transient absorption spectroscopy in the visi
Three different, state-of-the-art biogeochemical models are adapted in order to quantify the carbon dioxide (CO2), nitrous oxide (N 2O), and methane (CH4) exchanges between arable lands and the atmosphere. Biome-BGC and MOD17 are validated using the long-term measurement results from Hegyhátsál tall tower site (Western Hungary). After a simple bias correction, it was found that Biome-BGC is capabl
Monoamines are presumed to be diffuse metabotropic neuromodulators of the topographically and temporally precise ionotropic circuitry which dominates CNS functions. Their malfunction is strongly implicated in motor and cognitive disorders, but their function in behavioral and cognitive processing is scarcely understood. In this paper, the principles of such a monoaminergic function are conceptuali
Populärvetenskaplig sammanfattning: Geografiska informationssystem på internet är ett relativt nytt fenomen som främst har utvecklats från ett behov att distribuera geografisk data, dvs utbyte av digitala geografiska data och tillhörande tjänster. Men det är även ett kraftfullt verktyg för att presentera information på internet. Detta examensarbete i naturgeografi syftar till att skapa en webbaGIS on the Internet is a rather new phenomenon, which has evolved from the need of distributed geographical data. It is also a powerful tool for presenting information on the Internet. This master thesis aim to create a web based GIS application with information on lime spreading and the situation concerning acidification in the county of Kronoberg, Sweden. The web based GIS application will be us
