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Apicidin is a potent histone deacetylase inhibitor (HDACI) that selectively binds to histone deacetylases (HDACs) class I and interferes with the deacetylation process, which results in modification of acetylation level of cellular proteins. The aim of the study was to investigate the potential time and dose dependent cytotoxicity of the test compound, Apicidin, in pancreatic cancer cells Capan-1

Previous research suggests that time-based working memory limits of 2-3 s constrain the integration of verbal information, and that speakers tend to parse sentences into prosodic phrases that do not extend beyond this time window. The present study used Event-Related Potentials (ERPs) to investigate how time-driven implicit prosodic phrasing influences the syntactic processing of embedded clauses.

Sweden is part of a small European minority in the perceived societal gain of PPP. After a pilot PPP project in late 1990’s no additional project has been started in Sweden. Although there is interest from both public infrastructure clients and construction companies the national government has very clearly stated that infrastructure projects should be procured in a traditional way where all fundi

The HOO radical is a key intermediate in the atmosphere and is involved in a large number of reactions, including ozone loss cycles in the stratosphere and oxidation processes in the troposphere. This theses is a study of the HOO radical and its interactions with a number of small molecules that are present in the atmosphere. The HOO complexes were formed on the surface of growing argon matrices

Epistemic uncertainty has been suggested to be fundamental to human experience. The authors of this paper believe that people need to exercise creativity in their conjectures, drawing upon knowledge and experience, in order to generate solutions to both instrumental and epistemic problems, and encourage higher orders of learning. Innovative methodologies are needed which can provide support for in

Popular Abstract in Swedish Bostadsanpassning är en vanlig åtgärd inom kommunal service och rehabilitering. Avsikten är att ta bort fysiska miljöhinder i bostaden och den nära utemiljön för underlätta vardagliga aktiviteter och möjliggöra ett självständigt liv. Enligt svensk plan- och bygglagstiftning skall alla bostäder som byggs eller genomgår omfattande renoveringar vara tillgängliga och användHousing adaptation is a common intervention, in Sweden granted by municipal authorities, and performed in order to remove environmental barriers and enhance daily activities. In spite of increasing costs, efficient strategies for evaluation of the intervention are lacking. In this thesis, occupational therapy clients living in a south Swedish municipality and receiving housing adaptation grants we

Outcome questionnaires are increasingly being established as a validated mode of acquiring unbiased information on the results after health interventions. Using an assortment of questionnaires, distributed by mail to 27 372 and to a subgroup of 3 600 patients on file in the Swedish Knee Arthroplasty register (SKAR), relevant questionnaires were found to represent a feasable means of acquiring info

Examining the coverage in seven major Japanese and Taiwanese daily newspapers of a selection of events involving both societies in the first decade of the twenty-first century, this paper investigates the phenomenon of rhetorical instrumentalization of the past for present ideological purposes. The concerns of this study are the processes of dehistorization in Japanese and Taiwanese news and publi

Most studies of GABA(A) receptor accessory proteins have focused on trafficking, clustering and phosphorylation state of the channel-forming subunits and as a result a number of proteins and mechanisms have been identified that can influence the GABA(A) channel expression and function in the cell plasma membrane. In the light of a growing list of intracellular and transmembrane neuronal proteins s

Anaerobic digestion and the production of biogas can provide an efficient means of meeting energy needs locally and reducing organic loading due to untreated waste material in water recipients. Furthermore, residues after anaerobic digestion may be used as a fertilizer to improve the soil in many parts of the world. Most natural organic waste can be used in anaerobic digestion. In developing count

Ultrafast optical response and excitation energy dynamics in light harvesting pigment-protein complexes and in a few model systems have been studied both experimentally and theoretically. Femtosecond light pulses were employed to excite the system and monitor the subsequent time evolution of the transient absorption kinetics and anisotropy. A new form of pump-probe technique was developed for perf

Popular Abstract in Swedish Bildning, bearbetning och upplagring av cathepsin G, proteinas 3 och azurocidin - närbesläktade bakteriedödande proteiner i vita blodkroppar Människans kropp utsätts dagligen för fientliga attacker av olika sorters mikroorganismer, tillhörande bakterie-, virus- eller svampsläktet. Så länge vi är friska och vårt immunförsvar fungerar, kan vi som tur är framgångsrikt fö

Funded by European Community and Swiss government research project AZEP (Advanced Zero Emission Power Plant), the project was carried out at the Department of Energy Sciences at Lund Faculty of Engineering (LTH). The project addressed the development of a specific, zero emissions, gas turbine-based, power generation process to reduce local and global emissions in a cost-effective way. In this proj

E-procurement — e-business mechanisms deployed on procurement — offers many recent and innovative methods that can improve procurement in different ways. The key challenge of e-procurement, however, is how to apply the various e-procurement applications in such a way that they improve the procurement practice and sourcing strategy of a company. There is a demand for an investigation that scrutiniz

This paper explores the use of spreadsheets in budgeting in order to explain how and why spreadsheets are used or not used in budgeting practice. Guided by modern budgeting research, budgeting is considered as a social phenomenon which requires flexibility for decision-making and integration for management control. Twenty-one interviews with business controllers in eleven leading for-profit organi

Rotor-stator mixers (RSMs) can be operated in either batch or inline mode. When operating a rotor-stator geometry in batch mode, it typically experiences an order of magnitude higher volumetric flow through the stator than in inline mode. This is expected to cause differences in the flow and turbulence in the rotor-stator region. This study uses computational fluid dynamics (CFD) to study the hydr

Soil organic matter (SOM) supports the Earth's ability to sustain terrestrial ecosystems, provide food and fiber, and retains the largest pool of actively cycling carbon. Over 75% of the soil organic carbon (SOC) in the top meter of soil is directly affected by human land use. Large land areas have lost SOC as a result of land use practices, yet there are compensatory opportunities to enhance prod

Twenty Apolipoprotein A-I (ApoA-I) variants are responsible for a systemic hereditary amyloidosis in which protein fibrils can accumulate in different organs, leading to their failure. Several ApoA-I amyloidogenic mutations are also associated with hypoalphalipoproteinemia, low ApoA-I and high-density lipoprotein (HDL)-cholesterol plasma levels; however, subjects affected by ApoA-I-related amyloid

"Doing business", being the layman expression for "performing economic transactions", seems organised along a few logical principles. This text is about organisation in general and the vertical coordination of economic transactions in particular. Transaction cost theory, as provided by Oliver E. Williamson (1975, 1985, 1996), is used as the theoretical framework. The operationalisation of transact

During the winter and spring of 2006, Denmark and Scandinavia faced its most serious crisis since World War II. The conflict started as a Danish newspaper published a number of cartoons, some of which portrayed the prophet Muhammad. After the Danish government rejected their requests to censor the media, Danish Islamists distributed these pictures to some senior political and religious figures in