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Osteoarthritis (OA) is a common musculoskeletal disease that leads to deterioration of articular cartilage, joint pain, and decreased quality of life. When OA develops after a joint injury, it is designated as post-traumatic OA (PTOA). The etiology of PTOA remains poorly understood, but it is known that proteoglycan (PG) loss, cell dysfunction, and cell death in cartilage are among the first signs

Highly oxygenated multifunctional compounds (HOMs) play a key role in new particle formation (NPF), but their quantitative roles in different environments of the globe have not been well studied yet. Frequent NPF events were observed at two flagship stations under different environmental conditions, i.e. a remote boreal forest site (SMEAR II) in Finland and a suburban site (SORPES) in polluted eas

This practice-based PhD project investigates the conditions for a pedagogy of the utopian image in contemporary art and film. It starts from the premise that there is a need for new political and social visions and scenarios. The project asks what role art and artist film, both as a medium and as a social activity, can play in experimenting with and sketching such visions and scenarios – a process

Numerous imaging methods have been developed over recent years in order to study materials at the nanoscale. Within this context, scanning X-ray diffraction microscopy has become a routine technique, giving access to structural properties with sub-micrometre resolution. This article presents an optimized technique and an associated software package which have been implemented at the ID01 beamline

Interest in learning in mature adulthood has become increasingly important as attention has been focused on what is seen to be an impending crisis in the near future, i.e., shortage of labour due to the ever-growing number of elderly and decreasing nativity rates. In some circles "alarmist demographics" have overshadowed an arguably more important concern, that of providing for aging individuals'

The Öresund Region, which encompasses a population of 3.5 million across Southern Sweden and Eastern Denmark, aims to be a regional ”powerhouse” in Europe for sustainability, innovation and clean-tech. It can therefore provide a ”laboratory” by which to experiment, implement, examine and evaluate the progress of (local) transition governance and infrastructural investments. The Urban Transition Ör

Popular Abstract in Swedish Det finns flera avancerade datormodeller att tillgå för att analysera och utvärdera brandsäkerheten i byggnader i samband med nyproduktion och ombyggnad. Denna typ av datormodeller kan, i många fall, göra bra förutsägelser av faktorer som är betydelsefulla för brandsäkerheten och därför är de viktiga verktyg vid brandtekniska analyser. Datormodellerna är dock komplexa o

Soft Magnetic Composites (SMC) based on iron powder have a strong potential for improving both the performance and the manufacturing of various electromagnetic components and devices, such as inductors, induction heaters and electrical machines. A new casting or moulding method we have developed makes use of a modified composite, termed SM2C, or soft magnetic mouldable composite. Use of it makes i

The closed chamber technique is widely used to measure the exchange of methane (CH4) and carbon dioxide (CO2) from terrestrial ecosystems. There is, however, large uncertainty about which model should be used to calculate the gas flux from the measured gas concentrations. Due to experimental uncertainties the simple linear regression model (first-order polynomial) is often applied, even though the

A major challenge when designing general purpose graphics hardware is to allow efficient access to texture data. Although different rendering paradigms vary with respect to their data access patterns, there is no flexibility when it comes to data caching provided by the graphics architecture. In this paper we focus on volume ray-casting, and show the benefits of algorithm-aware data caching. Our M

Popular Abstract in Swedish Företagen har mer och mer problem att generera och utveckla kunskaper i samarbete med andra, enskilda företag. Forskare inom det teoretiska område kooperativ inlärning har börjat att undersöka hur partnerorganisationer lär sig att samarbeta med varandra. Men det specifika inlärningsinnehållet av denna kollektivt inlärda kunskap är generellt inte något de fokuserar på. DBusiness organizations increasingly face the problem of how to generate and share knowledge in collaboration with other, separate, business organizations. Researchers in the field of inter-organizational learning have started to study the partner-characteristic, partner-dynamic, and partner-situational factors that influence the process and outcome of such strategic learning collaboration. However

Video-on-Demand (VoD) and video sharing services account for a large percentage of the total downstream Internet traffic. In order to provide a better understanding of the load on these services, we analyze and model a workload trace from a VoD service provided by a major Swedish TV broadcaster. The trace contains over half a million requests generated by more than 20000 unique users. Among other

Sweden is part of a small European minority in the perceived societal gain of PPP. After a pilot PPP project in late 1990’s no additional project has been started in Sweden. Although there is interest from both public infrastructure clients and construction companies the national government has very clearly stated that infrastructure projects should be procured in a traditional way where all fundi

The HOO radical is a key intermediate in the atmosphere and is involved in a large number of reactions, including ozone loss cycles in the stratosphere and oxidation processes in the troposphere. This theses is a study of the HOO radical and its interactions with a number of small molecules that are present in the atmosphere. The HOO complexes were formed on the surface of growing argon matrices

Lignocellulosic biomass can be utilized to produce ethanol, a promising alternative energy source produced through fermentation of sugars. However, in order to achieve high sugar and ethanol yields, the lignocellulosic material must be pretreated before the enzymatic hydrolysis and fermentation. Dilute acid pretreatment, using SO2, is one of the most promising methods of pretreatment for softwood

Muscle atrophy, a significant characteristic of congenital muscular dystrophy with laminin α2 chain deficiency (also known as MDC1A), occurs by a change in the normal balance between protein synthesis and protein degradation. The ubiquitin-proteasome system plays a key role in protein degradation in skeletal muscle cells. In order to identify new targets for drug therapy against MDC1A, we have inv

Kajsa Sennemark Aldman Klimatförändringar och tillgång på mat i södra Afrika vid år 2050 Vi är alla är beroende av tillgång på mat för att överleva. I framtiden kan matproduktionen i världen bli hotad av förändringar i klimatet och därmed bli ett hot för många människors överlevnad. Genom att redan idag försöka ta reda på hur klimatet i framtiden kan komma att se ut, och hur det kan komma att påThe reality of climate change and the substantial impact it can have on our environment and social systems in the future is globally recognized. Intergovernmental Panel on Climate Change (IPCC) have acknowledged that global warming will lead to higher temperature and less precipitation and that it will have an effect on food safety, especially in developing countries. The aim of this study is to i

For many polar organic micropollutants, biotransformation by activated sludge microorganisms is a major removal process during wastewater treatment. However, our current understanding of how wastewater treatment operations influence microbial communities and their micropollutant biotransformation potential is limited, leaving major parts of observed variability in biotransformation rates across tr

Although conventional computer technology made a huge leap forward in the past decade, a vast number of computational problems remain inaccessible due to their inherently complex nature. One solution to deal with this computational complexity is to highly parallelize computations and to explore new technologies beyond semiconductor computers. Here, we report on initial results leading to a device

This work aims to study the effect of fuel inhomogeneity on the ignition process and subsequent combustion in a compression ignition Partially Premixed Combustion (PPC) engine using a primary reference fuel (PRF) in low load conditions. Five cases with injection timings ranging from the start of injection (SOI) at -70 crank angle degrees (CAD) to -17 CAD have been studied numerically and experimen