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IMPORTANCE: Chronic breathlessness is common in people with chronic obstructive pulmonary disease (COPD). Regular, low-dose, extended-release morphine may relieve breathlessness, but evidence about its efficacy and dosing is needed.OBJECTIVE: To determine the effect of different doses of extended-release morphine on worst breathlessness in people with COPD after 1 week of treatment.DESIGN, SETTING

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Naturally occurring plant cellulose, our most abundant renewable resource, consists of fibers of long polymer chains that are tightly packed in parallel arrays in either of two crystal phases collectively referred to as cellulose I. During mercerization, a process that involves treatment with sodium hydroxide, cellulose goes through a conversion to another crystal form called cellulose II, within

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The structure of small metal crystals has been intensively examined by high-resolution electron microscopy (HREM). In particular, multiply-twinned gold and silver crystals have been characterized using the profile-imaging method1,2 at atomic resolution, and reconstructed metal surfaces observed2. Crystal structure images of large gold clusters consisting of 55 gold atoms arranged in a cubeoctahedr

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Objective: To study the impact of GH dose and age at GH start in girls with Turner syndrome (TS), aiming for normal height and age at pubertal onset (PO) and at adult height (AH). However, age at diagnosis will limit treatment possibilities. Methods: National multicenter investigator-initiated studies (TNR 87-052-01 and TNR 88-072) in girls with TS, age 3–16 years at GH start during year 1987–1998

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The global demand for ultralow-temperature (ULT) refrigeration units gets greatly promoted, for storage, transportation, and distribution of COVID-19 vaccines. In this work, a ULT freezer is developed with a cascade refrigeration system (CRS) utilizing environmentally friendly refrigerants R290 and R170. The performance of the ULT freezer is experimentally evaluated under different ambient tempera

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Concussion is a frequent injury in many sports and is also common in para athletes. However, there is a paucity of concussion research related to para sport, and prior International Concussion in Sport (CIS) consensus papers have not substantively addressed this population. To remedy this and to improve concussion care provided to para athletes, the concussion in para sport (CIPS) multidisciplinar

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Importance: Trastuzumab emtansine (T-DM1) is presently approved for treatment of advanced breast cancer and after incomplete response to neoadjuvant therapy, but the potential of T-DM1 as monotherapy is so far unknown. Objective: To assess pathologic complete response (pCR) to standard neoadjuvant therapy of combination docetaxel, trastuzumab, and pertuzumab (DTP) vs T-DM1 monotherapy in patients

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Background/Purpose: The aim of this study was to estimate the incidence rate and prevalence of coronary artery diseases (CAD) in patients with temporal artery positive giant cell arteritis (TAB+GCA) from a defined population in southern Sweden, and to describe characteristics of CAD in this sample.Methods: The study cohort consisted of 1202 patients (71.9% women) diagnosed with TAB+GCA between 199

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Surrogate measures of safety (SMoS) are meant to function as tools to investigate traffic safety. The term surrogate indicates that these measures do not rely on crash data; instead, they focus on identifying safety critical events (or near-crashes) in traffic, which can be used as an alternative to crash records. The overall aim of this thesis is to explore which SMoS are suitable when analysing

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Under det senaste året har en rad uppmärksammade händelser med kopplingar till nazistiska grupper, som t.ex. demonstrationer och brutala överfall, ägt rum i Sverige. Dessutom har media vid ett flertal tillfällen rapporterat om att Sverige upprepade gånger kritiserats av FN:s rasdiskrimineringskommitté (CERD). Kritiken har handlat om att landet inte har rättat sig efter art. 4 (b) i FN:s internatioIn the last year a number of notable events with ties to Nazi groups, such as demonstrations and brutal attacks, have occurred in Sweden. The media has also reported on numerous occasions that the UN Committee for the Elimination of Racial Discrimination (CERD) has repeatedly criticized Sweden. The criticism has focused on the fact that the country has not complied with Article 4 (b) of the UN Con

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Det kan anses otillfredsställande att döma den som har haft en central och avgörande roll i brottet, även utan fysisk närvaro och fysiskt bidrag vid brottstillfället, som medverkande. Varken den svenska lagstiftaren eller rättspraxis har ställt upp tydliga kriterier för (med)gärningsmannaskap. I NJA 2006 s. 535 gjorde Högsta domstolen ett varsamt försök att uppställa vissa kriterier/utgångspunkterThe Swedish law has not set forth any evident and accurate criteria for (co-)perpetration. The minimum requirement for (co-)perpetration in Swedish law is support/encouragement and a decisive influence on the occurrence of the crime. Should the person who is the “mastermind” behind the crime but is not physically present or hasn’t physically contributed at the commission of the crime be regarded a

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År 2015 blev ett rekordår för Sverige vad gäller immigration. 163 000 människor sökte asyl i landet varav omkring 35 000 av dem var ensamkommande flyktingbarn. De omfattande flyktingströmmarna kom att påverka Migrationsverkets handläggningstid på asylärenden vilket resulterat i långa handläggningstider och försenade beslut. Dessa omständigheter har vidare lett till att de ensamkommande barnen hunnWhen it comes to immigration, the year of 2015 became a record year for Sweden. In 2015, 163 000 people applied for asylum in Sweden, of whom about 35 000 of them, were unaccompanied refugee children. The extensive inflow of refugees had a comprehensive impact on the Migration Agency and its timeframes for processing the applications for asylum. This resulted in extended processing times and delay

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Empowerment is a well-known slogan that symbolizes the struggle of marginalized groups against social injustices. This thesis is another contribution to the field of empowerment, addressing the issue of misusing public funds. Public Expenditure Tracking Survey, PETS, is a methodology that has been carried out in order to fight against this issue. In this study, the aim is to scrutinize whether PET

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Åren 2015 och 2016 har flera fall uppmärksammats där en kapitalstark hedgefond förvärvat aktier överstigande tio procent av bolag som är föremål för ett offentligt uppköpserbjudande. Syftet har varit att blockera förvärvet och framtvinga högre bud från förvärvaren. Ett sådant agerande möjliggörs av reglerna om tvångsinlösen, offentliga uppköpserbjudande och av hur hedgefonder regleras i lagstiftnDuring the years of 2015 and 2016 several cases were observed in which a hedge fund with large resources bought more than ten percent of companies that were subjects of public takeover offers. The purpose was to block the takeover in order to force the bidder to raise the offer. This kind of action is made possible by the laws and regulations regarding squeeze-outs, public takeover offers and hed

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Denna uppsats har sökt fastställa gällande rätt i frågan om när en angripen person som tidigast kan luta sig på nödvärn i sina försvarsåtgärder. Både Sveriges och Norges rättsliga lösningar på problemet har behandlats. Metoderna som har använts har varit rättsdogmatisk metod och komparativ metod. Enligt svensk rätt tillfaller nödvärnsrätt den som befinner sig under ett ”överhängande brottsligt anThe subject of this essay has been to determine the content of established law, concerning at what time an attacked person is entitled to self-defence at the earliest. Both Sweden and Norway’s legal solutions have been studied, using a legal dogmatic method, and a comparative legal method. The right to self-defence is, according to Swedish law, ensured to a person subject to an ”imminent criminal

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The availability of a “male network” of family members and/or friends may be decisive for the outcome of a woman’s asylum application. As it is recognised under the jurisprudence of ECtHR and Swedish asylum adjudicators that women, who originates from countries where societal structures maintain women’s reliance on men, are particularly vulnerable. The Migration Agency, the Swedish decision-making

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The white light LEDs of today are usually based on a blue LED and a phosphor, converting the blue light to longer wavelengths. While these phosphor-converted LEDs are extremely efficient compared to incandescent light or fluorescent light, there is still plenty of room for improvement. In the conversion between blue light and light of lower energy approximately 25-45 % of the radiant power is lost

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We live in a world built on consumerist values and a spatial rationale of capital accumulation. This modern society has led to architecture thriving through super consumption and super production ultimately leading to the generic. Cities and spaces that were usually rich in variation and texture have now become an architectural melting pot. Architecture has become smooth, simplified and reduced to