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BACKGROUND: Glibenclamide (Gb) may provoke long-lasting hypoglycaemic reactions, and one of the known risk factors is impaired renal function. We have demonstrated Gb to have a terminal elimination half-life of 15 h, and the main metabolites have a hypoglycaemic effect. With few exceptions, detailed studies on second generation sulphonylureas in diabetics with impaired renal function are lacking.
Background: Abdominal obesity is a risk factor for cardiovascular disease. The aim was to explore the influence of midnight salivary cortisol (MSC), antidepressants and sex on abdominal obesity in type 1 diabetes (T1D). We controlled for physical inactivity, smoking, depression and alexithymia. Methods: Cross sectional study of 190 T1D patients (86 women/104 men, 18-59 years, diabetes duration 1-5
The overall aim of this thesis was to increase our knowledge of engagement in occupations in persons with Multiple Sclerosis (MS) in order to develop client-centred occupational therapy and rehabilitation. In study I, observations of the performance of self-care and household occupations were pursued in 44 participants, and study II identified self-perceived problems in performance of occupations
Knowledge concerning the molecular mechanisms governing the influence of non-coding RNAs on protein production has emerged rapidly during the past decade. Today, two main research areas can be identified, one oriented toward the use of artificially introduced siRNAs for manipulation of gene expression, and the other one focused on the function of endogenous miRNAs. In both cases, the active molecu
Intermittent Parathyroid Hormone (PTH)((1-34)) has an established place in osteoporosis treatment, but also shows promising results in models of bone repair. Previous studies have been dominated by closed fracture models, where union is certain. One of the major clinical needs for anabolic therapies is the treatment of open and high energy fractures at risk of non-union. In the present study we th
Aircraft observations of precipitating clouds with cloud top temperatures higher than -38°C have revealed that Secondary Ice Production (SIP) is responsible for presence of majority of ice particles. One such SIP mechanism is fragmentation via collisions between ice particles. The central theme of this study is to understand the dependencies of this SIP mechanism and improve its existing numerical
Syftet med denna studie var att få en ökad kunskap och förståelse för de utmaningar som uppstår i biståndshandläggarnas arbete för att bedöma behovet av hjälp bland äldre i Sverige. Målet var vidare att undersöka hur arbetsprocessen har påverkats på grund av kompletterande utmaningar orsakade av pandemin. Studien baseras på kvalitativa intervjuer med sex biståndshandläggare som arbetar inom den svThe purpose of this study was to gain an increased knowledge and understanding of the challenges occurring in care managers’ work to assess needs of assistance among elderly people in Sweden. Further, the aim was to investigate how the work process has been affected due to supplementary challenges caused by the pandemic. The study is based on qualitative interviews with six care managers working w
This paper examines the role of powerful entities in shaping international accounting standards. The purpose of this thesis is to identify whether and to what extent the different actors influence changes in the leasing standard-setting process, and provide an in-depth understanding of the political influences throughout the development of the leasing accounting standard. In this paper the qualita
Title: Critical Supply Chain Factors for Scaling a Startup -- A Case Study in the Industry of Semiconductors Author: Pontus Landgren Supervisors: Bertil Nilsson, Lund University, Faculty of Engineering & Lennart Moberg, Acconeer AB Background: A well implemented supply chain strategy aligned with the company's overall strategy is a prerequisite in order to successfully scale a startup.
Lithuania like other Central and Eastern European (CEE) countries has undergone major changes from the communist socio-economic order to the system based on democratic capitalism. This shift towards market economy and the collapse of communist ideology were also reflected in higher education (HE) reforms. Since political parties are the main actors in modern democracies, partisan politics could in
Bixin is a carotenoid which is extracted from annatto (Bixa orellana). Its main application is as a coloring agent. It consists of conjugating double bonds with a carboxylic end, making it prone to degradation by oxygen, light and heat. This study investigates the light stability of bixin encapsulated with maltodextrin (MD), sucrose and whey by spray drying. MD was added with additives such as car
Epilepsy is a neurological disorder characterized by its debilitating epileptic seizures. There are generalized seizures, which affect the whole brain at once, and focal seizures, which start from one part of the brain. The most common focal epilepsy, is temporal lobe epilepsy representing almost 70% of all focal epilepsies. Around 30% of all patients are therapy refractory, therefore there is a h
BACKGROUND: Direct-to-consumer telemedicine is an increasingly used modality to access primary care. Previous research on assessment using synchronous virtual visits showed mixed results regarding antibiotic prescription rates, and research on assessment using asynchronous chat-based eVisits is lacking.OBJECTIVE: The goal of the research was to investigate if eVisit management of sore throat, othe
BackgroundAssessment and treatment of the acutely ill patient have improved by introducing systematic assessment and accelerated protocols for specific patient groups. Triage systems are widely used, but few studies have investigated the ability of the triage systems in predicting outcome in the unselected acute population. The aim of this study was to quantify the association between the main com
Importance: Prenatal diagnosis of complex congenital heart defects reduces mortality and morbidity in affected infants. However, fetal echocardiography can be limited by poor acoustic windows, and there is a need for improved diagnostic methods.Objective: To assess the clinical utility of fetal cardiovascular magnetic resonance imaging in cases in which fetal echocardiography could not visualize a
Objective: To identify factors affecting the outcome after open surgical (OSR) and endovascular (ER) repair of popliteal artery aneurysm (PA) in comparable cohorts. Methods: A matched comparison in a national, population based cohort of 592 legs treated for PA (2008 – 2012), with long term follow up. Registry data from 899 PA patients treated in 2014 – 2018 were analysed for time trends. The 77 le
Objective: To investigate how genetics influence the risk of smoking-related systemic lupus erythematosus (SLE) manifestations. Methods: Patients with SLE (ndiscovery cohort=776, nreplication cohort=836) were genotyped using the 200K Immunochip single nucleotide polymorphisms (SNP) Array (Illumina) and a custom array. Sixty SNPs with SLE association (p<5.0×10-8) were analysed. Signal transducer an
OBJECTIVE: To evaluate compliance to workflow and accuracy of tests in Sweden's first fast-track referral pathway for patients with nonspecific symptoms and suspected cancer (SCAN).DESIGN: Prospective cohort study with consecutive inclusion of patients referred to the diagnostic center (DC).SETTING: Patients with nonspecific symptoms were examined in primary care according to a protocol including
External sources such as traffic and construction work cause noise and vibration in nearby buildings, potentially annoying human residents. Today, almost every fifth European is harmfully affected by traffic noise and vibration. Wave barriers placed on or embedded within the soil between the source and the receiver can mitigate the transmission of ground vibration, and the airborne noise transmiss
