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OBJECTIVES: The safety of generic substitution of antiseizure drugs (ASDs) has been questioned for many years. This study aimed to identify physicians' attitudes to the generic substitution of ASDs in epilepsy and which factors were of significance when deciding on compound substitutions.MATERIAL AND METHODS: A cross-sectional web-based survey was sent to neurologists and neurology residents in pu
Background In addition to the diagnostic accuracy of imaging methods, patient-reported satisfaction with imaging methods is important. Objective To report a secondary outcome of the prospective international multicenter Imaging Study in Advanced ovArian Cancer (ISAAC Study), detailing patients’ experience with abdomino-pelvic ultrasound, whole-body contrast-enhanced computed tomography (CT), and w
Introduction Severe osteogenesis imperfecta (OI) is a debilitating disease with no cure or sufficiently effective treatment. Mesenchymal stem cells (MSCs) have good safety profile, show promising effects and can form bone. The Boost Brittle Bones Before Birth (BOOSTB4) trial evaluates administration of allogeneic expanded human first trimester fetal liver MSCs (BOOST cells) for OI type 3 or severe
Aim: This study aimed to investigate if younger age at diagnosis of colorectal cancer was associated with a diagnostic delay. The secondary objective was to evaluate if symptomatology varied with age. Method: The study population consisted of the cohorts from two prospective multicentre studies conducted in Sweden and Denmark, the QoLiRECT and QoLiCOL studies. These studies investigated the qualit
The present work describes the formation of low-aspect-ratio Ag nanoparticles (NPs) arrays by sequential deposition of Ag from different growth directions on a nanoripple-patterned Si substrate, produced by low-energy ion beam irradiation. It is observed that the growth of Ag-NPs on ripple surfaces is direction-dependent due to the asymmetric ridge of the ripple pattern. This asymmetric ridge can
Background: The assessment of left ventricular (LV) filling pressure in heart failure (HF) poses a diagnostic challenge, as HF patients may have normal LV filling pressures at rest but often display elevated LV filling pressures during exercise. Rapid preload increase during passive leg lift (PLL) may unmask HF in such challenging scenarios. We explored the dynamic interplay between simultaneous l
This research project explores how theatre can contribute to democratic engagement. The starting point was artistic probes investigating aspects of democracy: participation, deliberation and inclusion. The probes resulted in three productions presented at theatre institutions in Sweden. In Skapa Demokrati (Creating Democracy), participation was promoted by encouraging the audience members to creat
This paper investigates the confluence of artificial intelligence (AI), the performing arts, and emotion communication, focusing on how generative AI and social robotics – today’s forefront disruptive technologies – can facilitate an exploration of emotional dynamics across artistic mediums. Drawing on the intermedial and multimodal capacities of opera, this paper presents AI-enhanced opera as a p
This book summarises fundamental methodologies in biological soil and water conservation measures, using the versatile Vetiver grass as a prime example. The material is derived from various student compendia and extension information letters on soil science and soil and water conservation written by Associate Professor Emeritus H. Jonas Åkerman between 1980 and 2000. Over a decade of long-term ass
Efforts to develop the wild berry industry in Sweden and internationally call for increased knowledge about the consumer perspective. Our objective is to investigate attitudes, product associations, consumption patterns, and foraging behaviour regarding bilberries, with an online survey using a nationally representative sample (N = 2010). The data were analysed with regression and multinomial test
Algoritmiska rekommendationer har blivit allt mer förekommande i vardagen. Från filmer, musik och potentiella partners till söta katter och roliga danser – sociala medieplattformar utvecklar kraftfulla algoritmer för att förutsäga vad användarna kommer tycka om och behöva. Algoritmiska rekommendationer föreslår dock inte samma innehåll till alla användare, utan anpassar sina rekommendationer dynamAlgorithmic recommendations have become ubiquitous in everyday life. From films, music, and potential partners to cute cats and silly dances, social media platforms develop powerful algorithms to predict what users might like and need. However, algorithmic recommendations do not suggest the same content to all users but instead adapt their recommendations dynamically through endless feedback loops
This thesis gives a contribution to matching theory. It examines three one-to-one matching models: the roommate problem, the partnership formation problem and the assignment game. In the former two, it is known that stable matchings may not exist. In the latter, stable outcomes do exist; we examine if they still do if we generalize the model. The thesis consists of three separate papers. In the f
Attention Restoration Theory point to nature as a particularly good candidate for restoring the ability to focus and inhibit distractions. However, little effort has been directed to elaborating on what makes nature's visual pattern unique for restoration purposes. One suggested explanation is the fractal properties of natural patterns (Hagerhall, 2005). Both perception studies (Hagerhall et al.,
Introduction: The lungs are the second most common site for metachronous metastases in colorectal cancer. No treatment algorithm is established, and the role of adjuvant chemotherapy is unclear. This study aimed to map pulmonary recurrences in a modern multimodal treated population, and to evaluate survival depending on management. Methods: Retrospective study based on the COLOFOL-trial population
Background and purpose: Stereotactic radiosurgery (SRS) requires high positional accuracy to safely deliver large doses. This study evaluated an integrated surface- and image-guided radiotherapy (SGRT-IGRT) system by analysing (1) the agreement between thermo-optical and stereoscopic X-ray positioning, and (2) the impact of intra-fractional workflows on treatment accuracy and time. Materials and m
OBJECTIVES: The aim of this prospective study was to contribute to the evaluation of the reliability of Duplex sonography (DS) before carotid endarterectomy (CEA). DESIGN: The study was performed prospectively in a university hospital setting. METHODS: Eighty-one consecutive patients aged 49-83 years were examined with DS and carotid angiography (CAG) before CEA. The results of the DS were judged
1. Mechanical transients in fibre bundles of skinned smooth muscle of guinea-pig taenia coli at 21-22 degrees C were investigated by recording tension responses to length changes of up to 9%, complete within 0.3 ms. 2. The length-force relationship, recorded continuously during rapid stretch of a Ca(2+)-activated contracted muscle, was linear up to at least 2.5 times the isometric force, correspon
Aims: Fluorescence in situ hybridization (FISH) can be used to reveal several genomic imbalances relevant to proper cancer diagnosis and to the correct treatment regime. However, FISH requires expensive and advanced fluorescence microscopes in addition to expertise in fluorescence microscopy. To determine whether a newly developed dual-colour chromogenic in situ hybridization (CISH) method is a su
Laboratory studies of scatter hoarding birds have become a model system for spatial memory studies. Considering that such birds are known to have a good spatial memory, recovery success in lab studies seems low. In parids (titmice and chickadees) typically ranging between 25 and 60% if five seeds are cached in 50-128 available caching sites. Since these birds store many thousands of food items in
