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In Parkinson's disease (PD), there is accumulation of α-synuclein (SYN) aggregates in neurons, which is promoted by neuroinflammation. The cytokines TNF-α, IL-1β and IL-6 induce accumulation of degradation products of the amyloid precursor protein (APP) combined with heparan sulfate (HS) chains released from glypican-1 (Gpc-1) by NO-dependent cleavage. We have investigated the effects of the cytok

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We construct an annual index of Irish industrial output for 1800-1921, the period during which the entire island was in a political Union with Great Britain. We also construct a new industrial price index. Irish industrial output grew by an average of 1.4 per cent per annum over the period as a whole, and by 1.8 per cent per annum between 1800 and the outbreak of World War I. Industrial growth was

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Processing of lignocellulosic biomass is complex due to the heterogeneity of the substrate, but also due to lengthy unit operations, which complicates process control including for enzymatic saccharification. Methods for predicting enzymatic saccharification yield based on the properties of the pretreated biomass would be advantageous to process optimization and control. Biomass-water interaction

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Purpose – This study aims to explore how an accessibility database (AD) has been developed and implemented as a tool for facility managers to evaluate and increase the accessibility of public facilities.Design/methodology/approach – Eight participants were strategically sampled for semi-structured interviews, and documents on the AD were gathered. The Consolidated Framework for Implementation ResePurpose – This study aims to explore how an accessibility database (AD) has been developed and implemented as a tool for facility managers to evaluate and increase the accessibility of public facilities.Design/methodology/approach – Eight participants were strategically sampled for semi-structured interviews, and documents on the AD were gathered. The Consolidated Framework for Implementation Rese

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Fibril-reinforced poroviscoelastic material models are considered state-of-the-art in modeling articular cartilage biomechanics. Yet, cartilage material parameters are often based on bovine tissue properties in computational knee joint models, although bovine properties are distinctly different from those of humans. Thus, we aimed to investigate how cartilage mechanical responses are affected in t

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Snakebite envenomations has for a long time been an overlooked problem, despite the hundreds of thousands of deaths and disabilities caused by this disease each year. However, since snakebite envenoming predominantly affects the rural areas of third-world countries, there was an absence of research funding and drive to address this profound concern. Consequently, costly and often highly immunogeni

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Financial return series are often characterized by volatility clusters and a leptokurtic distribution. Many models that account for these properties exist, with the GARCH model proposed by Bollerslev (1986) being the most popular. This thesis explores an alternative model to capture the stochastic volatility in financial time series. The considered model is denoted the autoregressive gamma varianc

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Med minskade resurser av fossila bränslen och ökade miljökrav har förnybara ersättningar fått större uppmärksamhet. Produktionen av förnybara kemikalier och bränslen genom förgasning av biomassa är en lovande lösning för att driva denna energiomställning. Syntesgas (syngas), en blandning av främst CO och H2, kan framställas av biomassa via förgasning. Biologisk me-tanisering, som ett potentiellt aWith reduced resources of fossil fuels and increased environmental requirements, renewable substitutes have received greater attention. The production of renewable chemicals and fuels through biomass gasification presents a promising route to drive this energy transition. Synthe-sis gas (syngas), a mixture of mainly CO and H2, can be produced from biomass via gasifica-tion. Biological methanation,

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Children affected by the multisystem genetic disorder Hutchinson-Gilford Progeria Syndrome look prematurely aged, suffer from elderly-related conditions and die during adolescence due to cardiovascular complications. The cause of the disease is single point gain-of-function mutations in the LMNA gene, which encodes the lamin A and lamin C proteins, major components of the nuclear lamina. These mut

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Befriande klang och laddad tystnad – prepareringar i pianoimprovisation som en väg till kreativ didaktik av Rui Hallvares Andrade Paes. Detta arbete syftar till att erbjuda ny kunskap om användningsmöjligheter av prepareringar i improvisation, övning och pianoundervisning. Den metodiska utgångspunkten är tredelad, och innefattar (i) en personlig processtudie av prepareringar i musicerande och imp

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Det finns olika teorier kring vem som bevisbördan ska falla på inom tvistemål när det råder oenighet kring huruvida ett visst rättsfaktum ligger för handen. Bevissäkringsteorin är en av dessa. Bevissäkringsteorin innebär att bevisbördan läggs på den som har haft det lättast för att säkra bevisning. Mot bevissäkringsteorin konkurrerar de materiella bevisteorierna. Dessa teorier förespråkar att beviThere are different theories regarding who should carry the burden of proof within civil cases when there is controversy regarding whether or not a certain fact is at hand. The theory of securing evidence is one of these. The theory of securing evidence states that the burden of proof should be placed on whomever has an easier time of securing evidence. The material theories of evidence compete wi

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Syftet med denna studie var att undersöka hur biståndshandläggare inom äldreomsorgen upplever och beskriver den inverkan som pandemins restriktioner har haft på sättet att kommunicera och samtala med äldre under Covid-19 och vilka förändringar som uteblivna hembesök har medfört. Studien och dess resultat bygger på en kvalitativ undersökning i form av sju semistrukturerade intervjuer med biståndshaThe aim of this study was to investigate how case managers in the eldercare experience and describe the effect that the pandemic restrictions have had on communication and on the ways case managers communicate with the elderly and what changes absent home visits have caused. The study and its results are based on seven qualitative interviews with case managers in Sweden. Thematic analysis has been

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Multimedia environments consist of verbal and visual representations that, if appropriately processed, allow for the construction of an integrated mental model of the content. Whereas much is known on how students learn from verbal representations, there are fewer insights regarding the processing of visual information, alone or in conjunction with text. This chapter uses a semiotics approach to p

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Multimedia environments consist of verbal and visual representations that, if appropriately processed, allow for the construction of an integrated mental model of the content. Whereas much is known on how students learn from verbal representations, there are fewer insights regarding the processing of visual information, alone or in conjunction with text. This chapter uses a semiotics approach to p

Verksamhetsberattelse-2021

Centrum för handelsforskning vid Lunds universitet VERKSAMHETSBERÄTTELSE | 2021 2 VERKSAMHETSBERÄTTELSE CENTRUM FÖR HANDELSFORSKNING 2021 Inledning Centrum för handelsforskning – det åttonde året För oss precis som för många andra har 2021 varit ytterligare ett speciellt år. Corona har utmanat oss, på många olika sätt. Detta år har vi dock varit lite mer förberedda och inövade på att hitta onlinel

https://www.lusem.lu.se/sites/lusem.lu.se/files/2024-01/verksamhetsberattelse-2021.pdf - 2026-07-13