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Non-technical summary The United Nations' sustainable development goals (SDGs) articulate societal aspirations for people and our planet. Many scientists have criticised the SDGs and some have suggested that a better understanding of the complex interactions between society and the environment should underpin the next global development agenda. We further this discussion through the theory of soci
The existing information supports the use of this material as described in this safety assessment. Dihydrocarvyl acetate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analogs dihydrocarveol (isomer unspecified) (CAS # 619-01-2) and aceti
The tumor suppressor gene p53 can mediate both apoptosis and cell cycle arrest. In addition, p53 also influences differentiation. To further characterize the differentiation inducing properties of p53, we overexpressed a temperature-inducible p53 mutant (ptsp53Val135) in the erythroleukemia cell line K562. The results show that wild-type p53 and hemin synergistically induce erythroid differentiati
Butyl 10-undecenoate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog methyl undec-10-enoate (CAS # 111-81-9) show that butyl 10-undecenoate is not expected to be genotoxic. Data on butyl 10-undecenoate and read-across analog methyl
The use of this material under current use conditions is supported by the existing information.This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog, benzyl acetate (CAS # 140-11-4), show that this m
Background T-cell activation and clonal expansion are essential to effective immunotherapy responses in non-small cell lung cancer (NSCLC). The distribution of T-cell clones may offer insights into immunogenic mechanisms and imply potential prognostic and predictive information. Methods We analyzed α/β T-cell receptor (TCR) clonality using RNA-sequencing of bulk frozen tumor tissue from 182 patien
PII: 0006-8993(81)91007-6 Brain Research, 229 (1981) 457-470 457 Elsevier/North-Holland Biomedical Press B E H A V I O U R A L RECOVERY F O L L O W I N G T R A N S P L A N T A T I O N OF SUBS- T A N T I A N I G R A IN RATS SUBJECTED TO 6-OHDA LESIONS OF T H E N I G R O S T R I A T A L PATHWAY. II. B ILATERAL LESIONS STEPHEN B. DUNNETT*, ANDERS BJORKLUND, ULF STENEVI and SUSAN D. IVERSEN Department
https://www.wnc.lu.se/sites/wnc.lu.se/files/dunnett_et_al_part_ii_brain_res_1981.pdf - 2026-07-23
This study reports the status of the first in-beam γ-ray spectroscopic study of excited states in the exotic neutron-deficient Tz=-3/2 nucleus 55Cu. The nucleus was produced via knock-out reactions at the Radioactive Isotope Beam Factory, located at the RIKEN-Nishina Center. Several γ-ray transitions were detected using the DALI2+ γ-ray detector array. The comparison with isobaric analogue states
