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Background Molecular DNA sequence data allow unprecedented advances in biodiversity assessments, monitoring schemes and taxonomic works, particularly in poorly-explored areas. They allow, for instance, the sorting of material rapidly into operational taxonomic units (such as BINs - Barcode Index Numbers), sequences can be subject to diverse analyses and, with linked metadata and physical vouchers,
Although there are some epigenome-wide association studies (EWAS) of insulin resistance, most of them did not replicate their findings and are focused in populations of European ancestry limiting the generalizability. In EPIPREG (294 Europeans and 162 South Asians), we conducted an EWAS of insulin resistance in maternal peripheral blood leukocytes, with replication in Born in Bradford (n=879; 430
Optically stimulated luminescence (OSL) and radiocarbon (14C) techniques were employed to investigate the absolute ages of alluvial sediments in Podhale in the West Carpathians, southern Poland. This is an approach to (i) testing the credibility of the above dating methods by their reciprocal age control and (ii) further implications to regional geochronology and to dating campaigns of alluvial se
Increasing loading of terrestrially derived dissolved organic matter tends to enhance bacterioplankton respiration (BR) in boreal estuaries, but knowledge on the mechanisms behind this effect is not complete. We determined the stable isotopic signature of the reactive estuarine dissolved organic carbon (DOC) in the Öre estuary (Baltic Sea) by using the Keeling plot method. The δ13C ratio of the es
Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, but the nature of the suggestive comorbidity is still unknown. We used a novel genetic pleiotropy-informed conditional False Discovery Rate (FDR) method to identify single nucl
Wildland-urban interface (WUI) fire incidents are likely to become more severe and will affect more and more people. Given their scale and complexity, WUI incidents require a multidomain approach to assess their impact and the effectiveness of any mitigation efforts. The authors recently produced a specification for a simulation framework that quantifies evacuation performance during WUI incidents
Throughout different eras and cultures what is considered the cosmetically ideal breast has varied greatly. There is no broadly accepted standardised method that objectively evaluates aesthetic outcome after breast reduction mammoplasty. The primary aim of this study was to evaluate the result of breast reduction regarding nipple position, comparing it to an objective previously described standard
BACKGROUND: Hyperthyroidism is associated with alterations in metabolism that are currently only partially understood. The objective of the study was to investigate changes in metabolism associated with reinstatement of euthyroidism in Swedish patients.METHODS: Eighty metabolites in plasma were profiled from 10 subjects with Graves' disease (GD) at baseline and after 9 and 15 months of treatment t
Natural hybridization occurs commonly in plants and blurs their interspecific delimitation. It is unclear whether spontaneous hybridization occurs in natural populations of Primula in China. In this study we examined natural hybridization between P. secundiflora and P. poissonii based on morphological and molecular analyses of individuals with intermediate morphology. Most morphological characters
The effects of insulin (10-1000 microU ml-1) on chylomicron remnant uptake and degradation were studied in hepatocyte monolayer cultures. Both uptake and degradation were stimulated by insulin. The degree of stimulation was influenced by cell density, being most pronounced in sparse cultures. The uptake was stimulated in a dose-dependent fashion and was noticed already at a physiological insulin l
The stereoselective reduction of ketones catalysed by alcohol dehydrogenase from Thermoanaerobium brockii was studied in different reaction media, hexane at controlled water activities, hexane with 2.5% water (biphasic) and pure water. The reactions were studied in the temperature range from -1 to 50°C. Increasing the water activity from 0.53 to 0.97 increased the reaction rate 16-fold. The rate w
To study the frequency of diabetic retinopathy in relation to age at diagnosis, treatment, duration of diabetes and glycemic control as measured by means of HbA(1c) levels, we performed a cross-sectional, register-based study in the Helsingborg area of southern Sweden, comprising 2232 diabetic patients. Of the known diabetic population < 75 years old, approximately 70% were estimated to be include
We present a new methodology involving the simultaneous refinement of both x-ray absorption and x-ray diffraction spectra (x-ray absorption/diffraction structural refinement, XADSR) to study the hydration and ion pair structure of CaCl2 and RbBr salts in concentrated aqueous solutions. The XADSR method combines the x-ray absorption fine structure (XAFS) spectral analysis of both the cation and ani
Background: How we identify ourselves is strongly related to employment. Young adults are a vulnerable group with regard to entering the Labor market. If they also have mental health problems, entering becomes more difficult and increases risk of early marginalization. Nevertheless, working can be essential for personal recovery process. Aims: To explore experiences of young adults with mental hea
