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Lipid nanoparticles (LNPs) are the most versatile and successful gene delivery systems, notably highlighted by their use in vaccines against COVID-19. LNPs have a well-defined core–shell structure, each region with its own distinctive compositions, suited for a wide range of in vivo delivery applications. Here, we discuss how a detailed knowledge of LNP structure can guide LNP formulation to impro
We report the discovery of a hot (Teq ≈ 1055 K) planet in the small-planet radius valley that transits the Sun-like star TOI-733. It was discovered as part of the KESPRINT follow-up program of TESS planets carried out with the HARPS spectrograph. TESS photometry from sectors 9 and 36 yields an orbital period of {equation presented} days and a radius of {equation presented}. Multi-dimensional Gauss
The suitability of Hansen solubility parameters as descriptors for modelling analyte retention during reversed-phase chromatographic experiments was investigated. A novel theoretical model using Hansen solubility parameters as the basis for a complete mathematical derivation of the model was developed. The theoretical model also includes the cavitation volumes of the analytes, which were calculate
Aftershock rates seem to follow a power law decay, but the assessment of the aftershock frequency immediately after an earthquake, as well as during the evolution of a seismic excitation remains a demand for the imminent seismic hazard. The purpose of this work is to study the temporal distribution of triggered earthquakes in short time scales following a strong event, and thus a multiple seismic
In this fascinating biography of the Indian revolutionary M. P. T. Acharya (1887–1954), Ole Birk Laursen uncovers the remarkable transnational networks, movements and activities of India’s most important anticolonial anarchist in the twentieth century.Driven by the urge for complete freedom from colonialism, authoritarianism, fascism and militarism, which are rooted in the idea and politics of the
Despite the recent experimental and theoretical progress in the investigation of the nuclear fission process, a complete description still represents a challenge in nuclear physics because it is a very complex dynamical process, whose description involves the coupling between intrinsic and collective degrees of freedom, as well as different quantum-mechanical phenomena. To improve on the existing
Hazardous materials in buildings cause project uncertainty concerning schedule and cost estimation, and hinder material recovery in renovation and demolition. The study aims to identify patterns and extent of polychlorinated biphenyls (PCBs) and asbestos materials in the Swedish building stock to assess their potential presence in pre-demolition audits. Statistics and machine learning pipelines we
BACKGROUND: Numerous laboratory tests are used in the diagnosis and management of diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially. APPROACH: An expert committee compiled evidence-based recommendations for laboratory analysis in screening, diagnosis, or monitoring of diabetes. The overall quality of the evidence and the strength of t
This article conceptualizes evolutionary theory as a bridge between existing theorizing in strategic communication on the one hand, the mind sciences on the other. It discusses six core concepts of evolutionary psychology that have a bearing on strategic communication theory: a) the human as a highly flexible social species; b) the regulation of individually-minded vs. collectively-minded behavior
Popular Abstract in Swedish Mekanisk ventilation kan medföra "ventilationsinducerad lungskada" (VILI), som kan öka sjuklighet och dödlighet i samband med akut lungskada (ALI). Flera ventilationssätt har föreslagits för att undvika VILI, men inte slutgiltigt utvärderats. En princip är att öka alveolär ventilation och CO2-elimination genom att minska ventilationen av de skadliga rummet, dead space. Ventilator-induced lung injury (VILI) may contribute to morbidity and mortality of acute lung injury (ALI). Lung protective ventilation (LPV), that reduces VILI, may involve low tidal volume (Vt). Particularly low Vt is possible if dead space ventilation is reduced e.g. by aspiration of dead space gas (ASPIDS). ASPIDS implies that gas rich in CO2 during expiration is aspirated through a separate c
Popular Abstract in Swedish Den största källan till läkemedelsrester i vattenmiljön är utgående renat avloppsvatten från våra kommunala reningsverk. Läkemedel är utvecklade för att ha olika typer av biologiska effekter. Vilka dessa är i människan är relativt välkänt, medan effekterna på vattenlevande organismer och andra djur till stor del är okända. Detta i kombination med deras resistens mot de The discharge of effluents from wastewater treatment plants (WWTPs) is considered to be the major source of residual pharmaceuticals frequently found in aquatic environments. The complex nature of such compounds tends to make conventional biological treatments aimed at their removal ineffective. The present thesis concerns the removal of 62 different active pharmaceutical ingredients commonly dete
Traditionally, control loops are closed using periodic sensing and actuation. When communication resources are scarce, however, much may be gained from transmitting only when something important has happened in the loop. This paper presents a simple model of the interference between event-based control loops caused by sharing a common medium, based on the coupled dynamics of a Markov chain represe
