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District Heating is a cornerstone for the decarbonisation of the heating and cooling sector in Europe. Nonetheless, this technology is currently absent in a majority of the continent's urban areas, and hence the need for appropriate methods by which to estimate the cost, as well as underlying cost parameters, to assess the feasibility of developing district heating networks is of general interest.
INTRODUCTION: Recent clinical trials of amyloid beta (Aβ)-targeting therapies in Alzheimer's disease (AD) have demonstrated a clinical benefit over 18 months, but their long-term impact on disease trajectory is not yet understood. We propose a framework for evaluating realistic long-term scenarios. METHODS: Results from recent phase 3 trials of Aβ-targeting antibodies were integrated with an estim
A 2015 review of external examining in the UK assessed the effectiveness of the external examining system in safeguarding academic and quality standards in higher education. The development of the Professional Development Course for External Examiners was a key response to the recommendations from this review. This chapter contains an overview of the structure of the course, the key messages commu
Alzheimer’s disease can be treated by targeting amyloid-β plaques and diagnosed in vivo by biomarkers, prompting the revision of criteria for the diagnosis and staging of this disease.
Microorganisms have unique biochemical mechanisms to inhibit the growth or kill other microorganisms in the same environment. Bacterial threat agents (BTA) are more effective than conventional weapons because of these characteristics, therefore, the development and production of biological weapons are still relevant. Early warning signals need to be obtained for fast and accurate detection of BTA
Aim: To audit adherence to the Swedish paediatric guidelines for urinary tract infections (UTIs) in infants. Secondary objectives were to compare findings on imaging performed according to the guidelines with imaging without guideline support and to identify predictors of non-adherence. Methods: A prospective multicentre study of infants <1 year treated at paediatric hospitals for their first UTI.
In the context of a decarbonized future where stringent carbon dioxide (CO2) emissions constraints are imposed on vehicles, hydrogen emerges as a promising solution to address emissions directly at the point of use. This chapter explores the potential of using hydrogen to power vehicles, particularly in the context of heavy-duty (HD) internal combustion engine (ICE) applications. Hydrogen vehicles
Recent research into migration in Bangladesh has highlighted that people migrate for better livelihoods, not necessarily in response to climatic stresses and shocks. If facilitated appropriately, internal and international migration can help build adaptive capacity to future environmental and climatic hazards. In this framing, migration happens in the context of a growing city-centred economy that
Free energy calculations play a crucial role in simulating chemical processes, enzymatic reactions, and drug design. However, assessing the reliability and convergence of these calculations remains a challenge. This study focuses on single-step free-energy calculations using thermodynamic perturbation. It explores how the sample distributions influence the estimated results and evaluates the relia
We survey the current state of the art in the use of nonparametric methods to test separability. We focus on three tests: Swofford and Whitney's (1994) joint test of the necessary and sufficient conditions for weak separability; Fleissig and Whitney's (2003) sequential test of those conditions; and Jones and Stracca's (2006) test of the necessary and sufficient conditions for additive separability
The ATLAS detector is installed in its experimental cavern at Point 1 of the CERN Large Hadron Collider. During Run 2 of the LHC, a luminosity of ℒ = 2 × 1034 cm-2 s-1 was routinely achieved at the start of fills, twice the design luminosity. For Run 3, accelerator improvements, notably luminosity levelling, allow sustained running at an instantaneous luminosity of ℒ = 2 × 1034 cm-2 s-1, with an a
Despite the successes in the use of artificial intelligence systems for image analysis, in certain critical applications, the final decision-making should remain with the human operator. To facilitate the working conditions of an unmanned aerial vehicle (UAV) pilot during prolonged missions, an auxiliary narrow-angle video camera is installed on board the UAV. This camera can be positioned indepen
Explaining the maintenance of genetic variation in fitness-related traits within populations is a fundamental challenge in ecology and evolutionary biology. Frequency-dependent selection (FDS) is one mechanism that can maintain such variation, especially when selection favours rare variants (negative FDS). However, our general knowledge about the occurrence of FDS, its strength and direction remai
Blog for the European Network on Statelessness on the impact of the temporary asylum law on the resolution of statelessness of refugees.
Let f be a holomorphic self-map of the unit disc. We show that if log(1−|f(z)|) is integrable on a sub-arc of the unit circle, I, then the set of Carathéodory angular derivatives of f on I is a countable union of Beurling-Carleson sets of finite entropy. Conversely, given a countable union of Beurling-Carleson sets, E, we construct a holomorphic self-map of the unit disc, such that its set of Cara
Differential equations are an important building block for modeling processes in physics, biology, and social sciences. Usually, their exact solution is not known explicitly though. Therefore, numerical schemes to approximate the solution are of great importance. In this thesis, we consider the temporal approximation of nonlinear, nonautonomous evolution equations on a finite time horizon. We pres
The Dirichlet–Neumann alternating method is a common domain decomposition method for nonoverlapping domain decompositions without cross-points, and the method has been studied extensively for linear elliptic equations. However, for nonlinear elliptic equations, there are only convergence results for some specific cases in one spatial dimension. The aim of this manuscript is therefore to prove that
