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Friedreich’s ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by defeciency in frataxin, a highly conserved protein central to iron homeostasis in mirochondria. The function of frataxin is related to its capability to bind, store and deliver iron to different biochemical process such as iron-sulfur cluster assembly and heme biosynthesis. Most FRDA pateints have extended GAA

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An increasing number of disasters continue to affect urban populations and housing infrastructure. The overwhelming majority of them have been caused by climate-related events. This situation has made the creation of synergies between climate change adaptation (CCA) and disaster risk management (DRM) urgent. Despite the recognised need to unite CCA and DRM efforts, the fields remain separate. Furt

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En grundläggande utgångspunkt i både den kontradiktoriska rättegången inför allmän domstol och i skiljeförfarande är att parterna svarar för bevisningen. Eftersom tillgången till relevant bevisning ofta är avgörande för utgången i en tvist, är möjligheten att göra gällande en motparts eller tredje mans processuella editionsplikt av central betydelse för en informationsfattig part. Vid framställa

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Manufacturing of biopharmaceuticals is a costly and time consuming process due to its inherent complexity and variability. The downstream process is the most expensive part and it involves multiple non-trivial steps. Continuous integrated manufacturing is a new concept that is encouraged by authorities. The advantages include uninterrupted operation, automation, consistent product quality, lower r