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BACKGROUND: Counting very low levels of leukocytes is technically challenging but mandatory for quality control of leukocyte-depleted plasma. Established assays, such as flow cytometry and counting in the Nageotte chamber, are laborious and expensive. The aim of this study was to test two alternative assays, the cerebrospinal fluid program in the routine hematology analyzer ADVIA 2120 and a fluore
Introduction: Excessive worry is common during adolescence and across a range of psychiatric conditions. There is a growing evidence base for the efficacy of cognitive behaviour therapy (CBT) in reducing the frequency of excessive worrying as a primary outcome in the context of clinical trials of youth with generalized anxiety disorder, and as a secondary outcome in trials of CBT for youth with ob
Psychological distress, including depression, anxiety, and stress, requires time-efficient assessment tools suited for digital and momentary settings. The Screening Tool for Psychological Distress (STOP-D) is a five-item scale developed for brief mental health screening, but it has not yet been validated in Swedish. This study aimed to evaluate the psychometric properties and diagnostic accuracy o
Accurate grading of Oil Palm Fresh Fruit Bunches (FFB) is pivotal for maximizing agricultural yield, yet manual assessment in unstructured environments remains labor-intensive and subjective. While Convolutional Neural Networks (CNNs) offer an automated solution, the conventional strategy of scaling network depth often yields diminishing returns or overfitting on moderately sized datasets. To over
Background: Standardized care pathway (SCP) for macrohematuria (patients aged ≥50 years) in Sweden includes four-phase computed tomography urography (CTU) before cystoscopy, but targeted SCP lead time for CTU (6 days)/treatment is fulfilled in <25% of patients. Purpose: To retrospectively analyze the incidence of CTU-diagnosed upper urinary tract (UUT), kidney and bladder tumors, calculi, radiatio
Preconception health status, especially of women, but also of men, is known to influence pregnancy outcomes. Despite knowledge of the growing importance of preconception health, numerous challenges remain for conducting research in this population and delivering appropriate clinical care. The 2023 Global Pregnancy Collaboration annual workshop focused on exploring preconception health as it relate
Objective: In primary health care in southern Sweden, interprofessional medication reviews are conducted, to a limited extent, for patients living independently, with the purpose of optimising their pharmacological treatment. These medication reviews have identified and addressed many important issues regarding the patients’ medication. However, there is limited knowledge regarding the participati
Strut-based structures, such as lattices, produced using additive manufacturing (AM) offer significant potential for applications requiring lightweighting and structural compliance. However, conventional Design for AM (DfAM) approaches often assume idealised material behaviour, which can be misleading for thin strut-based structures where geometric parameters and process-induced effects significan
Disclosed is a method (310) for providing operational feedback during power transfer in a wireless power transfer system. The wireless power transfer system comprises a power transmit device arranged to transfer power over an inductive wireless power transfer interface operating at a transmit frequency to a power receive device. The wireless power transfer system is adapted to transfer information
OBJECTIVES: To identify the lowest sensitivity and specificity that physicians and the general population consider acceptable for medical artificial intelligence (AI), relative to current human performance.METHODS: In a nationwide, cross-sectional survey in Sweden, 2025, random samples of 500 physicians and 500 adults from the general population were mailed a questionnaire presenting three vignett
This study clarifies when Bayesian analysis provides a practical advantage, particularly in large-area searches, hazardous or inaccessible environments, and low signal-to-noise ratio (SNR) scenarios where direct source approach is not feasible. We present a PyMC-based Bayesian framework for localizing a single unshielded gamma-emitting source and estimating its activity, with the ability to switch
Introduction: Cervical cancer represents a significant public health challenge worldwide. To improve screening accessibility and participation, we implemented vaginal human papilloma virus (HPV) self-sampling as part of an organized cervical cancer prevention strategy. This study aimed to evaluate the implementation and outcomes of the self-sampling program in a real-world setting. Material and Me
Accurate prediction of groundwater levels (GWL) is essential for effective and sustainable water resource management, particularly in arid and semiarid regions where excessive extraction and climate change significantly accelerate aquifer depletion. The nonstationary characteristics of groundwater data pose significant challenges to the performance and reliability of conventional machine learning
A high-resolution integrated bio-chemostratigraphic framework is established for the upper Tremadocian to lower Floian (Lower Ordovician) succession of the North China Block, based on new conodont and carbon isotope (δ13Ccarb) data from the Jiguanshan and Wudingshan sections in Liaoning Province, northeastern China. Thirty conodont species of 19 genera were identified from the two sections. Based
IntroductionAnal squamous cell carcinoma (ASCC) is an HPV-related tumor primarily treated with concurrent chemoradiotherapy (CRT). Salvage surgery is reserved for patients with residual or recurrent disease following CRT, representing a highly selected, high-risk subgroup. Population-based data on outcomes and prognostic factors after salvage surgery are limited. This study aimed to assess overall
BACKGROUND: The aim of this study was to examine whether a novel semi-automated dataset based on electronic health record documentation can be used for surveillance of central venous catheter-related mechanical complications (failed catheterisation, bleeding, cardiac arrhythmia, pneumothorax and nerve injury) within 24 hours of catheterisation.METHODS: The semi-automated dataset comprised a fully
OBJECTIVES: Early identification of treatment response in brain metastases remains clinically challenging. This study explores tensor-valued diffusion MRI (dMRI), specifically q-space trajectory imaging (QTI), as a novel source of early imaging biomarkers during stereotactic radiotherapy (SRT).METHODS: Twenty-six patients with brain metastases were enrolled; thirteen met quality and completeness c
Only 40% of the total CO2 emitted by human activities and natural sources remain in the atmosphere, since the rest is taken up by plants and oceans. In particular temperate and boreal forests are usually significant sinks of carbon, even if they are very susceptible ecosystems and they might turn into sources in consequence of the predicted temperature increase. That is one of the reasons why a ne
The exact mechanism of action of IVIg in the amelioration of immune thrombocytopenic purpura (ITP) is still unclear. Studies have suggested that IVIg may function through the regulation of cytokines, including interleukin-1 receptor antagonist (IL-1Ra), an inhibitor of phagocytosis. Using a mouse model relevant to ITP, we confirm an increase in mouse serum levels of IL-1Ra after exposure to IVIg,
Aims: The aim of this study was to test a Child-Centred Health Dialogue model for primary prevention of obesity for 4-year-old children in Child Health Services, for its feasibility and the responsiveness of its outcomes. Methods: A feasibility study was set up with a non-randomised quasi-experimental cluster design comparing usual care with a structured multicomponent Child-Centred Health Dialogu
