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Rates of cognitive decline in Alzheimer’s disease (AD) are extremely heterogeneous. Although biomarkers for amyloid-beta (Aβ) and tau proteins, the hallmark AD pathologies, have improved pathology-based diagnosis, they explain only 20–40% of the variance in AD-related cognitive impairment (CI). To discover novel biomarkers of CI in AD, we performed cerebrospinal fluid (CSF) proteomics on 3,397 ind
BACKGROUND: Counting very low levels of leukocytes is technically challenging but mandatory for quality control of leukocyte-depleted plasma. Established assays, such as flow cytometry and counting in the Nageotte chamber, are laborious and expensive. The aim of this study was to test two alternative assays, the cerebrospinal fluid program in the routine hematology analyzer ADVIA 2120 and a fluore
Introduction: Excessive worry is common during adolescence and across a range of psychiatric conditions. There is a growing evidence base for the efficacy of cognitive behaviour therapy (CBT) in reducing the frequency of excessive worrying as a primary outcome in the context of clinical trials of youth with generalized anxiety disorder, and as a secondary outcome in trials of CBT for youth with ob
Psychological distress, including depression, anxiety, and stress, requires time-efficient assessment tools suited for digital and momentary settings. The Screening Tool for Psychological Distress (STOP-D) is a five-item scale developed for brief mental health screening, but it has not yet been validated in Swedish. This study aimed to evaluate the psychometric properties and diagnostic accuracy o
Accurate grading of Oil Palm Fresh Fruit Bunches (FFB) is pivotal for maximizing agricultural yield, yet manual assessment in unstructured environments remains labor-intensive and subjective. While Convolutional Neural Networks (CNNs) offer an automated solution, the conventional strategy of scaling network depth often yields diminishing returns or overfitting on moderately sized datasets. To over
Background: Standardized care pathway (SCP) for macrohematuria (patients aged ≥50 years) in Sweden includes four-phase computed tomography urography (CTU) before cystoscopy, but targeted SCP lead time for CTU (6 days)/treatment is fulfilled in <25% of patients. Purpose: To retrospectively analyze the incidence of CTU-diagnosed upper urinary tract (UUT), kidney and bladder tumors, calculi, radiatio
Preconception health status, especially of women, but also of men, is known to influence pregnancy outcomes. Despite knowledge of the growing importance of preconception health, numerous challenges remain for conducting research in this population and delivering appropriate clinical care. The 2023 Global Pregnancy Collaboration annual workshop focused on exploring preconception health as it relate
Objective: In primary health care in southern Sweden, interprofessional medication reviews are conducted, to a limited extent, for patients living independently, with the purpose of optimising their pharmacological treatment. These medication reviews have identified and addressed many important issues regarding the patients’ medication. However, there is limited knowledge regarding the participati
Strut-based structures, such as lattices, produced using additive manufacturing (AM) offer significant potential for applications requiring lightweighting and structural compliance. However, conventional Design for AM (DfAM) approaches often assume idealised material behaviour, which can be misleading for thin strut-based structures where geometric parameters and process-induced effects significan
Background: Identifying children with childhood-onset neurodevelopmental problems (NDPs, defined here as autism spectrum disorders [ASDs], attention-deficit/hyperactivity disorder [AD/HD], tic disorders [TDs], learning disorders [LDs] and development coordination disorder), using easily administered screening instruments, is a prerequisite for epidemiological research. Such instruments are also cl
ObjectiveTo investigate the anatomical cure rate and complications related to collagen-coated mesh for cystocele, compared with a conventional anterior colporrhaphy. DesignA randomised controlled study. SettingSix departments of obstetrics and gynaecology in Norway, Sweden, Finland, and Denmark. PopulationWomen aged 55years or older, referred for surgery with a prolapse of the anterior vaginal wal
Excessive worry is common during adolescence and across psychiatric disorders. This study investigates whether: 1) internet-delivered cognitive behavioral therapy (ICBT) focused on exposure to uncertainty is effective in reducing excessive worry; 2) improvements in worry are associated with reductions in other psychiatric symptoms; and 3) changes in intolerance of uncertainty (IU) mediates worry o
The purpose of this work is to identify and analyze the key important barriers to uptake the compressed biogas (CBG) plants in India for enhancing their role as a sustainable energy source. Initially, the barriers are identified from the past academic literature using literature review process and are then validated through the fuzzy Delphi method with expert opinions. The finalized barriers were
Women have always played a central role in smallholder agriculture in many farming systems of the Global South. However, they have had, and still have, low access to agricultural information, and even less ability to enact on training or advice received, in comparison to male farmers. The paper investigates what is needed for female smallholders to better benefit from agricultural advice and train
In several circumstances, a level-three automated vehicle cannot continue driving in an automated driving mode and requests a human driver to take over. In this study, a series of experiments to examine how to provide a TOR was conducted. First, for forty-one persons, a HUD icon, earcon, seat vibration, and combinations were compared. The results indicated that the HUD icon-earcon and HUD icon-sea
Anticancer drugs can be delivered more efficiently to tumor sites with fewer side effects by utilizing magnetic nanoparticles. In this research detailed examinations of the effect of polyethylene glycol (PEG) on microstructure, size distribution, morphology, magnetic performance and coating of cobalt ferrite nanoparticles (CFO) were conducted. CFO nanoparticles were functionalized by PEG under dif
Background: Many patients with a psychotic disorder participate poorly in society. When psychotic disorders are in partial remission, feelings of paranoia, delusions of reference, social anxiety and self-stigmatization often remain at diminished severity and may lead to avoidance of places and people. Virtual reality exposure therapy (VRET) is an evidence-based treatment for several anxiety disord
Background: Patients with generalized social anxiety disorder (SAD) avoid various social situations and can be reluctant to engage in in vivo exposure therapy. Highly personalized practising can be required before patients are ready to perform in vivo exposure. Virtual reality-based therapy could be beneficial for this group.Aims: To assess the feasibility and potential effect of virtual reality-b
Since 1992 the European Union has been granting certificates attesting the veracity and legitimacy of products in all of the EU. Such certificates are a symbol of the importance given by the European Union to the protection of regional products against falsifications of unique foodstuff products and the maintenance of good reputation of rural producers and rural areas. There is, however, a great
Background Sirolimus-coated balloons (SCB) are a potential alternative to paclitaxel-coated balloons (PCB) in the context of percutaneous coronary intervention (PCI). However, comparative data between SCB and PCB remain limited. We aimed to compare the outcome of PCI with contemporary PCB or SCB in a real-world clinical setting. Methods The Swedish Coronary Angiography and Angioplasty Registry (SC
