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Hematopoietic stem cells (HSCs) are of great importance for the body and can be used to treat diseases such as leukemia or autoimmune conditions. To be able to use HSCs more extensively in therapies we need to know more about how they are being regulated, one way to do this is by knocking down genes with RNA interference. In this project we test a new micro RNA (miRNA), called miR30E, to investiga
Fragmentbaserad läkemedelsutveckling (FBDD) har på senare tid utvecklats som en lovande alternativ metod för att identifiera svåråtkomliga bindningsställen, såsom små fickor eller allosteriska säten. Weak affinity chromatography (WAC™) är en FBDD-metod där dissociationskonstanten kan beräknas genom att jämföra retentionstiden på en proteinkolonn med en referenskolonn. Målet med projektet är att möFragment-based drug discovery (FBDD) has in recent years emerged as an interesting method to target challenging binding sites, such as allosteric sites or small pockets. Weak Affinity Chromatography (WAC™) is a FBDD technology where dissociation constants of injected compounds are determined by comparing retention times between a protein column to a reference column. The goal of this project was t
The goal of this research is to investigate how the use of provocative place branding, by companies, influences audience engagement with national identity, from a sensemaking perspective. The study specifically investigates how audiences, in the case of residents of Denmark, make sense of provocative content and how it influences their sense of place and national identity. The answered research qu
Reconfiguring Warehouse Operations at CEPA to Improve Performance:A Design Science Study for Operational Efficiency
Global food systems are increasingly vulnerable to climate change, energy volatility, and geopolitical disruptions—threatening the security and stability of perishable supply chains. This thesis investigates the potential of aseptic packaging technologies, specifically ultra-high-temperature (UHT) treatment and sterile filling, as a means to reduce energy consumption and enhance resilience in the
Översvämningar i urbana miljöer är en växande utmaning i Kigali, Rwanda, särskilt i informella bosättningar där snabb urbanisering och bristfällig infrastruktur ökar risken. Denna studie syftade till att identifiera centrala hinder och drivkrafter som påverkar implementeringen av översvämningsåtgärder inom uppgraderingsprojekt, med särskilt fokus på naturbaserade lösningar (NBS). Genom intervjuer Urban flooding is a growing challenge in Kigali, Rwanda, particularly in informal settlements where rapid urbanisation and inadequate infrastructure increase flood risk. This study aimed to identify key barriers and drivers that influence the implementation of flood risk measures in residential upgrading projects, with a specific emphasis on the potential of nature-based solutions (NBS). Stakehold
This thesis examines how Sweden’s new development policy, Development for a New Era, reconfigures the agency of its civil society organizations (CSOs). The policy marks a major shiftin Sweden’s foreign aid landscape, moving from a human rights– and needs-based approach to one driven by strategic, trade, and migration interests. Drawing on a qualitative analysis of interviews with CSO staff and med
Since the COVID-19 pandemic the need for mental healthcare has increased globally, which has been causing longer waiting times before treatment becomes a possibility. Many new innovations have been made to improve this, such as internet- and artificial intelligence-based treatments. The current study experimented the influence of TalkToAlba platform’s AI-cognitive behavioural therapy chatbot and i
This study presents a custom surface electromyography (sEMG) data acquisition system combining the TI ADS1299 analog-to-digital converter, Teensy MicroMod micro-controller, and a Python-based graphical user interface for real-time signal monitoring and guided data collection. The system outperformed the widely used Ninapro dataset across all major classification metrics, demonstrating improved cla
Steam and water chemistry is fundamental for most power generation on indus trial scale. This includes the dosing of chemicals, the monitoring of both water and steam, as well as understanding the underlying causes to diagnose eventual problems. Öresundsverket, which was designed for seasonal operation, now has to perform multiple starts per year and in meeting these demands there is a possi bilit
This thesis examines how autonomous buses are interpreted and evaluated as a potential mobility solution within a multi-level planning context involving both municipal and regional perspectives. While autonomous vehicles are often framed as a key component of future sustainable transport systems, their implementation depends not only on technological development but also on social acceptance, inst
This thesis aims to address a dual crisis. Globally, the construction industry relies on a linear “take-make-dispose” approach and a “tabula rasa” tactic in each novel project, draining the Earth’s resources. Locally, around a half of residential buildings in Riga, Latvia, are of Soviet mass housing typology. These structures are on the verge of structural expiration, at risk of progressive collap
Solar drying technologies give smallholder farmers in low- to middle-income countries (LMIC) a low-cost way to reduce post-harvest losses and add value to agricultural produce. Yet bringing solar-dried products to market remains poorly understood, particularly in fragmented food systems where structural conditions shape market entry in ways that standard frameworks do not account for. This thesis
Our way of handling the climate crisis is not fast or ambitious enough. We have the opportunity to plan for a better future, not just accept the consequences of our failure. To plan for a better future, we first need to conceptualise a vision of a desired end-point, in this case a climate-neutral and sustainable city. This essay is meant to inspire radical change by using and expanding the radical
This thesis explores experiences of premenstrual syndrome (PMS) and receiving medical treatment for it. Adopting a material-discursive intrapsychic model of thought, the participants' depictions are analyzed through objects, discourses, emotions and internal value systems in order to give various perspectives on PMS as well as contextualize the complex relationship between individual, group, a
Technical drawings play an important role in many industrial processes, including product development, manufacturing, and lifecycle management, by representing the product definition. The purpose of the study was to investigate which processes influence technical drawing creation and management, what challenges are associated with these processes, and how these challenges can be addressed through
This thesis presents the design and schematic-level simulation of a highly linear mixer-first receiver front-end implemented in CMOS, targeting improved robustness against strong input signals. The proposed architecture employs a current-mode passive mixer directly loaded by a low-impedance transimpedance amplifier (TIA) in order to minimize the voltage swing at the mixer output and thereby enhanc
With approximately 94 percent of traffic accidents being caused by human error, improving driver behaviour has the potential to save lives. To encourage safer driving, Volvo Cars is developing a Safety Coach feature for their mobile application. However, pilot studies of a minimum viable product (MVP) indicated low user retention, suggesting the need for design elements that better support user en
This thesis examines how residential buildings from different construction periods perform during extended outages of heating, electricity, and ventilation. The purpose was to evaluate building robustness during crisis or war situations and identify technical measures that may improve building resilience. The study combined literature review with engineering calculations related to heat retention,
