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Popular science summary: Is RpS6 activation important for leukemia cell progression? Acute Myeloid Leukemia (AML) is the most common acute blood cancer in adults. It is characterized by a rapid increase of leukemic cells in the bone marrow, compromising the development of new blood cells. Despite improvement in treatments and advancements in supportive care, the overall 5-years survival of AML i

Improvements in metabolite-profiling techniques are providing increased breadth of coverage of the human metabolome and may highlight biomarkers and pathways in common diseases such as diabetes. Using a metabolomics platform that analyzes intermediary organic acids, purines, pyrimidines, and other compounds, we performed a nested case-control study of 188 individuals who developed diabetes and 188

Objective. The association between smoking and idiopathic inflammatory bowel disease is well known; smoking seems to have a diverse effect. Crohn's disease is associated with smoking, while ulcerative colitis is associated with non-smoking. Data on smoking in microscopic colitis of the collagenous type (CC) are lacking. The aim of this investigation was to study smoking habits in CC and to observe

Tick-borne encephalitis virus (TBEV) causes tick-borne encephalitis (TBE), a severe and sometimes life-threatening disease characterized by viral invasion of the central nervous system with symptoms of neuroinflammation1,2. As with other orthoflaviviruses—enveloped, arthropod-borne RNA viruses—host factors required for TBEV entry remain poorly defined. Here we used a genome-scale CRISPR–Cas9-based

In order to find out whether an interval appendectomy is necessary after an appendicitis with a palpable mass, we retrospectively studied the reports of 50 patients who underwent an interval appendectomy. Out of the 50 patients 5 (10%) developed complications of the appendiceal mass. Intraoperative findings of the interval appendectomy: 32 (64%) had adhesions; 2 (4%) appendices were resorbed; 2 (4

In recent years, scientists have advocated the use of targeted therapies in the form of drugs that modulate genes and proteins that are directly associated with cancer progression and metastasis. Malignant melanoma is a dreadful cancer type that has been associated with the rapid dissemination of primary tumors to multiple sites, including bone, brain, liver and lungs. The discovery that approxima

We prove that unary Sherali-Adams requires proofs of size nΩ(d) to rule out the existence of an nΘ(1)-clique in Erdős-Rényi random graphs whose maximum clique is of size d ≤ 2 log n. This lower bound is tight up to the multiplicative constant in the exponent. We obtain this result by introducing a technique inspired by pseudo-calibration which may be of independent interest. The technique involves

During mammalian ocular development, several signaling pathways control the spatiotemporal highly defined realization of the three-dimensional eye architecture. Given the complexity of these inductive signals, the developing eye is a sensitive organ for several diseases. In this study, we investigated a Dkk1+/- haploinsufficiency during eye development, resulting in coloboma and anterior eye defec

Denna uppsats syftar till att undersöka hur nystartade SME:s ser på nyttjandet av molntjänster och om detta är implementerat i företagens IS strategi. Detta görs med hjälp av en sammanställning av litteratur kopplat till ämnet samt en empirisk datainsamling. Den empiriska datainsamlingen består av sju telefonintervjuer med SME:s. Företagen har valts ur ett urval som är avgränsat till företag som a

In mitosis, most transcription factors detach from chromatin, but some are retained and bookmark genomic sites. Mitotic bookmarking has been implicated in lineage inheritance, pluripotency and reprogramming. However, the biological significance of this mechanism in vivo remains unclear. Here, we address mitotic retention of the hemogenic factors GATA2, GFI1B and FOS during haematopoietic specifica

This paper presents analyses on the trends of IS curriculum development that has evolved since its inception from the classical report by the AIS/ACM task force led by Heikki Topi and colleagues published in 2010. Based on an integrated synthesis of the literature, we categorize it into three theoretically-driven dimensions: (i) IS Curricula; (ii) Topic-Based IS Curricula, and (iii) IS Identity Cr

We prove that for k ≫; 4√n regular resolution requires length nω(k) to establish that an ErdÅ's-Rényi graph with appropriately chosen edge density does not contain a k-clique. This lower bound is optimal up to the multiplicative constant in the exponent and also implies unconditional nω(k) lower bounds on running time for several state-of-the-art algorithms for finding maximum cliques in graphs.

We prove that for k ≪ 4 n regular resolution requires length nΩ(k) to establish that an Erdős–Rényi graph with appropriately chosen edge density does not contain a k-clique. This lower bound is optimal up to the multiplicative constant in the exponent, and also implies unconditional nΩ(k) lower bounds on running time for several state-of-the-art algorithms for finding maximum cliques in graphs.

There is (or should be) an archived specimen, a reference copy if you like, for all living and fossil species that have been described scientifically. These physical specimens, so-called name-bearing type specimens, are housed at museums or academic institutes around the world for researchers to study and perhaps compare with their own material. But what about our own species, Homo sapiens?.