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BackgroundLongitudinal data on weight change, its timing, and the age of obesity onset in relation to cause-specific mortality are limited.MethodsFrom ODDS, a nationwide pooled cohort study in Sweden, we included 258,269 men and 361,784 women with at least three weight assessments between ages 17 and 60, collected in 1963–2015. We applied linear mixed-effects models to estimate weight trajectories
Parallel import in the European Union is the perfectly legal activity under Art. 28-30 EC of buying goods in a low-price country in order to ship and sell them in a high-price country. The pharmaceutical market in Europe is subject to the subsidiartiy principle of Art. 5 EC and heavily characterised by national regulations that lead to significant price differentials between – generally speaking –
Widespread presence of toxic and persistent pollutants in the environment, even at low concentrations, causes risks of adverse effects to human health and the ecosystem. Biological methods for treatment of water streams and removal of persistent pollutants are of great interest due to their simplicity, low cost, and mild operational conditions without harmful by-products. The purpose of this resea
Background Despite high incidence of ankle fractures in the elderly, studies evaluating outcome and impact of quality of life in this age group specifically are sparse. The aim of this study was to evaluate outcome and quality of life 6 and 12 months after injury in patients 65 years or older who had been operated on due to an ankle fracture. Methods Sixty patients 65 years or older were invited
OBJECTIVE: Neutrophil deposition in tissues (leukosequestration) after shock may produce local tissue injury from proteases and high-energy oxygen species released from sequestered neutrophils. The initial step in the binding of neutrophils to capillary endothelium is the interaction of adhesion molecule (selectin) receptors between neutrophils and endothelial cells. We quantified leukosequestrati
CS 22949-037 is one of the most metal-poor giants known ([Fe/H]~-4.0),and it exhibits large overabundances of carbon and nitrogen (Norris etal.). Using VLT-UVES spectra of unprecedented quality, regardingresolution and S/N ratio, covering a wide wavelength range (from lambda= 350 to 900 nm), we have determined abundances for 21 elements in thisstar over a wide range of atomic mass. The major new d
Popular Abstract in Swedish Talet om det mångkulturella i skolan och samhället: En analys av diskurser om det mångkulturella inom utbildning och politik åren 1973-2006 Det svenska samhället har under de senaste tre decennierna påverkats av debatter, rapporteringar och diskussioner om det mångkulturella samhället. Frågan om hur man ska handskas med ?det mångkulturella? har uppfattats och beskrivitThe debate on "multicultural issues" has had a considerable impact on society, and in Sweden, dealing with such issues has been described and defined as a major problem. The aim of the present thesis is to analyse the various contents of discourses on multicultural issues that have influenced education and policy documents during the period 1973-2006. On several occasions, the Swedish government h
Popular Abstract in Swedish HIV är en av de dödligaste farsoterna i världen och 30-40 miljoner människor beräknas ha dött AIDS. Genom att konstant förändra sig ligger viruset hela tiden ett steg före immunförsvaret, och immunförsvaret klarar därför inte av att bekämpa infektionen. HIV skiljer sig också från andra virus genom att det drabbar och långsamt utplånar immunförsvaret. Det gör att HIV kanThe two genetically related human lentiviruses known today, HIV-1 (which is pandemic) and HIV-2 (which mainly is confined to West Africa), are the causative agents of AIDS. Progressive immune dysfunction and AIDS develop in most cases of untreated HIV-1 infection, but only in approximately 25-30% of HIV-2 infected individuals. The V1-V3 region of the HIV-1 env gp120 is important for HIV-1 corecept
Popular Abstract in Swedish Stroke, eller slaganfall, är en sammanfattande benämning på sjukdomar som drabbar blodförsörjningen i hjärnan. Varje år insjuknar cirka 30000 personer i Sverige i stroke, av dessa drabbas cirka 15% av blödningar medan resterande 85% får infarkter, dvs blodpropp i hjärnan. Stroke upptar fler vårddagar i slutenvården än någon annan somatisk sjukdom. Medianåldern för insjuBackground Stroke is a serious vascular disorder that comprises intracerebral hemorrhages, subarachnoid hemorrhages and ischemic stroke (IS). The etiology of stroke, including hereditary components induced by cellular mechanisms, is therefore a research field of vital importance. The aim of this thesis was to assess possible genetic impact on stroke risk. We thus evaluated family history of strok
Heart failure (HF) is a morbid and heritable disorder for which the biological mechanisms are incompletely understood. We therefore examined genetic associations with HF in a large national biobank, and assessed whether refined phenotypic classification would facilitate genetic discovery. Methods: We defined all-cause HF among 488 010 parti
Stress, Unmanageability, FOMO, and Lack of Recovery: A New Perspective on Adolescent Mental HealthToday, many of the challenges that adolescents face involve mental health issues, some of which have the potential of negatively affecting them for a long time to come. There is, however, at present a lack of a detailed account on the mental health issues experienced by adolescents in Sweden. This stu
Importance: Low academic achievement (AA) in childhood and adolescence is associated with increased substance use. Empirical evidence, using longitudinal epidemiologic data, may provide support for interventions to improve AA as a means to reduce risk of drug abuse (DA). Objective: To clarify the nature of the association between adolescent AA and risk of DA by using instrumental variable and co-r
Importance: Disrupted sleep commonly occurs with progressing neurodegenerative disease. Large, well-characterized neuroimaging studies of cognitively unimpaired adults are warranted to clarify the magnitude and onset of the association between sleep and emerging β-amyloid (Aβ) pathology. Objective: To evaluate the associations between daytime and nighttime sleep duration with regional Aβ pathology
Aims/hypothesis: Data analyses from Swedish individuals with newly diagnosed diabetes have suggested that diabetes could be classified into five subtypes that differ with respect to the progression of dysglycaemia and the incidence of diabetes consequences. We assessed this classification in a multiethnic cohort of participants with established and newly diagnosed diabetes, randomly allocated to i
Popular Abstract in Swedish Förmaksflimmer är den vanligaste rytmrubbningen i hjärtat som kräver behandling. Risken att drabbas ökar med åldern och 8% av alla åttioåringar lider av förmaksflimmer. Förmaksflimmer är i sig inte livshotande, men den förhöjda risken för proppbildning i förmaken kan leda till allvarliga komplikationer såsom stroke. Det finns olika behandlingsstrategier för förmaksflimmThis thesis deals with signal processing algorithms for analysis of the electrocardiogram (ECG) during atrial fibrillation (AF). Such analysis can be used for diagnosing patients, and for monitoring and predicting their response to various treatment. The thesis comprises an introduction and five papers describing methods for ECG-based modeling and characterization of AF. Paper I--IV deal with meth
Popular Abstract in Swedish Avhandlingen innehåller fyra artiklar som berör olika aspekter av offentlig omfördelning i välfärdsstaten. Avhandlingen syftar till att ge kunskap om konsekvenser av, motiv för och mätande av och denna omfördelning. Den första artikeln ställer frågan: Hög hög skatteomfördelning från arbetande till icke arbetande kan motiveras av grundantagandet att naturresurser är gemThis thesis is an attempt to generate knowledge about the justification, measurement and consequences of public redistribution. The first paper poses the following question: How much redistribution from working to non-working can be justified by arguing that external resources are owned jointly by all, or that ownership should ideally be divided equally? This question is analyzed using bargaining
STUDY QUESTION: Does previous bariatric surgery (BS) in women affect cumulative live birth rate in IVF?SUMMARY ANSWER: Women having had BS seem to have the same cumulative live birth rate as non-operated women of the same BMI at IVF treatment.WHAT IS KNOWN ALREADY: Because of the perinatal risks of obesity to mother and infant as well as impaired outcomes of IVF, obese women are advised to reduce
Popular Abstract in Swedish Med snabbare och pålitligare analysresultat finns stora möjligheter till ett ökat utnyttjande av avfallsresurser för produktion av förnybar energi. Resultat från min forskning gör det möjligt att analysera råvaror för biogasproduktion med större säkerhet och med möjligheten att få upp till nio gånger snabbare resultat. Produktion av biogas har under den senaste tiden öA sustainable treatment of organic wastes, generation of renewable energy, reduction of green house gas emissions, limiting the eutrophication and closing the nutrient cycles are several environmental challenges for which anaerobic digestion may be a suitable solution. There is today a large amount of available organic waste materials that could serve as potential feedstock for biogas production.
IMPORTANCE: Recent studies suggest standard reference intervals for serum free light chains (FLC) are inaccurate and that this problem can only be partially remedied by using separate reference intervals for individuals with impaired kidney function. This decreases the utility of FLC testing in the clinical evaluation and follow-up of plasma cell disorders, particularly affecting the diagnosis of
When humans are involved, things can go wrong. This is a statement as factually true and yet dramatically undefined and dangerously ambiguous as any. No matter the industry or domain, where humans interact with other humans, perfect predictability is impossible and a focus on negative outcomes can seem natural. When outcomes are anything less than ideal and when these events and outcomes are made
