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IL-10 is a pleiotropic cytokine with stimulatory and inhibitory properties, and is thought to have a protective role in rheumatoid arthritis and collagen-induced arthritis (CIA). In this study, we investigated how IL-10 deficiency affects CIA and anti-collagen type II (CII) Ab-transferred arthritis in C57BL/10.Q (B10.Q) mice. The B10.Q.IL-10(-/-) mice had an 8-cM 129/Ola fragment around the IL-10
Objective. To investigate whether measurements of proinsulin and/or intermediate proinsulin degradation products could be used to differentiate between autoimmune (type 1) and non-autoimmune (type 2) diabetes in young adults. Material and methods. Total proinsulin, intact proinsulin and 32,33 split proinsulin concentrations were measured in 25 patients aged 15-34 years with type 1 diabetes, as def
This study investigates the mechanisms of (de)coding modality, focusing on the interpretation of utterances containing the modals must, may, måste, and kan. The main research question posed in this study is what enables the interlocutors to interpret modal expressions so that communicative goals are achieved. To answer this general question, Coates's (1983) study on modal contexts is initially rep
Increased nitrogen leaching from forest soils is a potential environmental problem in areas with high nitrogen deposition. In Sweden nitrogen is strongly retained in the forests, and high nitrogen leaching is not common from growing forests. However, soil water measurements on clearcuts along a deposition gradient in Sweden showed a positive correlation between increased concentration of inorganic
Popular Abstract in Swedish Utbredningen av besvär som attribueras till elektrisk utrustning respektive kemikalielukter och andra odörer är ännu ej till fullo fastställd. Vidare saknas kunskap om eventuella bakomliggande faktorer för dessa besvärs uppkomst. Syftet med avhandlingen var att undersöka utbredningen av besvär som attribueras till elektriska faktorer, kemikalier och lukter, samt undersSelf-reported annoyance from electrical equipment has been in evidence since the mid-eighties, and the first reports of illness from everyday chemicals arose already in the 1960?s. However, the extent of the problem or the mechanisms behind the development of environmentally related annoyance has not yet been fully established. Increased vulnerability to stress has been suggested to be a possible
The aims of this study were to investigate if low-frequency fatigue (LFF) dependent on the duration of repeated muscle contractions and to compare LFF in voluntary and electrically induced exercise. Male subjects performed three 9-min periods of repeated isometric knee extensions at 40% maximal voluntary contraction with contraction plus relaxation periods of 30 plus 60 s, 15 plus 30 s and 5 plus
The cone snail is the only invertebrate system in which the vitamin K-dependent carboxylase (or gamma-carboxylase) and its product gamma-carboxyglutamic acid (Gla) have been identified. It remains the sole source of structural information of invertebrate gamma-carboxylase substrates. Four novel Gla-containing peptides were purified from the venom of Conus textile and characterized using biochemica
Silver birch and common oak are known to be sensitive to standard practices in nurseries and they often show poor establishment when transplanted in urban areas. Lifting date and time in cold storage have a strong influence on stress tolerance and plant vitality. This study was carried out to assess the effect of lifting date and storage time on partial photosynthesis measured by chlorophyll fluor
The aim of the present study was to analyse quantitatively, on a cat gastrocnemius preparation in vivo, the effects of i.a. or i.v. administered glyceryl trinitrate (GTN), sodium nitroprusside (SNP) or nitric oxide (NO dissolved in saline) on vascular resistance (tone) in the following consecutive vascular sections: Large-bore arterial resistance vessels (> 25 microns), small arterioles (< 25 micr
alpha-Cells were identified in preparations of dispersed mouse islets by immunofluorescence microscopy. A high fraction of alpha-cells correlated with a small cell size measured as the average cell diameter (10 microm) and whole-cell capacitance (<4 pF). The alpha-cells generated action potentials at a low frequency (1 Hz) in the absence of glucose. These action potentials were reversibly inhibite
We used site-directed mutagenesis to alter the specificity of human cystatin C, an inhibitor with a broad reactivity against cysteine proteinases. Nine cystatin C variants containing amino acid substitutions in the N-terminal (L9W, V10W, V10F and V10R) and/or the C-terminal (W106G) enzyme-binding regions were designed and produced in Escherichia coli. It was discovered that the inhibition profile
Objective: Pain measurement is a necessity in pain treatment but can be difficult in young children. The aim of this study was to evaluate the validity and reliability of the Behavioural Observational Pain Scale (BOPS) as a postoperative pain measurement scale for children aged 1-7 yrs. The scale assesses three elements of pain behaviors: facial expression, verbalization, and body position. Design
Popular Abstract in Swedish Avhandlingen behandlar olika aspekter av produktivitet och ekonomisk tillväxt i Afrika och består av fyra kapitel. I det första kapitlet utförs en analys av de faktorer som påverkar Afrikas tillväxt på lång sikt. Analysen är baserad på en studie av ett antal Afrikanska länder som genomgått stark ekonomisk tillväxt under längre perioder. Studiens främsta slutsatser är atThe thesis comprises an introductory chapter and four research papers. The introductory chapter provides a brief overview of recent economic growth performance in Africa, places the individual papers into a coherent context, summarizes the main findings, and discusses their relevance for economic policy. The first paper, The Role of Capital Accumulation, Adjustment and Structural Change for Take-
Triglycerides and phospholipids in human liver material obtained by fine-needle aspiration biopsy have been determined according to an improved version of a previously developed method. The molar ratios of these lipids have been compared with the same ratios determined on material representing whole liver. The average value of the ratios in the fine-needle specimens was 101% (83-113%) of the corre
Popular Abstract in Swedish Människans utveckling och fysiologiska anpassning till upprätt kroppställning är beroende av en rad blodtrycksreglerande mekanismer. Vid ortostatisk hypotension sjunker blodtrycket i samband med uppresning från liggande till stående. Detta beror på en sviktande cirkulationsanpassning så att organismen inte förmår att upprätthålla ett tillräckligt högt blodtryck. SymtomeOrthostatic hypotension (OH) is believed to be an important cause of cerebral hypoperfusion, leading to chronic fatigue, blurred vision, unsteadiness, dizziness and sometimes syncope. It may also result in episodes of confusion, falls and fractures. The coupling between OH and organic dementia is not clear. Our findings in a large group of patients with Alzheimer's disease, vascular- and frontotem
Popular Abstract in Swedish I denna studie har de grundläggande aspekterna på mass- och värmetransport i membrantekniken pervaporation studerats. Speciell tonvikt har lagts vid pervaporations användbarhet i samband med aromämnesåtervinning. Masstransporten i pervaporation påverkas av ett yttre masstransport- motstånd kallat koncentrationpolarisation. Detta fenomen kan orsaka att fluxen av de seleIn this study, the fundamental mass and heat transfer properties of the membrane separation process called pervaporation were investigated. The suitability of pervaporation for aroma compound recovery was especially evaluated. The mass transfer in pervaporation is affected by an external mass transfer resistance in the liquid feed boundary layer, i.e. the concentration polarization phenomenon. Th
Mira is the perfect purity where the demonic of the master mason has no access. The craftsman’s wife is the embodiment of innocence, the heavenly depiction of mankind as opposed to demonic Manole. “Serenity” and “light” are words that repeatedly occur in her monologue thus suggesting the plenitudine of being she is about to conceive when she would be raising into the light her perfect precious, th
We investigated how the legacy of warming and summer-drought affected microbial communities in five different replicated long-term (>10 years) field-experiments across Europe (EU-FP7 INCREASE infrastructure). To focus explicitly on legacy effects (i.e. indirect rather than direct effects of the environmental factors), we measured microbial variables under the same moisture and temperature in a bri
A 2.0-million-year-old shallow-submarine sedimentary deposit on Milos Island, Greece, harbours an unmetamorphosed fossiliferous iron formation (IF) comparable to Precambrian banded iron formations (BIFs). This Milos IF holds the potential to provide clues to the origin of Precambrian BIFs, relative to biotic and abiotic processes. Here, we combine field stratigraphic observations, stable isotopes
