Filtyp
Paleomagnetic data, although undeniably limited, have been used to constrain complex time-varying geomagnetic field models. Here we present four different versions of a time varying geocentric dipole model for the past approximately 9000 years based on a limited selection of sedimentary paleomagnetic data with good spatial coverage. The robustness of the modeling approach is evaluated using modern
An observational study, focusing on motorcyclists, was conducted between June and August 2012 at access points on straight road sections of primary roads in Malaysia. This was done in order to gain more insight into the actual road traffic situation at these sites. The majority of the motorcyclists kept to the speed limit and lowered speed when approaching an access point, especially when road use
Purpose: Commercial EPIDs are normally used in indirect detection mode (iEPID) where incident x-ray photons are converted to optical photons in a phosphor scintillator, which are then detected by a photodiode array. The EPIDs are constructed from a number of nonwater equivalent materials which affect the dose response of the detector. The so-called direct detection EPIDs (dEPIDs), operating withou
Regional, national and global cities are disproportionately located on small islands and archipelagos. The spatial turn' within island and urban geography increasingly privileges abstract notions of space, yet the prevalence of big cities on small islands suggests that sensitivity to place-specific spatial factors is necessary if we are to understand both islands and the urban. Whereas previous st
The ability to reliably estimate CO2 fluxes from current in situ atmospheric CO2 measurements and future satellite CO2 measurements is dependent on transport model performance at synoptic and shorter timescales. The TransCom continuous experiment was designed to evaluate the performance of forward transport model simulations at hourly, daily, and synoptic timescales, and we focus on the latter two
Key stereoelectronic properties of Desulfovibrio desulfuricans [FeFe]-hydrogenase (DdH) were investigated by quantum mechanical description of its complete inorganic core, which includes a Fe6S6 active site (the H-cluster), as well as two ancillary Fe4S4 assemblies (the F and F' clusters). The partially oxidized, active-ready form of DdH is able to efficiently bind dihydrogen, thus starting H-2 ox
Internationally comparable quality assurance of Human Papillomavirus (HPV) DNA detection and typing methods is essential for evaluation of HPV vaccines and effective monitoring and implementation of HPV vaccination programs. Therefore, the World Health Organisation (WHO) HPV Laboratory Network (LabNet) designed an international proficiency study. Following announcement at the WHO website, respondi
Objective: The objective of this study was to assess the level of agreement between stroke subtype classifications made using the Trial of Org 10172 Acute Stroke Treatment (TOAST) and Causative Classification of Stroke (CCS) systems. Methods: Study subjects included 13,596 adult men and women accrued from 20 US and European genetic research centers participating in the National Institute of Neurol
The nitrate reductase activity (NRA) was measured during spring, early summer and late summer in three deciduous forests, where the tree layer was dominated by oak. The nitrate assimilation capacities of the compartments of the above-ground and below-ground biomass of the understory and of the leaves and roots of the tree layer were calculated as NRA per unit biomass and NRA per unit area. The NRA
The laminate flooring company Pergo (Europe) AB has during the last years identified an increasing market demand for customized flooring solutions. In the autumn of 2004 Pergo had no standardized product offer and the existing administrative process was not suited to produce and deliver customized products. Experiments concerning a new décor production technique with extensive potential based on d
BACKGROUND: Circulating human osteocalcin (hOC) has been used as a marker of bone formation. Our aim was to validate three immunofluorometric assays (IFMAs), measuring different forms of hOC. METHODS: The two-site IFMAs were based on previously characterized monoclonal antibodies. Assay 2 recognized intact hOC, assays 4 and 9 measured the NH(2)-terminal mid-fragment and the intact hOC. In addition
Dodecin from Halobacterium salinarum is a dodecameric, hollow-spherical protein, which unspecifically adopts flavin molecules. Reduction of flavin dodecin holocomplexes induces dissociation into apododecin and free flavin. Unspecific binding and dissociation upon reduction were used as key properties to construct an electrochemically switchable surface, which was able to bind and release dodecin a
Anti-citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis (RA) and represent an important tool for the serological diagnosis of RA. In this study, we describe ACPA reactivity to overlapping citrullinated Epstein-Barr virus nuclear antigen-1 (EBNA-1)-derived peptides and analyze their potential as substrates for ACPA detection by streptavidin capture enzyme-linked immunos
Numerous methods for predicting c-turns in proteins have been developed. However, the results they generally provided are not very good, with a Matthews correlation coefficient (MCC) ≤0.18. Here, an attempt has been made to develop a method to improve the accuracy of γ-turn prediction. First, we employ the geometric mean metric as optimal criterion to evaluate the performance of support vector mac
This text deals with the analysis of the removal of the monument to Soviet Marshal Ivan Konev from the Prague 6 district, an important part of the capital of the Czech Republic. The given monument was built during the Soviet occupation of Czechoslovakia in 1980 and removed in 2020. The primary reason for the removal was the dissatisfaction of the political representation of Prague 6 and the leader
Dihydropyrimidinase (DHPase) is a key enzyme in the pyrimidine pathway, the catabolic route for synthesis of β-amino acids. It catalyses the reversible conversion of 5,6-dihydrouracil (DHU) or 5,6-dihydrothymine (DHT) to the corresponding N-carbamoyl-β-amino acids. This enzyme has the potential to be used as a tool in the production of β-amino acids. Here, the reaction mechanism and origin of ster
Reliable quantitative vegetation reconstructions for Europe during the Holocene are crucial to improving our understanding of landscape dynamics, making it possible to assess the past effects of environmental variables and land-use change on ecosystems and biodiversity, and mitigating their effects in the future. We present here the most spatially extensive and temporally continuous pollen-based r
Histopathological diagnosis of pulmonary tumors is essential for treatment decisions. The distinction between primary lung adenocarcinoma and pulmonary metastasis from the gastrointestinal (GI) tract may be difficult. Therefore, we compared the diagnostic value of several immunohistochemical markers in pulmonary tumors. Tissue microarrays from 629 resected primary lung cancers and 422 resected pul
Increased incidence of squamous cell carcinoma (SCC) of the tongue has been reported in young adults (YA) in several countries since the 1980s and confirmed in later studies. The etiology is unclear, the prognosis has been debated, and conflicting results have been published. Some studies show better survival in young adults than in older patients, some worse, and others no difference. Most studie
