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Luminescent properties of KTb(MoO4)2 and K5Tb(MoO4)4 crystals, possessing the same elemental composition but different crystal structures, were studied. The structural arrangement of Tb3+ ions, ordered in KTb(MoO4)2 and disordered in K5Tb(MoO4)4, determines their luminescence properties. Partial lattice disorder of K5Tb(MoO4)4 results in broadened bands of Tb3+ emission and excitation spectra, but
Galectins are a family of carbohydrate-recognising proteins involved in regulation of cell adhesion and cell signaling, leading to roles in e.g. cancer progression, fibrosis, and ulcerative colitis. Glycomimetic galectin inhibitors based on different molecular scaffolds are known and have demonstrated effects from cell experiments to the clinic. Presented here is the synthesis and evaluation of 3-
Translation-targeting toxic small alarmone synthetases (toxSAS) are effectors of bacterial toxin-antitoxin systems that pyrophosphorylate the 3'-CCA end of transfer RNA (tRNA) to prevent aminoacylation. toxSAS are implicated in antiphage immunity: Phage detection triggers the toxSAS activity to shut down viral production. We show that the toxSAS FaRel2 inspects the tRNA acceptor stem to specifical
In the aftermath of the Covid-19 pandemic, the accelerated shift to remote and hybrid work modes has left many office buildings vacant. Meanwhile, many cities struggle with providing housing. Adaptive reuse (AR) is the process of giving an existing building a new life, typically through an extensive renovation and refurbishment. Residential adaptative reuse specifically refers to adapting for hous
The aim of this study was to give insights on the effects of an industrially relevant kilning method, with a focus on lipase inactivation and oat-base production. Storage of non-kilned, dehulled oat kernels in either room temperature or at 37 °C for up to 64 days led to increasing lipase activity with time, despite a decrease in moisture content and water activity, demonstrating the importance of
The diffusion of macromolecules, nanoparticles, viruses, and bacteria is essential for targeting hosts or cellular destinations. While these entities can bind to receptors and ligands on host surfaces, the impact of multiple binding sites—referred to as multivalency—on diffusion along strands or surfaces is poorly understood. Through numerical simulations, we have discovered a significant accelera
The mismatch of the coefficients of thermal expansion between cathode and electrolyte is one of the thorniest problems for high-performance proton-conducting solid oxide fuel cells (H–SOFCs). Here one strategy is applied by introducing the negative thermal expansion component, Y2Mo3O12 (YMO), on Ba0.5Sr0.5Co0.8Fe0.2O3-δ (BSCF) cathode to overcome this difficulty. As a result, not only the electrol
The Storage Location Assignment Problem (SLAP) has a significant impact on the efficiency of warehouse operations. We propose a multi-phase optimizer for the SLAP, where the quality of an assignment is based on distance estimates of future-forecasted order-picking. Candidate assignments are first sampled using a Markov Chain accept/reject method. Order-picking Traveling Salesman Problems (TSPs) ar
The main protease Mpro, nsp5, of SARS-CoV-2 (SCoV2) is one of its most attractive drug targets. Here, we report primary screening data using nuclear magnetic resonance spectroscopy (NMR) of four different libraries and detailed follow-up synthesis on the promising uracil-containing fragment Z604 derived from these libraries. Z604 shows time-dependent binding. Its inhibitory effect is sensitive to
This study aims to broaden our historical knowledge about ideas of rationalism and monocultures in forestry science and rational forest management. Empirically, it focuses on the writings of Swedish forestry scientist Henrik Hesselman, active in the early twentieth century. The texts were analyzed using the method of historical contextualization. The study indicates that monocultures historically
Despite the long tradition of fieldwork and qualitative research practice in tourism studies, the reporting of methodological notes and reflections is limited in the literature. Many excellent methodological remarks in research reports and graduate theses find few outlets in academic journals and those few contributions that are eventually published often emphasize the novelty of the method rather
Carbon monoxide (CO) is an odorless and colorless gas with multiple sources that include engine exhaust, faulty furnaces, and other sources of incomplete combustion of carbon compounds such as house fires. The most serious complications for survivors of consequential CO exposure are persistent neurological sequelae occurring in up to 50% of patients. CO inhibits mitochondrial respiration by specif
In many civil engineering problems, soil is stabilized by a combination of binders and water. The success of stabilization is evaluated using seismic tests with measured P-wave velocities. Optimization of process, laboratory testing and data modelling are essential to reduce the costs of the industrial projects. This paper reports the optimized workflow of soil stabilization through evaluated effe
Postural orthostatic tachycardia syndrome (POTS) occurs in approximately 30% of people with highly symptomatic post-COVID-19 condition (PCC). It involves several symptoms that limit physical and psychological functions and cause reduced quality of life. Evidence for different treatments of POTS and PCC is limited, and this study aimed to evaluate the feasibility of individually tailored physical e
BACKGROUND: Beneficial effects from practising a Paleolithic diet as compared to a diabetes diet on weight, waist circumference, satiety, leptin, HbA1c and glucose control in randomised controlled trial participants with type 2 diabetes could be due to lower leptin resistance. Support for this hypothesis comes from an in vitro experiment that showed that digested wheat gluten, which is excluded fr
Antibunching effect is typically observed in individual systems possessing photoluminescence (PL) blinking and vice versa. Contrary to this common perception, absence of antibunching in strongly blinking methyl ammonium led tri-iodide (MAPbI3) perovskite crystals of sizes from tens to hundreds of nanometers regardless of the excitation power density is observed. Antibunching effect does not appear
Introduction: The metabolic syndrome (MetS) is an adverse metabolic state composed of obesity, hyperglycemia/pre-diabetes, hypertension, and dyslipidemia. It substantially increases the risk of type 2 diabetes, cardiovascular disease (CVD) and mortality, and has a huge impact on public health. Area covered: The present review gives an update on the definition and prevalence of MetS, and its impact
In connection to an environmental investigation of a former industrial site, the cretaceous sandy limestone bedrock in the surrounding area were mapped with resistivity and time domain induced polarization (DCIP). The aim of the DCIP survey was to delineate geological units and possible preferential pathways of DNAPL contaminated groundwater. Although IP anomalies corresponding to fractured crysta
