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Objectives: This study aimed to investigate how the use and perceived unmet need of mobility devices (MD) in people with Parkinson's disease (PD) evolve over a 3-year period. Methods: The study reports baseline assessments (n = 255) and comparisons for participants with complete data at baseline and the 3-year follow-up (n = 165). Structured questions addressed the use and perceived unmet need of
The objective in this research has been to predict the current and future moisture and temperature distribution in a concrete reactor containment, RC. The overall objective in this project was to create a model to be able to predict the moisture and temperature distribution in the concrete wall of the RC of a Pressurized Water Reactor, PWR. In addition, one objective was to design a model to simul
Introduction: The central question this study sought to answer was whether the team members of Strategic Crisis Teams (SCTs) participating in mass-casualty incident (MCI) exercises in the Netherlands learn from their participation. Methods: Evaluation reports of exercises that took place at two different times were collected and analyzed against a theoretical model with several dimensions, looking
Background: Post-hepatectomy liver failure (PHLF) is considered a main reason for death after major hepatectomy. The reported PHLF-related mortality differs largely and the data mainly originate from single centers. Aim: A retrospective, population-based register study was designed to evaluate the impact of PHLF on 90-day mortality after hepatectomy. Method: All patients who underwent liver resect
Secondary organic aerosol (SOA) mass yields were tested for six combinations of two anthropogenic volatile organic compounds (AVOC); m-xylene & toluene, and three biogenic volatile organic compounds (BVOC); α-pinene, myrcene & isoprene. The purpose was to investigate any non-additive results in SOA formation from mixtures of AVOCs and BVOCs by comparing experimental yield with correspondin
Background: Repetitive elements, particularly satellite DNA (satDNA), play a significant role in genome evolution and organisation. However, their diversity and evolutionary dynamics remain poorly understood in non-model organisms. Freshwater crayfish (Decapoda, Astacidea) have large genomes with a high chromosome number and are rich in satDNAs. This makes them attractive for studying the impact o
In this licentiate thesis the implications of a deliberate use of logistics knowledge have been investigated by describing and analyzing the use of a supply chain management approach in the construction industry.
A five-step approach is used in the thesis. First, theoretical models are developed from the supply chain management literature. Two models are elaborated; One model identifying sup
Lactobacillus reuteri metabolizes glycerol through propanediol-utilization (Pdu) pathway to 1,3-propanediol (1,3-PD) via 3-hydroxypropionaldehyde (3-HPA) as intermediate. In the resting cells, the oxidized co-factor obtained in the reaction is regenerated by simultaneous oxidation of 3-HPA to 3-hydroxypropionic acid (3-HP) using propionaldehyde dehydrogenase (PduP), phosphotransacylase (PduL) and
The inherent limitations of a specific pencil beam model have been studied when applied to a cylindrical geometry simulating the neck region. A comparison is made between measured and calculated absorbed dose in a cylindrical phantom. The goal is to quantify the deviations in the absorbed dose level, i.e., the dose per monitor unit, when photons are used for the treatment of head and neck tumours.
Background Impaired activation of the human skeletal muscle glycogen synthase by insulin is typical for type 2 diabetic patients. Regulation of glycogen synthase occurs mainly by phosphorylation/dephoshorylation but little is known whether there also is transcriptional regulation. Therefore we studied transcriptional regulation of the human skeletal muscle glycogen synthase gene (GYS1) and evaluat
AIMS/HYPOTHESIS: Glucose-stimulated insulin secretion is dependent on the electrical activity of beta cells; hence, genes encoding beta cell ion channels are potential candidate genes for type 2 diabetes. The gene encoding the voltage-dependent Ca(2+) channel Ca(V)2.3 (CACNA1E), telomeric to a region that has shown suggestive linkage to type 2 diabetes (1q21-q25), has been ascribed a role for seco
The climate impact of new cars in Sweden 2009 has been evaluated by the Swedish Transport Administration. Their report takes into account reduction factors to attribute the positive impact of renewable fuels on CO2 emissions. The Swedish Transport Administration recommends the public to buy cars that can run on biofuels. Besides acknowledging prevailing uncertainties for many of the input paramete
As digital photography is being increasingly used in clinical medicine, we devised a software program for 'on screen' image analysis, which allows distance, angle, and area to be measured. In this study, 30 photos were evaluated by 10 observers, so 3000 observations were used to test the reproducibility of the measurements. The results showed excellent reproducibility within observer, between obse
High hyperdiploid (51-67 chromosomes) acute lymphoblastic leukemia (ALL) is one of the most common childhood malignancies, comprising 30% of all pediatric B cell-precursor ALL. Its characteristic genetic feature is the nonrandom gain of chromosomes X, 4, 6, 10, 14, 17, 18 and 21, with individual trisomies or tetrasomies being seen in over 75% of cases, but the pathogenesis remains poorly understoo
The anticoagulant vitamin K-dependent protein S (PS) circulates in plasma in two forms, 30% free and 70% being bound to the complement regulatory protein C4b-binding protein (C4BP). The major C4BP isoform consists of 7 alpha-chains and 1 beta-chain (C4BP beta(+)), the chains being linked by disulfide bridges. PS binds to the beta-chain with high affinity. In plasma, PS is in molar excess over C4BP
Microdialysis was used to study how ischemia-evoked gastric mucosal injury affects rat stomach histamine, which resides in enterochromaffin-like (ECL) cells and mast cells. A microdialysis probe was inserted into the gastric submucosa, and the celiac artery was clamped (30 min), followed by removal of the clamp. Microdialysate histamine was determined by enzyme-linked immunosorbent assay. In addit
The objective of this paper is to investigate how the combustion chamber design will influence combustion parameters and emissions in a natural gas SI engine. Ten different geometries were tried on a converted Volvo TD102 engine. For the different combustion chambers emissions and the pressure in the cylinder have been measured. The pressure in the cylinder was then used in a one-zone heat-releas
A novel immunoassay (PINC-ELISA) was designed using proteinase inhibitors of the cystatin superfamily (PINC) in the solid phase, to promote the selective capture of cysteine proteinases. The method was applied in the identification of papain-like antigens from parasitic protozoa. PINC of human origin, namely recombinant cystatin C (r-cystatin C) or low molecular weight kininogen were used in the a
