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MicroRNAs (miRNA) play an important role in various biological process by regulating gene expression. Their abnormal expression may lead to cancer. Therefore, analysis of such data may discover potential biological insight for cancer diagnosis. In this regard, recently many feature selection methods have been developed to identify such miRNAs. These methods have their own merits and demerits as th
The BB rat spontaneously develops insulin-dependent diabetes mellitus (IDDM) in association with marked insulitis in the islets of Langerhans. Since platelet-activating factor (PAF-acether) is involved in allergic and inflammatory reactions, we tested a PAF antagonist, Ginkgolide B (BN 52021) for potential effects on islet inflammation and diabetes. Diabetes prone BB/Wor rats were treated daily fr
The pancreases of approximately 50 days old diabetes-prone BB/Hagedorn (BB/H) and of the genetically closely related, but non-diabetic BB w-subline (control BB) rats were perfused to determine the capacity of D-glucose to release insulin before the expected development of diabetes. The BB/H rats were from a colony with 82-84% incidence of insulin-dependent diabetes mellitus (IDDM) by 140 days of a
The effect on serum lipids, lipoprotein fractions, body composition, weight gain and uremic state of including fat in intravenous nutrition was evaluated in rats with chronic uremia. Uremic rats were given high energy (1385 kJ.kg body weight-1.day-1), low nitrogen (0.6 g N.kg body weight-1.day-1) total parenteral nutrition (TPN) for 12 d with either glucose or glucose plus 30% lipids (Intralipid)
BACKGROUND: Spatial epidemiological analyses primarily depend on spatially-indexed medical records. Some countries have devised ways of capturing patient-specific spatial details using ZIP codes, postcodes or personal numbers, which are geocoded. However, for most resource-constrained African countries, the absence of a means to capture patient resident location as well as inexistence of spatial d
The orchid family is the largest in the angiosperms, but little is known about the molecular basis of the significant variation they exhibit. We investigate here the transcriptomic divergence between two European terrestrial orchids, Dactylorhiza incarnata and Dactylorhiza fuchsii, and integrate these results in the context of their distinct ecologies that we also document. Clear signals of lineag
Succinate dehydrogenase consists of two protein subunits and contains one FAD and three iron-sulfur clusters. The flavin is covalently bound to a histidine in the larger, Fp, subunit. The reduction oxidation midpoint potentials of the clusters designated S-l, S-2, and S-3 in Bacillus subtilis wild-type membrane-bound enzyme were determined as +80, -240, and -25 mV, respectively. Magnetic spin int
Operating systems code is often developed according to principles like simplicity, low overhead, and low memory footprint. Schedulers are no exceptions. A scheduler is usually developed with flexibility in mind, and this restricts the ability to provide real-time guarantees. Moreover, even when schedulers can provide real-time guarantees, it is unlikely that these guarantees are properly quantifie
Aim: The aim of this thesis was to identify risk factors for type 1 diabetes in children, evaluate the effects of participation in prospective follow-up and the safety of immune tolerance treatment with GAD-Alum in children with islet autoimmunity.Methods: Subjects from the Swedish DiPiS cohort were studied regarding risk factors, cord blood islet autoantibodies and the effects of early severe lif
[Preliminary results from bryophyte spore capsule records in the county of Skåne, southernmost Sweden] Occurrences of sporophytes are recorded by inventorers within the bryophyte flora project for Skåne. Here we present commented distribution maps with sporophyte presence/absence indicated for Calliergonella cuspidata, Dicranum scoparium, Encalypta streptocarpa, Homalothecium sericeum, Hylocomium
GPR30, or G protein-coupled estrogen receptor (GPER), is a G protein-coupled receptor (GPCR) that is currently attracting considerable attention in breast cancer and cardiometabolic regulation. The receptor was reported to be a novel membrane estrogen receptor mediating rapid non-genomic responses. However, questions remain about both the cognate ligand and the subcellular localization of receptor
Septins are an example of subtle molecular recognition whereby different paralogues must correctly assemble into functional filaments important for essential cellular events such as cytokinesis. Most possess C-terminal domains capable of forming coiled coils which are believed to be involved in filament formation and bundling. Here, we report an integrated structural approach which aims to unravel
Novelty is a core value in science, and a reliable measurement of novelty is crucial. This study proposes a new approach of measuring the novelty of scientific articles based on both citation data and text data. The proposed approach considers an article to be novel if it cites a combination of semantically distant references. To this end, we first assign a word embedding–a vector representation o
Organizations interact with their stakeholders to a large degree through social media such as Facebook, Instagram, Twitter and YouTube ( Bellucci & Manetti, 2017). There are indications that there is an increase in the use of emotional language in organizations’ external communication in social media over time, since this is thought to generate more stakeholder engagement (Weinryb et al, 2021)
The Bicoid (Bcd) protein is a primary determinant of early anterior-posterior (AP) axis specification in Drosophila embryogenesis. This morphogen is spatially distributed in an anterior-high gradient, and affects particular AP cell fates in a concentration-dependent manner. The early distribution and dynamics of the bicoid (bcd) mRNA, the source for the Bcd protein gradient, is not well understood
Proteins evolve under a myriad of biophysical selection pressures that collectively control the patterns of amino acid substitutions. These evolutionary pressures are sufficiently consistent over time and across protein families to produce substitution patterns, summarized in global amino acid substitution matrices such as BLOSUM, JTT, WAG, and LG, which can be used to successfully detect homologs
In the framework of an archaeological prospection case study conducted at the Swedish Iron Age site of Uppåkra near Lund, a large number of anomalies caused by buried archaeological remains were detected using extensive magnetic surveys. Written sources report that the Swedish army under Field marshal Gustav Horn had established a camp near the village of Uppåkra in autumn 1644, awaiting the appro
