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Objective. To study lymphocyte markers in rheumatoid arthritis (RA)-associated interstitial pneumonitis (IP) compared with idiopathic IP. Methods. Paraffin-embedded lung biopsy specimens from patients with RA (n = 15) and from those without RA (n = 16), all of whom had a diagnosis of either nonspecific IP or usual IP, were studied. Tissue sections from each patient were reviewed by a pathologist,
Increased blood glucose after a meal is countered by the subsequent increased release of the hypoglycemic hormone insulin from the pancreatic beta cells. The cascade of molecular events encompassing the initial sensing and transport of glucose into the beta cell, culminating with the exocytosis of the insulin large dense core granules (LDCVs) is termed "stimulus-secretion coupling." Impairment in
Proteins and other biomolecules contain acidic and basic titratable groups that give rise to intricate charge distributions and control electrostatic interactions. 'Charge regulation' concerns how the proton equilibria of these sites are perturbed when approached by alien molecular matter such as other proteins, surfaces and membranes, DNA, polyelectrolytes etc. Importantly, this perturbation gene
Due to the increasing interest of producing power from renewable and non-conventional resources, organic Rankine cycles are finding their place in today’s thermal energy mix. The main influencers on the efficiency of an organic Rankine cycle are the working fluid and the expander. Therefore most of the research done up to date turns around the selection of the best performance working media and th
Introduction: Lobectomy is the standard curative treatment for non-small cell carcinoma (NSCLC) of the lung. Most studies on lobectomy have focused on short-term outcome and 30-day mortality. The aim of this study was to determine both short-term and long-term surgical outcome in all patients who underwent lobectomy for NSCLC in Iceland over a 24-year period. Material and methods: The study involv
Rufous-collared sparrows (Zonotrichia capensis peruviensis) from valleys in the Atacama Desert of Chile, live in an extremely stable environment, and exhibit overlap in molt and reproduction, with valley-specific differences in the proportion of birds engaged in both. To better understand the mechanistic pathways underlying the timing of life-history transitions, we examined the relationships amon
Joubert syndrome and related disorders (JSRD) are clinically and genetically heterogeneous ciliopathies sharing a peculiar midbrain-hindbrain malformation known as the 'molar tooth sign'. To date, 19 causative genes have been identified, all coding for proteins of the primary cilium. There is clinical and genetic overlap with other ciliopathies, in particular with Meckel syndrome (MKS), that is al
Popular Abstract in Swedish Sjukdomar hos äldre har ofta annan sjukdomsbild än motsvarande sjukdom hos medelålders och yngre. Till exempel är symtomen är ofta mindre tydliga, äldre har ofta flera samtidiga sjukdomar som ger en komplex sjukdomsbild, dessutom kan ett ”mindre allvarligt” sjukdomstillstånd föra med sig betydande besvär pga annan samtidig sjukdom. Detta gäller även för depressionssjukdStudies have found that depressive states in old age that do not fulfil the criteria for major depression are clinically important depressive states. These depressive states are common in primary care patients. Therefore, studies of late-life depression from a primary care perspective are needed. A depressive rating scale, Hopkins Symptom Checklist-25 (HSCL-25), was used in a community survey in 1
Popular Abstract in Swedish Studien handlar om fysiologen Frithiof Holmgrens försök att fastställa seendets natur på experimentell väg. Avsikten är att problematisera Holmgrens intresse för synsinnet mot bakgrund av de metoder och vetenskapliga ideal som var förhärskande inom den experimentella fysiologin, det ämne som Holmgren introducerade i Sverige 1862. Generellt kan man säga att Holmgrens forThis study deals with research on the visual organ as pursued in experimental physiology during the latter half of the nineteenth-century. In the 1850's och 60's experimental physiology developed as a new, scientific discipline within the curriculum of western medicine. By opposing the natural philosophical and vitalistic viewpoint of romantic medicine and by proclaiming measuring devices, animal
Popular Abstract in Swedish Hur löser den intellektuelle politikern problem och hur skapas kontakten med den politiska omgivningen? Svaren på frågorna skall kortfattat presenteras och är intressanta för politiker, partier, väljare och forskare. Svaren visar nämligen hur intellektuella politiker under kristider producerar och presenterar innovativa lösningar som kan få stor betydelse för samhällsutA new theory on the intellectual politician, which has the ability to produce a designed type of problem-solving, has been developed from political science theory, cognitive theory as well as art theory. A cognitive concept, modified integrative complexity, consisting of four sub-concepts, frame reflection, differentiation, reframing and integration has been developed. The relation between politic
Dose calculations for treatment planning of photon beam radiotherapy require a model of the beam to drive the dose calculation models. The beam shaping process involves scattering and filtering that yield radiation components which vary with collimator settings. The necessity to model these components has motivated the development of multisource beam models. We describe and evaluate clinical photo
We present measurements of isothermal DNA-hexadecyltrimethylammonium (DNACTA) complex and pure DNA hydration at 25 degreesC using a sorption microcalorimeter. This calorimeter provides simultaneous measurement of (i) water activity (sorption isotherms) and (ii) the partial molar enthalpy of water as a function of water uptake. For pure DNA, hydration is exothermic over the studied concentration ra
The most important issue in this dissertation will be a discussion concerning metal age flint use in Scania. Since flint tools from the Bronze and Iron Ages and Medieval times have rarely been examined, there are few general guidelines in typology or morphology. It is quite clear that conversions of existing Stone Age typological schemes are unsuitable when one intends to study the often simple an
We study the rise of the so-called “gig economy” through the lens of Uber and its drivers in the United Kingdom. Using administrative data from Uber and a new representative survey of London drivers, we explore their backgrounds, earnings, and subjective well-being. We find that the vast majority of Uber drivers are male immigrants, primarily drawn from the bottom half of the London income distrib
In order to calculate building energy usage, apart from the technical characteristics, user related factors needs to be determined. Unless the user related factors are determined by specific project, the idea is to apply a standardized list of input data for a normal operation during a normal year, so the calculated energy value does not depend on variation of these factors. Such list was issued b
Microbial communities play a major role in the degradation of soil organic matter (SOM) in soils. Despite its significance, the functional diversity of the highly diverse microbial communities is poorly understood. To address this, we applied a recently developed technique, captured metagenomics, to determine the effects of land-use on the functional genetic diversity of genes involved in the carb
Polycomb proteins maintain cell identity by repressing the expression of developmental regulators specific for other cell types. Polycomb repressive complex-2 (PRC2) catalyzes trimethylation of histone H3 lysine-27 (H3K27me3). Although repressed, PRC2 targets are generally associated with the transcriptional initiation marker H3K4me3, but the significance of this remains unclear. Here, we identify
