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BACKGROUND: Lynch syndrome is a rare familial cancer syndrome caused by pathogenic variants in the mismatch repair genes MLH1, MSH2, MSH6, or PMS2, that cause predisposition to various cancers, predominantly colorectal and endometrial cancer. Data are emerging that pathogenic variants in mismatch repair genes increase the risk of early-onset aggressive prostate cancer. The IMPACT study is prospect
Introduction: While it is recognized that there are costs associated with postoperative patient follow-up, risk assessments of catastrophic health expenditures (CHEs) due to surgery in sub-Saharan Africa rarely include expenses after discharge. We describe patient-level costs for cesarean section (c-section) and follow-up care up to postoperative day (POD) 30 and evaluate the contribution of follo
Many hand-held or mixed reality devices are used with a single sensor for 3D reconstruction, although they often comprise multiple sensors. Multi-sensor depth fusion is able to substantially improve the robustness and accuracy of 3D reconstruction methods, but existing techniques are not robust enough to handle sensors which operate with diverse value ranges as well as noise and outlier statistics
Introduction: The specificity of cortisol after 1 mg dexamethasone (cortisolDST) ≥50 nmol/L as a criterion for mild autonomous cortisol secretion (MACS) is approximately 85% in patients with adrenal incidentalomas (AI). The aim was to study the associations of cortisolDST to age, BMI, and renal function. Methods: We studied 1,129 patients with AI examined from 2005 to 2015 at Skåne University Hosp
Despite being the leading cause of death worldwide, cancer still lacks precise biomarkers for effective targeting, limiting efforts to reduce mortality rates. This review explores the role and clinical significance of a newly identified long non-coding RNA, MYOSLID, in cancer progression. MYOSLID has emerged as a critical modulator in cancer progression by influencing key hallmarks such as prolife
IMPORTANCE: Repeating a prostate-specific antigen (PSA) test after an elevated measurement is a guideline-recommended component of the prebiopsy workup. However, it is unclear whether certain patients can be exempted from repeat PSA testing and proceed directly to further workup.OBJECTIVE: To determine yearly PSA variability and implications of repeating an elevated PSA in the Prostate, Lung, Colo
The Viking Age (c. 800 – c. 1050 AD) was a period of dramatic change and transformative encounters across Europe and the wider world. Ships, seafarers, and the sea were central to these developments but, paradoxically, the Viking Age is generally studied through evidence and approaches on land. This has consistently hindered scholarly understanding of the maritime dimensions of the Viking Age; sur
This thesis consists of literary case study of a classical Arabic travel narrative dictated by the Moroccan scholar and Ṣūfī Yūsuf ʾibn ʿĀbid al-Fāsī (يوسف بن عابد الفاسي) (d.1048/1638) in his new-found home in Hadramawt, Yemen. The study seeks to investigate the Ṣūfī dimension of the corpus text and address its legacy within the riḥla tradition (AR. الرحلة al-riḥla) by the usage of Ṣūfī elements,
Electrospun nanofiber membranes (ENMs) with unique porous 3D network structure exhibit properties such as high porosity and surface area, fine-tuned surface functionality and uniform pore sizes. This makes them candidates for water/wastewater applications with excellent flow. This study focuses on the fabrication of polymeric and composite ENMs from polyacrylonitrile (PAN) and nanoclay (NC) and th
microRNAs are small RNA molecules that can repress the expression of protein-coding genes post-transcriptionally. Previous studies have shown that microRNAs can also have alternative functions, including influencing target expression variation and covariation, but these observations have been limited to a few microRNAs. Here we systematically study microRNA alternative functions in mouse embryonic
Background and objective: The impact of a smoking and alcohol cessation intervention on health-related quality of life (HRQoL) following radical cystectomy (RC) is unclear. This study aimed to evaluate the effect of a 6-wk perioperative smoking and/or alcohol cessation intervention on HRQoL. A secondary objective was to assess the difference in HRQoL between patients with more than two and those w
Purpose: High-risk colon cancer may benefit from preoperative chemotherapy (preCHT), but evidence on its short-term safety and outcome is limited. Population-based evidence before its incorporation into national guidelines is lacking. Methods: Patients with final weighted stage II–III colon cancer undergoing elective resection between 2007 and 2017 were identified in the Swedish Colorectal Cancer
This article provides a step-by-step guideline for measuring and analyzing visual attention in 3D virtual reality (VR) environments based on eye-tracking data. We propose a solution to the challenges of obtaining relevant eye-tracking information in a dynamic 3D virtual environment and calculating interpretable indicators of learning and social behavior. With a method called "gaze-ray casting," we
1 I. CASE OVERVIEW Melanie Soebono and Others v. Republic of Indonesia and Others1 Country/Region : Indonesia/Jakarta Forum : Central Jakarta District Court Filing Date : 04 July 2019 Status : Decided [pending appeal] Date of Judgement : 16 September 2021 Case Category : Civil Lawsuit Domestic Laws : Indonesian Constitution; Indonesian Civil Code; Law No. 32 of 2009 on Environmental Protection and
Bakgrund: Byggprojekt i täta, urbana och aktiva miljöer ställer höga krav på logistisk koordinering, planering och hantering av materialflöden. Ökad projektkomplexitet, begränsade ytor på byggarbetsplatsen och pågående verksamheter i omgivningen skapar stora utmaningar för leveranser i byggprojekt. Dessa utmaningar inkluderar begränsad lagringskapacitet, transportrelaterade svårigheter samt behovBackground: Construction projects in dense urban and operational environments place high demands on logistics integration, planning, and material flow management. Increased project complexity, limited site space, and ongoing surrounding operations create major delivery challenges in construction projects. These challenges include limited storage capacity, transportation difficulties, and the need
Gender tests in sports have become increasingly popular amongst sports gov-erning bodies. Even the International Olympic Committee only recently, in March 2026, introduced a new rule requiring female athletes to undergo ge-netic testing to be allowed to compete in the female category. This article ex-amines gender testing in sport and the question of whether these regulations violate the human rig
Purpose: This study explores how employees from the three different diversity groups, individuals with mental health issues, neurodivergent employees and women with gendered care responsibilities, interpret return to office (RTO) policies and how these interpretations shape the employer-employee relationship. Methodology: This study presents a qualitative, interpretivist thesis grounded in symbol
