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BACKGROUND: Prostate cancers featuring an expansile cribriform (EC) pattern are associated with worse clinical outcomes following radical prostatectomy (RP). However, studies of the genomic characteristics of Gleason pattern 4 subtypes are limited.OBJECTIVE: To explore transcriptomic characteristics and heterogeneity within Gleason pattern 4 subtypes (fused/poorly formed, glomeruloid, small cribri
Patterns of future climate and expected extreme conditions are pushing design limits as recognition of climate change and its implication for the built environment increases. There are a number of ways of estimating future climate projections and creating weather files. Obtaining adequate representation of long-term patterns of climate change and extreme conditions is, however, challenging. This w
The Arctic has experienced a warming rate higher than the global mean in the past decades, but previous studies show that there are large uncertainties associated with future Arctic temperature projections. In this study, near-surface mean temperatures in the Arctic are analyzed from 22 models participating in phase 6 of the Coupled Model Intercomparison Project (CMIP6). Compared with the ERA5 rea
Rationale: Coronavirus disease (COVID-19) is an ongoing pandemic, in which obesity, hypertension, and diabetes have been linked to poor outcomes. Obstructive sleep apnea (OSA) is associated with these conditions and may influence the prognosis of adults with COVID-19. Objectives: To determine the effect of OSA on clinical outcomes in patients with COVID-19. Methods: The current prospective observa
Importance: The performance of bioprosthetic aortic valves is usually assessed in single valve models or head-to-head comparisons. National databases or registries offer the opportunity to investigate all available valve models in the population and allows for a comparative assessment of their performance. Objective: To analyze the long-term rates of reintervention, all-cause mortality, and heart
PurposeDrylands account for 47.2% of land area and contain 15.5% of global carbon (C). However, the variation in organic and inorganic C stocks across latitudinal gradients in arid and semiarid shrubland ecosystems remains understudied, and we lack in-depth understanding of the main drivers of C variation at this spatial scale.MethodsHere, we sampled soils from 95 sites across a latitudinal gradie
Early reports raised concern that use of non-steroidal anti-inflammatory drugs (NSAIDs) may increase risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19). Users of the COVID Symptom Study smartphone application reported use of aspirin and other NSAIDs between March 24 and May 8, 2020. Users were queried daily about symptoms, COVID-19 testing, and healthcare seeki
According to conventional wisdom, improving energy efficiency is an easy way to mitigate climate change and improve energy security, though the reduction in energy intensity in developed economies is largely due to offshoring energy-intensive production to developing countries. This chapter presents a contrarian view. Theory, historical evidence, and time series analysis suggest that the economy-w
Visual systems adapt to different light environments through several avenues including optical changes to the eye and neurological changes in how light signals are processed and interpreted. Spectral sensitivity can evolve via changes to visual pigments housed in the retinal photoreceptors through gene duplication and loss, differential and coexpression, and sequence evolution. Frogs provide an ex
Purpose: This paper aims to challenge the view of Sweden’s climate leadership by problematizing its domestic climate adaptation governance and highlighting the need for a more holistic view of adaptation. The paper highlights aspects that are troublesome for not only the built environment along coastlines but also the future of Sweden’s standing as a climate leader. The paper concludes with recomm
BACKGROUND: Pesticides cause a wide range of deleterious health effects, including metabolic disorders. Little is known about the effects of dietary pesticide exposure on body weight (BW) change in the general population. We aimed to investigate the role of dietary pesticide exposure in BW change among NutriNet-Santé participants, focusing on potential sexual dimorphism.METHODS: Participants compl
Atmospheric aerosol particles typically consist of inorganic salts and organic material. The inorganic compounds as well as their hygroscopic properties are well defined, but the effect of organic compounds on cloud droplet activation is still poorly characterized. The focus of the present study is the organic compounds that are surface active i.e. tend to concentrate on droplet surface and decrea
Disentangling the factors shaping species distributions remains a central goal in biogeography, ecology and evolutionary biology. The extrinsic pressures that may facilitate range shifts, such as climatic factors or biotic interactions are well known. However, in contrast, the possible intrinsic factors are manifold and hard to generalize across taxa. Recently, several theoretical studies have inv
Climate change constitutes a major collective action problem because it affects all of humanity, and an effective response to it is unlikely if individual actors prioritize their own interests independently. The international community has thus acknowledged that the issue requires a collective response. Climate change has also been considered a common concern of humankind. The concept of common co
De humanitära interventionerna i slutet på 90-talet gav upphov till en mängd diskussioner och skapade skiljaktigheter mellan världens nationer. Till följd av detta inrättades The International Commission on Intervention and State Sovereignty (ICISS) som i december 2001 introducerade The Responsibility to Protect (R2P). Förslaget som utarbetades omfattar flera aspekter av staters ansvar att agera vThe humanitarian interventions that occurred in the late 90’s gave rise to a variety of discussions and caused divergence between the world nations. Following this the Canadian government formed The International Commission on Intervention and State Sovereignty (ICISS) which later in December 2001 introduced The Responsibility to Protect (R2P). The presented proposal by the commission comprises se
Testamenten löper risk att utsättas för olika former av sabotage. För att minska risken finns det en rad skyddsregler i lagstiftningen, men de är av äldre art. Vår arvs-och testamentsrätt baseras på ÄB som är från 1958 men efter många år har det föreslagits en uppdatering. SOU 2025:91 har framtagits för att modernisera lagstiftningen och anpassa den till de nya förut-sättningar som finns. Några avWills run the risk of being sabotaged in different ways. To minimize the risk, there is several protection rules in the Swedish law, but they are of an older nature. Our rules about succession are based on the Inheritance Code from 1958, but after many years there has been a suggestion for an update. SOU 2025:91 has been developed to modernize the regulations and adapt them to the new conditions t
In the heart of every physical theory lies measurement theory. While classical measurements are passive probes, QMs can be viewed as active physical processes that shape the available information. Depending on the measurement type, different aspects of the information about a system are retrieved. All possible measurements in quantum physics are described by mathematical objects called Positive Op
A risk evaluation with regards to fire safety has been performed at Torpa Stenhus. The focus of the evaluation was the safety of the people inside the building in case of a fire. As part of the education for future fire protection engineers at LTH a risk evaluation report is performed in the course Brandteknisk riskvärdering (VBR054). Torpa Stenhus was built during the 15th century and is located
The Greenhouse Gas Reduction Mandate (GGRM, reduktionsplikten) is Swedish legislation focused on reducing carbon emissions by mandating that the emissions of certain fuels are reduced by a specified percentage, that percentage increasing each year. This paper investigates the rationale behind a political drive to decrease the GGRM, the cost-effectiveness of the GGRM, and the consequences of t
The Indian agriculture sector plays a vital role in the country's economy and employs a significant number of individuals. The sector's performance has been plummeting in recent years, and this decrease in growth can be attributed to factors such as the provisions provided to farmers by the government. With the introduction of the Farm Laws in the country, the goal was to provide more free
