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IgA nephropathy (IgAN) and Henoch-Schönlein purpura (HSP) are diseases characterized by IgA deposits in the kidney and/or skin. Both may arise after upper respiratory tract infections, but the pathogenic mechanisms governing these diseases remain unclear. Patients with IgAN (n = 16) and HSP (n = 17) were included in this study aimed at examining whether IgA-binding M proteins of group A streptococ
Complement C2 deficiency (C2D) is associated with immunological diseases and increased susceptibility to invasive infections caused by encapsulated bacteria such as Neisseria menigitidis. In this study we evaluate the immunogenicity of vaccination against N. menigitidis in C2D. C2D patients (n=22) and controls (n=52) were given a tetravalent meningococcal polysaccharide vaccine. Serum bactericidal
Transplantation of allogeneic embryonic neural tissue is a potential treatment for patients with Parkinson's and Huntington's diseases. The supply of human donor tissue is limited, and alternatives such as the use of animal (e.g., porcine) donor tissue are currently being evaluated. Before porcine grafts can be used clinically, strategies to prevent neural xenograft rejection must be developed. Kn
Objective. Antileukoproteinase (ALP) is a physiologic inhibitor of granulocytic serine proteases. The present study was undertaken to investigate its therapeutic benefit in an antibody-transfer model of erosive polyarthritis and to elucidate its potential to interfere with immune complex-dependent inflammatory pathways. Methods. Arthritis development was induced in male (BALB/c x B10.Q)F-1 mice by
Introduction: Recent haemophilia treatment advances include new recombinant FVIII (rFVIII) products with improved pharmacokinetic (PK) properties that aim to reduce the burden of prophylaxis. These treatments are commonly referred to as extended half-life rFVIII products (EHL rFVIII). There is no uniform definition of what constitutes an EHL rFVIII. Such a definition would help physicians, patient
Hu11B6 is a monoclonal antibody that internalizes in cells expressing androgen receptor (AR)-regulated prostate-specific enzyme human kallikrein-related peptidase 2 (hK2; KLK2). In multiple rodent models, Actinium-225-labeled hu11B6-IgG1 ([225Ac]hu11B6-IgG1) has shown promising treatment efficacy. In the present study, we investigated options to enhance and optimize [225Ac]hu11B6 treatment. First,
Tissue factor pathway inhibitor-2 (TFPI-2) has previously been characterized as an endogenous anticoagulant. TFPI-2 is expressed in the vast majority of cells, mainly secreted into the extracellular matrix. Recently we reported that EDC34, a C-terminal peptide derived from TFPI-2, exerts a broad antimicrobial activity. In the present study, we describe a previously unknown antimicrobial mode of ac
It has previously been shown that sera from multiparous women have increased levels of anti-idiotypic antibodies specific for anti-HLA molecules. γ-Globulins prepared from these sera may be superior to commercial preparations of intravenous γ-globulin (IVIg) for inhibiting HLA alloimmunization. To test this, F(ab′)2 fragments prepared from either commercial IVIg or from the sera of men or multipar
Background: 4-1BB (CD137) is a co-stimulatory receptor highly expressed on tumor reactive effector T cells and NK cells, which upon stimulation prolongs persistence of tumor reactive effector T and NK cells within the tumor and induces long-lived memory T cells. 4-1BB agonistic antibodies have been shown to induce strong anti-tumor effects that synergize with immune checkpoint inhibitors. The firs
Background: Nigeria is a major contributor to the global malaria burden. The genetic diversity of malaria parasite populations as well as antibody responses of individuals in affected areas against antigens of the parasite can reveal the transmission intensity, a key information required to control the disease. This work was carried out to determine the allelic frequency of highly polymorphic Plas
Special Area Studies, spring 2025 Special Area Studies ACCESSIBLE TO ALL EXCHANGE STUDENTS, SPRING 2025 SAS COURSES AT THE JOINT FACULTIES OF HUMANITIES AND THEOLOGY Information may be requested from: international@ht.lu.se | Webpage: www.ht.lu.se/en/international/ MONDAY A.M. SASH65 History of the Holocaust 20 January –10 March 10.15 –12.00 (Mon. and Thur.) Department of History LUX SASH66 One Wo
Microsoft Word - examensarbete v6.docx Master’s Dissertation Structural Mechanics Report TV SM -5246 ERN EST BJÖ RK LU N D and A X EL C H RISTO FFERSSO N C O M PU TA TIO N A L M O D ELIN G A N D EX PER IM EN TA L V ER IFIC A TIO N O F SO FT-B O D Y IM PA C T O N G LA SS STR U C TU R ES COMPUTATIONAL MODELING AND EXPERIMENTAL VERIFICATION OF SOFT-BODY IMPACT ON GLASS STRUCTURES ERNEST BJÖRKLUND and
https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5246.pdf - 2026-07-16
Spel om pengar utgör en riskfylld del av dagens samhällshandel. Överdrivet spelande och de negativa konsekvenserna av spelande ämnas motverkas genom spelansvarsåtgärderna i spellagen (2018:1138). En av dessa ansvarsåtgärder är kreditförbudet, 14 kap. 8 § spellagen, som förbjuder licenshavare och spelombud från att själva erbjuda eller lämna kredit för spelinsatser. Regeringen har nyligen i prop. 2Gambling constitutes a risky aspect of today’s modern economy. Excessive gambling and the negative consequences of gambling are indented to be countered through the gambling responsibility measures in the Swedish Gambling Act (2018:1138). One of the responsibility measures is the credit ban, Chapter 14 Section 8 of the Gambling Act, which prohibits license holders and gambling agents from offering
