https://www.byggmek.lth.se/fileadmin/byggnadskonstruktion/publications/THID/berneheim.pdf - 2026-07-12
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In this paper, the authors report the use of liquid-liquid partition chromatography (LLPC) in an aqueous polyethylene glycol (PEG)/dextran two-phase system to compare the surface properties (partition properties) of human antibodies and fragments thereof. The surface properties of all the monoclonal antibodies of different classes and subclasses investigated were within the same broad range as tha
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To investigate the effects of a vitamin D3 analogue (BXL628) in a model of chronic cystitis, as calcitriol analogues might be an interesting new therapeutic option for interstitial cystitis, for although the cause of the disease remains unclear, the increase in mast cells in the mucosa and detrusor muscle are significant. We devised a mouse model of allergen-induced allergic cystitis that is assoc
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A one-step HPLC method was developed for the purification of protein G, a cell wall molecule from group C and G streptococci with immunoglobulin G- and albumin-binding properties. Lysed Escherichia coli bacteria infected with lambda-phages containing the protein G gene from group G streptococci were used as a starting material for the preparations. The lysate was applied to a column with immobiliz
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Glycoprotein B (gB, gpUL55) is a major antigen for the induction of neutralizing antibodies against human cytomegalovirus, making it an attractive antigen for active and passive immunoprophylaxis. The immunodominant region on gB is the antigenic domain 1 (AD-1), a complex structure which requires a minimal linear amino acid sequence of more than 75 amino acids (aa 552-635) for antibody binding. We
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The Group A streptococcus (GAS) (Streptococcus pyogenes) is a significant human pathogen known for causing a diverse range of diseases, spanning from mild diseases such as pharyngitis to life-threatening diseases such as necrotizing fasciitis. Its virulence comes from a plethora of immune evasion mechanisms, but the M protein with its hypervariable region and ability to bind human proteins, stands
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The aviation industry is perceived as being unsustainable in the long term due to foreseen continuous growth and the use of finite natural resources. To become more sustainable airlines need to address sustainability in their business model and business strategies. This research explores how the two airline carrier types, Ryanair, an LCC, and Scandinavian Airlines (SAS), an FSC, have addressed sus
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In the European Union (EU), mandatory durability ecodesign requirements have recently been set for some products, including lighting products; further development of durability standards is also expected in the future. Durability standards can bring environmental and consumer benefits, but the question remains about what optimal durability is. In this paper, the product lifetime aspect of durabili
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Breaking promises might be easier if one faces unexpectedly high costs for keeping them. Inspired by the ‘pledge and review’ mechanisms of the Paris Agreement, we investigate the role of cost uncertainty for both initial non-binding pledges and the subsequent voluntary provision of public goods. Without a pledge review process, we find that cost uncertainty not only leads to rather conservative pl
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Downtimes in a manufacturing cell, a production line or an individual machine are characterized by a complex statistical behavior that their frequency and duration display. The work reported here concerns likenesses and differences between various statistical distributions that apply to functional times (TBF) and downtimes (DT) in connection with different discrete manufacturing processes. The TBF
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Downtimes in a manufacturing cell, line or individual machines are characterized by a stochastic behavior that their frequency and their duration display. A method is presented here for analyzing this dynamic behavior from a cost perspective. An important element of the method is statistical analysis of downtimes, including empirical distribution functions pertaining to downtimes of specific types
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Grid connected renewable energy systems are becoming popular due to reasons such as rapid escalation of energy prices, depletion of fossil fuel resources and pollutant emitted by conventional energy sources. Therefore, technologies for incorporating renewable energy technologies into the existing electricity grid needs to be researched more considering the changes in grid architecture. This study
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Coordinated Multi Point (CoMP) transmission and reception techniques are used in order to improve the performance of single or multiple cells in wireless systems. A system using CoMP techniques is capable of jointly optimizing its transmission and/or reception and, hence, achieving higher performance. In this work, performance evaluation of three CoMP techniques are performed based on simulations
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A general framework for the formulation and analysis of an overall decision support index is discussed. It is indicated that such an index allow evaluation of the combined effects of both design and operation (i) during the planning phase of new WWTPs, as well as (ii) for the evaluation of new operational strategies versus traditional expansions of plants already in operation. Attention is drawn t
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The COST2100 channel model is a reference channel model which provides dynamic multiple-input multiple-output channel responses for radio system simulations. In this paper, channels created by the COST2100 model were compared to channel measurements in order to understand behaviours of the model. Model parameters of the COST2100 model were derived by dynamic double-directional channel measurements
