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We report the development of a platform of dual targeting Fab (DutaFab) molecules, which comprise two spatially separated and independent binding sites within the human antibody CDR loops: the so-called H-side paratope encompassing HCDR1, HCDR3 and LCDR2, and the L-side paratope encompassing LCDR1, LCDR3 and HCDR2. Both paratopes can be independently selected and combined into the desired bispecifWe report the development of a platform of dual targeting Fab (DutaFab) molecules, which comprise two spatially separated and independent binding sites within the human antibody CDR loops: the so-called H-side paratope encompassing HCDR1, HCDR3 and LCDR2, and the L-side paratope encompassing LCDR1, LCDR3 and HCDR2. Both paratopes can be independently selected and combined into the desired bispecif

Online platforms devoted to investigating criminal cases or mysteries are often seen as reaching outwards to identify suspects, promote punishment, and try to solve cases. Simultaneously, internal interactions between posters motivate them to contribute, even to outdo one another, and so a team spirit emerges. This article analyzes a lengthy thread on a Swedish Internet discussion forum, FlashbackOnline platforms devoted to investigating criminal cases or mysteries are often seen as reaching outwards to identify suspects, promote punishment, and try to solve cases. Simultaneously, internal interactions between posters motivate them to contribute, even to outdo one another, and so a team spirit emerges. This article analyzes a lengthy thread on a Swedish Internet discussion forum, Flashback

This article compares Swedish social workers, teachers, and journalists’ experiences of workplace violence. It addresses similarities and differences between the three professional groups in terms of who exposed them to workplace violence, what it was about, and what triggered it. The article is based on an online survey study, and the findings suggest that consumer-related violence from target gr

Renewable energy pursuit and implementation are undoubtedly one of the most important steps in sustainable development across the globe. So far there are several developed high-income countries in the world, that have replaced their fossil fuel-powered electricity systems for renewable energy technologies, however, most of the world still relies on non-renewable energy sources. This research will

The recent increase in climate warming has further increased the interest of climate policy in the European Union. In order to adapt to the climate change, policies must be implied to guarantee adaptation, and they need to be effective, even if members of the supranational organization have significant economic growth. Therefore, this research will examine what policies EU member nations, Ireland

The aim of this thesis is to present issues related to cross-border taxation of employee stock options and critically inquiring whether the Swedish Supreme Administrative Court’s reasoning about comparable situations in the two rulings concerning taxation of stock options is supported by ECJ case law. On 4th of November 2015, the Supreme Administrative Court in Sweden issued two rulings concerning

The surge in revenue from real-time auctions for online display advertisement has spurred great research interest into how to design optimal mechanisms for these auctions, with respect to both buyers and sellers. This thesis focuses on some recent proposals on how to modify the Vickrey auction, which has been dominating the world of real-time auctions for the past decade, in order to better accomm

This thesis would like to explore how people who are part of marginalized groups share their experiences through the podcast format and analyze how people, who do not necessarily identify themselves with one or all the groups discussed in the podcast, relate to the information shared by the guest on the platform. Podcasts can provide essential insights into how marginalized groups use technology t

Over the past years, big data analytics (BDA) has gained more attention in both academic fields and business communities, and it was perceived as very beneficial for organizations. However, taking into consideration the quick and chaotic nature of its evolution, in addition to its high dependence on cutting edge technologies, BDA implementations were characterized as vague and risky projects with

The purpose of this study was to describe how life changes in psychotherapists’ own lives have affected their work. The topic was explored with a qualitative approach. The method was reflecting conversation. The result mainly illustrated how psychotherapists’ life changes and crises had affected them personally, rather than professionally. The psychotherapists mainly shared how life changes had le

Flood risk is influenced not only by climate change but also underlying factors including unplanned urbanization, environmental degradation, poverty, social inequalities and weak governance. Given its complexity, effective flood risk management requires a better understanding of its conceptual context and comprehensive assessments that beyond hazard consider exposure, vulnerability and capacity. T