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Background: Fremanezumab (TEV-48125) is a fully humanized anti-calcitonin gene-related peptide (CGRP) monoclonal antibody (mAb) that has shown positive results in the prevention of episodic migraine and chronic migraine. Previous preclinical studies have revealed CGRP antagonistic effects on intracranial arteries (ICA). The aim of the study was to evaluate the in vitro antagonistic effects of frem

1. Motivation, specific objectiveTo evaluate the first prototype of a home lighting system, we used a full-scale model of a studio apartment in the laboratory of the School of Architecture at Lund University. The personalised home lighting system is based on LEDs, wearable sensors and a mobile phone app to produce lighting tailored to the individual’s needs. Drawing on participant interviews (n =

Fetal experience forms the basis for postnatal life. This relationship may be obvious in the newborn infant, although it is sometimes not apparent until later in development. One fetal condition with known implications for later life is intrauterine growth restriction (IUGR), which ranges from being an important factor in perinatal mortality to affecting morbidity in adulthood. The process of grow

Background: The causes and effects of anastomotic leakage after anterior resection are difficult to study in small samples and have thus been evaluated using large population-based national registries. To assess the accuracy of such research, registries should be validated continuously. Material and methods: Patients who underwent anterior resection for rectal cancer during 2007–2013 in 15 differe

Background: The digestion of food is known to alter the hemodynamics of the body significantly. The purpose of this study was to study the postprandial changes in stroke volume (SV), cardiac output (CO) and left ventricular (LV) longitudinal systolic and diastolic functions measured with tissue Doppler imaging, in relation to gastric emptying rate (GER), satiety, and glucose and insulin concentrat

Background. Genital prolapse is a common and handicapping form of pelvic floor dysfunction. To explain its genesis as a result of endopelvic connective tissue weakness, the collagen state was analyzed in women with and without genital prolapse. Methods. Punch biopsies from the paraurethral ligaments were obtained during the operation from 22 women undergoing surgery for genital prolapse. As contro

Objectives: To investigate side by side the effects on serum lipoproteins and postprandial glucose and insulin concentrations of beverages enriched with 5 or 10 g of beta-glucans from oats or barley. Design and setting: An 8-week single blind, controlled study with five parallel groups carried out at two centres under identical conditions. Interventions: During a 3-week run-in period all subject

Severe hypoglycemia was induced in rats by insulin. The brain was fixed in situ by perfusion after the spontaneous EEG had disappeared for 30 or 60 min or after recovery had been induced for 30 or 180 min by glucose injection. Samples from the cerebral cortex from the area corresponding to the previous metabolic studies were processed for electron microscopy. The light-microscopic finding of two d

During the spring of 2003 ninety-five water bodies in southeastern Estonia were surveyed for chrysophytes. The sampling was carried out as the ice broke up, when, within two weeks, the water temperature rose from 3 degrees C to 13 degrees C. Large lakes to small pools of different water chemistry were investigated. The plankton collected was studied alive within a few hours after sampling. Prepara

OBJECTIVE: To determine the ability of montelukast, a leukotriene receptor antagonist, to allow tapering of inhaled corticosteroids in clinically stable asthmatic patients. DESIGN: Double blind, randomised, placebo controlled, parallel group study. After a single blind placebo run in period, during which (at most) two inhaled corticosteroids dose decreases occurred, qualifying, clinically stable p

SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism. We conducted a planned sub-study and analysis fro

Although many studies on mental health have been conducted among various populations during the COVID-19 pandemic, few studies have focused on post-traumatic growth (PTG) in the general population. The current study aimed to explore whether perceived social support, personality, and coping strategies are associated with PTG in the COVID-19 pandemic period. The study also investigated whether copin

The oceans continue to warm due to rising atmospheric greenhouse gas concentrations. Most climate-change studies of aquaculture species use temperature changes based on coarse-resolution climate models and without considering thermal ranges of an animal. Coarse-resolution climate models are generated by global-scale data, which is insufficient to capture the conditions of coastal areas where most

RATIONALE: This study aimed to explore whether a computer-based training in eating and nutrition for hospital nursing staff can influence the precision in nutritional treatment and care.METHOD: A pre-intervention and post-intervention study was conducted with a cross-sectional design at each time point. The settings were one intervention (IH) and two control hospitals (CH1 and CH2). Hospital inpat

The results of numerical simulations of a positive streamer development in air in a weak and uniform electric field are presented. Streamer dynamics is considered in an electrode gap of 33 mm in length and the configuration was 'protrusion on a plate-plate'. This particular configuration was chosen in order to perform direct comparison between simulated results and experimental data. The electrost

Background Recanalization of arterial duct (AD) is rarely needed. Objective The aim of this study is to report our experience regarding the feasibility and effectiveness of arterial duct recanalization in three infants and review the relevant literature. Methods and results We report on three patients with decreased pulmonary blood flow after initial palliation. The first patient had pulmonary atr

Popular Abstract in Swedish El-avfall (avfall från elektriska och elektroniska produkter) har under det senaste årtiondet blivit ett växande miljöproblem också i de mindre rika länderna (icke-OECD länder). Informell återvinning i u-länder har lett till att giftiga ämnen, som t.ex. bly och kvicksilver från tv-apparater, PVC från sladdar och bromerade flamskyddsmedel från plastkomponenter, har läcktWaste electrical and electronic equipment (WEEE) has become a salient issue in non-OECD countries. With a growing awareness about serious damages to the environment and human health from a lack of safe treatment and recycling of WEEE, there has been a search for policy responses in several of these countries. This research finds that extended producer responsibility (EPR), a policy principle that

Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING PÅ SVENSKA Graviditetsdiabetes (GDM) definieras som ett diabetestillstånd som upptäcks under graviditet. Ofta orsakas detta tillstånd av de hormonförändringar som uppträder under graviditet vilka medför en ökad insulinresistens, dvs. ett ökat motstånd mot insulinets effekter. Diagnosen GDM utesluter dock inte diabetes av annan orsak soThe aims of this work were to determine the prevalence of postpartum diabetes among women with gestational diabetes mellitus (GDM) in a prospective study 5 years postpartum; to characterize these women according to insulin secretion, insulin sensitivity, autoimmunity and genetics; and to identify possible markers and predictors for the development of manifest diabetes. The subjects were recruited

Emotion regulation and emotional work can have both positive and negative effects. Previous studies have suggested that emotion regulation is taught through early life socialization, and that this socialization may be gendered. If this were the case, we learn to regulate our emotions differently, and for some to, for instance, be socialized into suppressing their emotions may lead to negative cons