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Rates of cognitive decline in Alzheimer’s disease (AD) are extremely heterogeneous. Although biomarkers for amyloid-beta (Aβ) and tau proteins, the hallmark AD pathologies, have improved pathology-based diagnosis, they explain only 20–40% of the variance in AD-related cognitive impairment (CI). To discover novel biomarkers of CI in AD, we performed cerebrospinal fluid (CSF) proteomics on 3,397 ind
Background: Despite being the gold standard of research to determine effectiveness, randomised controlled trials (RCTs) often struggle with participant recruitment, engagement and retention. These issues may be exacerbated when recruiting vulnerable populations, such as participants with mental health issues. We aimed to update understanding of the scope of these problems in trials of health techn
BACKGROUND: Previous studies have demonstrated an association between transplantation rate per center and postoperative mortality after heart transplantation. In 2011, Sweden centralized heart transplants and waiting lists, reducing the number of centers from 3 to 2. We aimed to assess the active waiting time and pre- and post-transplant mortality before and after centralization.METHODS: Heart tra
Exposure to PM2.5 poses one of the biggest health threats, with traffic and biomass burning as dominant sources in urban areas of low-income countries. In Ethiopia, the combination of these two sources suggests a high roadside exposure. Because of a lack of resources for data collection, only few studies were conducted on roadside exposure in Ethiopia. Using low-cost sensors and student science co
In order to reduce parasite-induced mortality, hosts may be involved in mutualistic interactions in which the partner contributes to resistance against the parasite. The pea aphid, Acyrthosiphon pisum Harris (Hemiptera: Aphididae), harbours secondary bacterial endosymbionts, some of which have been reported to confer resistance against aphid parasitoids. Although this resistance often results in d
OBJECTIVES: To evaluate serum creatinine (s-creatinine) and serum cystatin C (s-cystatin C) levels and estimated glomerular filtration rate (eGFR) at different time points as predictors for mortality in patients undergoing coronary artery bypass grafting (CABG).METHODS: A total of 1638 patients undergoing elective CABG were studied prospectively over a median follow-up of 3.5 years (range, 2.0-5.0
Background: When cannulation is challenging during endoscopic retrograde cholangiopancreatography (ERCP), and the standard guidewire technique with sphincterotomy is unsuccessful, alternative cannulation techniques can be used to access the biliary tree. The purpose of this study was to compare the incidence of adverse events and cannulation success rates between transpancreatic sphincterotomy (TP
We propose symmetrical cationic trimethine cyanine dyes with β-substituents in the polymethine chain based on modified benzothiazole and benzoxazole heterocycles as probes for the detection and visualization of live and fixed cells by fluorescence microscopy. The spectral-luminescent properties of trimethine cyanines have been characterized for free dyes and in the presence of nucleic acids (NA) a
Background. Flecainide is a first-line rhythm control treatment for patients with atrial fibrillation (AF), however long-term treatment outcomes are understudied. Objective. To investigate associations of electro- (ECG) and echocardiographic indices with safety and efficacy outcomes of long-term flecainide treatment for recurrent AF. Methods. Consecutive patients with AF admitted for in-hospital f
Popular science summary Has climate change influenced flowering time of coltsfoot? Phenological events such as the onset of flowering during the spring are among the most sensitive indicators of climate change. Hence, phenological data have recently emerged as effective tools for studying the impact of climate change on species and ecosystems. In this study, I used records from herbaria and pub
Thomas Quick erkände under 1990-talet ett 30-tal mord som han påstod att han begått i Sverige, Norge, Danmark, och Finland under åren 1964-1993. Han dömdes för åtta av dem. 18 år senare, i december 2008, tar han tillbaka alla sina erkännanden av mord och begär resning för samtliga fällande domar. Detta har hittills resulterat i tre frikännande domar samt två positiva resningsbeslut. Pelle Svensson1990 Thomas Quick confessed to around 30 murders that he claimed to have committed in Sweden, Norway, Denmark and Finland around the years 1964-1993. He was convicted for eight of them. 18 years later he takes back his confessions of murder and applies for remedy for all his convictions. This has so far resulted in three acquittals and five granted trials of remedy. Pelle Svensson, lawyer and auth
Subject motion and eddy-current distortions represent significant challenges in diffusion MRI, particularly for clinical protocols utilizing "half-sphere" sampling. While the current gold standard, FSL’s eddy, employs Gaussian Process (GP) predictions to correct these artifacts, its performance can degrade under specific acquisition constraints, most notably when sampling lacks antipodal
In the following report, a fire safety evaluation of Hotel Nissastigen in central Gislaved is presented. The building itself consists of five floors, whereof two are cellar and attic. Beyond the usual hotel business, Nissastigen both offers a place to eat at their restaurant and room for conferences, as well as acting as a gathering point for tourists, thus making it vital for the local economy.
Copper and copper alloys are important material systems for the electrification of society. The high workability of the materials makes them appropriate in numerous different applications which require highly conductive properties. One main advantage of Cu and Cu-bearing alloys is the eminent ability to be repeatedly recycled without losing the advantageous properties. This raises the question whe
It’s not unusual for young people these days to take and edit a selfie. With the rise of consumerist culture and the popularity of mobile Internet, nowadays selfie applications, including beauty cameras and photo-beautification applications, have become the most well-accepted products/brands among Chinese women, who have grown accustomed to showing only one exquisitely edited face in digital photo
Association for computer aided genealogy research of Sweden(DIS) is investigating the possibility of a nationwide genealogical database (RGD) of Sweden's historical population. The finished database should contain basic information about individuals' names, birth, marriage, death, and individuals' relationships such as father, mother, husband/wife and children. This will make up a kind
BACKGROUND: Treatment for breast cancer poses major challenges and leads to a variety of side-effects and problems that affect life for a long time. Experiences and symptoms vary, and research indicates a lack of structures for ensuring individualized rehabilitation. This qualitative focus group study aims to explore the experience of women with BC after participating in a complex randomized contr
Background: The European Union's 7th Framework Programme (EU's FP7) project HEALS – Health and Environment-wide Associations based on Large Population Surveys – aims a refinement of the methodology to elucidate the human exposome. Human biomonitoring (HBM) provides a valuable tool for understanding the magnitude of human exposure from all pathways and sources. However, availability of specific bio
BACKGROUND: Centrally inserted central catheters (CICCs) are indispensable in modern healthcare, but unfortunately, come with complications. Catheter-related thrombosis is a well-known complication reported to occur in 5-30% of patients with CICC. There is a paucity of studies that report the incidence of catheter-related thrombosis after the introduction of real-time ultrasound insertion guidance
