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We describe and test an implicit solvent all-atom potential for simulations of protein folding and aggregation. The potential is developed through studies of structural and thermodynamic properties of 17 peptides with diverse secondary structure. Results obtained using the final form of the potential are presented for all these peptides. The same model, with unchanged parameters, is furthermore ap
Abstract Heart failure is a common and disabling disease with high mortality that carries substantial societal costs. Current therapeutic strategies are aimed at relieving symptoms, avoiding hospitalization, and prolonging life, but disease progression is ultimately inevitable. MicroRNAs (miRNAs) are short, non-coding RNA molecules with pervasive roles in eukaryotic biology, annealing to complimen
The utility of the GHOST(3) cell assay has been evaluated for testing coreceptor use of primary human immunodeficiency virus type 1 (HIV-1) isolates. GHOST(3) cells were derived from the human osteosarcoma cell line, HOS, and have been engineered to stably express CD4 and one or another of the chemokine receptors CCR3, CCR5, CXCR4, Bonzo, or the orphan receptor BOB. The Indicator cell line carries
Sampling is normally done periodically in time. For linear time invariant systems this leads to closed loop systems that linear and periodic. Many properties can be investigated by considering the behavior of the systems at times that are synchronized with the sampling instants. This leads to drastic simplifications because the systems can be described by difference equations with constant coeffic
This thesis deals with control of production at large-scale process industrial sites in the presence of disturbances. The main focus is on disturbances in the supply of utilities such as steam, cooling water and electricity. A general method for reducing the revenue loss due to disturbances in utilities is introduced, which may provide both proactive and reactive disturbance management strategies.
Context. The inner disc, which links the thin disc with the bulge, has been somewhat neglected in the past because of the intrinsic difficulties in its study, among which crowding and high extinction. Open clusters located in the inner disc are among the best tracers of its chemistry at different ages and distances. Aims. We analyse the chemical patterns of four open clusters located within 7 kpc
We present a novel visibility algorithm for rendering motion blur with per-pixel anti-aliasing. Our algorithm uses a number of line samples over a rectangular group of pixels, and together with the time dimension, a two-dimensional spatio-temporal visibility problem needs to be solved per line sample. In a coarse culling step, our algorithm first uses a bounding volume hierarchy to rapidly remove
Popular Abstract in Swedish Idén om ett särskilt slag av algebraiska strukturer, kallade "vertexoperator-algebror", uppstod på 1980-talet. Dessa algebror används för att formulera fenomen inom fysikens strängteori. Närmare bestämt beskrivs partiklar inom denna teori som vibrerande linjer (eller slutna öglor) snarare än punkter, och algebrornas operatorer avser att visa hur två sådana strängar kan The main purpose of this thesis is the study of the structure and representation theory of simple vertex operator algebras (VOAs) of affine type at admissible levels. To do this, it is crucial to obtain knowledge of the singular vectors which generate the maximal submodules, with respect to which these VOAs appear as irreducible quotients, and therefore a substantial part of the text is devoted to
This licentiate thesis focuses on clustered parametric models for estimation of line spectra, when the spectral content of a signal source is assumed to exhibit some form of grouping. Different from previous parametric approaches, which generally require explicit knowledge of the model orders, this thesis exploits sparse modeling, where the orders are implicitly chosen. For line spectra, the non-l
The overall aim of this thesis was to study life satisfaction (LS) and factors associated to LS in the group aged 78 and above. As an aid in interpreting the findings, Baltes’ and Baltes’ theory of selective optimisation with compensation (SOC) was used. All four studies included the same studypopulation who were followed for three years in the study Good Aging in Skåne, a national, randomized, po
The principal fate during litter decomposition and mineralization is rather well established only for a limited number of elements, mainly essential plant nutrients and a few potentially very toxic metals. Elements which occupy the majority of the positions in the periodical system seems almost unknown in this context. The objectives were, therefore to assess differences in the behavior of 58 mine
The expression and activities of constitutive nitric oxide synthase (cNOS) and inducible nitric oxide synthase (iNOS) in relation to insulin and glucagon secretory mechanisms were investigated in islets isolated from rats subjected to total parenteral nutrition (TPN) for 10 d. TPN is known to result in significantly increased levels of plasma lipids during the infusion time. In comparison with isl
Lyme borreliosis (LB) is the most common vector-borne disease in the northern hemisphere, and southern Sweden is a highly endemic area. In over 70% of the cases, LB is represented by the non-disseminated cutaneous form erythema migrans (EM). This thesis has its focus on EM from a primary health care perspective in southern Sweden, including aspects on epidemiology, the clinical picture, gender dif
Popular Abstract in Swedish Vi vill bevara naturbetesmarker och deras skönhet, vilken bland annat utgörs av de olika växtarter som förekommer där. Men idag finns det tyvärr inte många betesmarker kvar. Naturbetesmarkerna har under de senaste två sekelerna försvunnit på grund av ökad eller minskad markanvändning, där betesmarker blivit omvandlade till antingen åkermark eller skog. Bristen på betesmLarge areas of grazed, species rich semi-natural grassland were lost in Europe during the last two centuries and as a consequence led to decreases in grassland specialist species. Therefore, today the “restoration” of grassland on previously arable fields is recommended for the protection of grassland specialists. Even “substitute habitats” for lost grasslands are discussed as temporary alternativ
The purpose of this article is to present and discuss the development of a system for assessing and improving healthcare organisations. The system components comprise (1) a framework or model for assessing, measuring, diagnosing and improving healthcare organisations, (2) a simple methodology for data collection, data analysis and prioritising improvement areas and (3) an index named ILL (innovati
Popular Abstract in Swedish Leukemi kännetecknas av en okontrollerad tillväxt av omogna vita blodkroppar och orsakas av förvärvade genetiska förändringar. Genetiska förändringar eller avvikelser, som är drivande i cancerutvecklingen, uppstår när normala celler delar sig. Identifiering av sådana förändringar på gen-och kromosomnivå är av stor klinisk betydelse. Behandling styrs av vilka genetiska aAcute lymphoblastic leukemia (ALL) affects individuals at all ages, with peak incidences in children <4 years and adults >50 years. ALL is broadly categorized into B-cell precursor (BCP) and T-cell ALL with specific clinical features associated with outcome. In contrast to pediatric ALL, which has a favorable prognosis, adult ALL is associated with a much poorer outcome with less than 40% overall
Non-contact trapping using acoustic standing waves has shown promising results in cell-based research lately. However, the devices demonstrated are normally fabricated using microfabrication or precision machining methods leading to a high unit cost. In e.g. clinical or forensic applications avoiding cross-contamination, carryover or infection is of outmost importance. In these applications dispos
