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MOTIVATION: Massively parallel reporter assays (MPRA) enable systematic screening of DNA sequence variants for effects on transcriptional activity. However, convenient analysis tools are still needed. RESULTS: We introduce MPRAscore, a novel tool to infer allele-specific effects on transcription from MPRA data. MPRAscore uses a weighted, variance-regularized method to calculate variant effect size
Background The impact of the prophylactic vaccine against human papillomavirus (HPV) types 6, 11, 16, and 18 (HPV6/11/16/18) on all HPV-associated genital disease was investigated in a population that approximates sexually naive women in that they were "negative to 14 HPV types" and in a mixed population of HPV-exposed and -unexposed women (intention-to-treat group). Methods This analysis studied
Human epidermal growth factor receptor 2 (HER2) is overexpressed and/or amplified in 15-20% of all breast cancers, and is associated with an aggressive tumour type with impaired prognosis and a predictive marker for trastuzumab treatment. HER2 status can be determined by immunohistochemistry (IHC) at protein level and by fluorescence in situ hybridisation (FISH) analysing gene amplification, and i
OBJECTIVES: the purpose of this study was to assess the predictive accuracy of conventional cardiovascular risk factors for incident heart failure and atrial fibrillation, and the added benefit of multiple biomarkers reflecting diverse pathophysiological pathways. BACKGROUND: heart failure and atrial fibrillation are interrelated cardiac diseases associated with substantial morbidity and mortality
As part of the green transition, a current trend in the construction sector is to utilize more wood and lightweight composites, aiming at a reduction of the embodied energy in buildings. At the same time, with a focus on circularity and reuse, large-span structures are preferable, since they provide more flexibility for future uses of the building. The mix of large spans and lightweight structures
The aim of this note is to validate Wagstaff and van Doorslaer's approach of constructing a continuous health measure to be used in the analysis of inequalities in health. We calculate health concentration indices for Uppsala County in Sweden based on three different health status measures: health measured according to the WvD approach based on a self-assessed categorical health measure, health me
Importance: Twin studies have assessed sibling resemblance for major depression (MD) but cannot address sources of resemblance across generations. Objective: To clarify the relative importance of genetic and rearing effects on the parent-offspring resemblance for MD. Design: This Swedish population register-based study examined parents and children from the following 5 family types: intact (2 041
Light-use efficiency (LUE), which quantifies the plants' efficiency in utilizing solar radiation for photosynthetic carbon fixation, is an important factor for gross primary production estimation. Here we use satellite-based solar-induced chlorophyll fluorescence as a proxy for photosynthetically active radiation absorbed by chlorophyll (APARchl) and derive an estimation of the fraction of APARchl
This paper presents and assesses the cooling integration of electrical machines with concentrated windings. A conventional coil in a concentrated winding with forced cooling applied on the exterior coil surfaces is replaced by an alternative solution where the coil is opened up in a laminar structure with the intention of the coolant fluid penetrating the coil and removing the interior heat. This
Background: Few tools evaluates quality of movements in individuals with knee osteoarthritis (OA). The Test for Substitution Patterns (TSP) is developed to measure the ability to perform five functional movements regarding postural control and altered movement patterns (1). TSP is validated and reliable in individuals with anterior cruciate ligament injury, but has not yet been evaluated in indivi
The control-rod elements in a boiling-water reactor contain natural boron carbide (B4C) powder, used as neutron-absorber material and clad in stainless-steel blades. During in-reactor service, the internal production of helium gas and point defects in neutron-irradiated boron carbide cause swelling which can induce significant contact stresses in the blade causing, eventually, stress-corrosion cra
Background and Objectives: There is considerable heterogeneity in the association between increasing β-amyloid (Aβ) pathology and early cognitive dysfunction in preclinical Alzheimer disease (AD). At this stage, some individuals show no signs of cognitive dysfunction, while others show clear signs of decline. The factors explaining this heterogeneity are particularly important for understanding pr
Background: Cognitive impairment is common following out-of-hospital cardiac arrest (OHCA), but the nature of the impairment is poorly understood. Our objective was to describe cognitive impairment in OHCA survivors, with the hypothesis that OHCA survivors would perform significantly worse on neuropsychological tests of cognition than controls with acute myocardial infarction (MI). Another aim was
Building information modeling (BIM) and building energy modeling (BEM) are two key tools to make the transition to net-zero energy buildings (NZEB). However, a recent literature review indicated that the conversion from BIM to BEM is currently dysfunctional, due to limitations regarding competencies, processes, and technology. In this article, a case study is presented to show how the information
Background: Both single factors and composite measures have been suggested to predict mortality in patients with chronic obstructive pulmonary disease (COPD) and there is a need to analyze the relative importance of each variable. Objective: To explore the predictors of mortality for patients with COPD in relation to respiratory, cardiac, and malignant causes, as well as all causes of death. Metho
Importance: The concept of embolic stroke of undetermined source (ESUS) unifies a subgroup of cryptogenic strokes based on neuroimaging, a defined minimum set of diagnostic tests, and exclusion of certain causes. Despite an annual stroke recurrence rate of 5%, little is known about the etiology underlying recurrent stroke after ESUS. Objective: To identify the stroke subtype of recurrent ischemic
