Filtyp
The bioactivity of neuropeptide Y (NPY) is either N-terminally modulated with respect to receptor-selectivity by dipeptidyl-peptidase 4 (DP4)-like enzymes or proteolytic degraded by neprilysin or meprins, thereby abrogating signal transduction. However, neither the subcellular nor the compartmental differentiation of these regulatory mechanisms is fully understood. Using mass spectrometry, selecti
Thyroid hormone level has been positively associated with breast cancer risk and with breast cancer cell proliferation and growth. Although breast cancer is a heterogeneous disease, this is the first study assessing pre-diagnostic levels of free triiodothyronine (fT3), free thyroxine (fT4), thyroid-stimulating hormone (TSH), and thyroid peroxidase antibodies (TPO-Ab) in relation to breast cancer s
The perfusion-/diffusion-weighted imaging (PWI/DWI) mismatch and the diffusion/fluid attenuated inversion recovery (DWI/FLAIR) mismatch are magnetic resonance imaging (MRI) markers of evolving brain ischemia. We examined whether the DWI/FLAIR mismatch was independently associated with the PWI/DWI mismatch. Furthermore, we determined whether the presence of the DWI/FLAIR mismatch in patients with t
Phosphatidylethanol (PEth) is a direct ethanol metabolite, and has recently attracted attention as biomarker of ethanol intake. The aims of the current study are: (1) to characterize the normalization time of PEth in larger samples than previously conducted; (2) to elucidate potential gender differences; and (3) to report the correlation of PEth with other biomarkers and self-reported alcohol cons
A 14Cr ODS steel was characterized at elevated temperatures with regard to its behavior in small punch and uniaxial creep tests and in low cycle fatigue tests. A comparison of small punch and uniaxial creep tests at 650°C revealed a strong anisotropy of the material when strained parallel and perpendicular to the extrusion direction with rupture times being several orders of magnitude lower for th
Context: First-degree relatives of patients with type 2 diabetes (FH+) have been shown to have decreased energy expenditure and decreased expression of mitochondrial genes in skeletal muscle. In previous studies, it has been difficult to distinguish whether mitochondrial dysfunction and differential regulation of genes are primary (genetic) or due to reduced physical activity, obesity, or other co
Objective. This study was undertaken to investigate the previously reported association of the STAT4 polymorphism rs7574865 with rheumatoid arthritis (RA) in 3 different European populations from Spain, Sweden, and The Netherlands, comprising a total of 2,072 patients and 2,474 controls. Methods. Three different cohorts were included in the study: 923 RA patients and 1,296 healthy controls from Sp
Introduction: Identification of suitable candidates for cardioversion currently is not based on individual electrical and mechanical atrial remodeling. Therefore, this study analyzed the meaning of atrial fibrillatory rate obtained from the surface ECG (as a measure of electrical remodeling) and left atrial size (as measure of mechanical remodeling) for prediction of early atrial fibrillation (AF)
Total and regional cerebral glucose metabolism (CMRgl) was measured by positron emission tomography with 2-(F-18) fluoro-2-deoxy-D-glucose ((18)FDG) in 20 term infants with hypoxic ischemic encephalopathy (HIE) after perinatal asphyxia. All infants had signs of perinatal distress, and 15 were severely acidotic at birth. Six infants developed mild HIE, twelve moderate HIE, and two severe HIE during
Tropicalizing a technology entail adapting it to a tropical climate. This paper analyzes how an innovative solution for decarbonization – the green hydrogen - is introduced to Costa Rica. This research examines a niche trying to enter a sector under construction, contributing to the growing literature about this emerging sector. This thesis deeply examines the green hydrogen niche, building an inn
The end of the Decade of Education for Sustainable Development in the present year marked a scenario to evaluate the achievement made among nations. However the success of implementation of Education for Sustainable Development (ESD) is not equal as well the information available on the subject depens on the country. The aim of the thesis is to deliver a current status and recommendations for impr
This thesis looks at the asylum policy of Turkey, on its path to EU accession. This thesis accepts the hypothesis that a rigid nation state practice is a hindrance to the development of human rights and examines this issue in the context of Turkey. The research question of this thesis asks; is there a possibility to gain decent life conditions for refugees in Turkey? Is the EU membership/accession
Populärvetenskaplig sammanfattning: Havsnivåförändringar på södra Grönland. Den globala havsnivån har förändrats under den nuvarande mellanistiden främst på grund av fördelningen av vatten mellan hav och glaciärer. Den relativa havsnivån på södra Grönland påverkas också till stor del av jordskorpans anpassning till storleken på det grönländska istäcket. I denna studie presenteras en ny strandförUntil recently there have only been a few observations of relative sea-level change from the inner Bredefjord area in southern Greenland. Here a new sea-level curve is presented from the Tasiusaq area based on data mainly from a sediment sequence from a marine embayment. Sea-level changes can be recorded in sediments as changed chemical composition, physical properties and macrofossil content. Iso
This essay focuses on the increasing problems for companies and right-holders with counterfeited and pirated goods in the European Union and the problems for right holders to enforce their IPR rights. Will IPRED1 make a difference and is there really a need for the new Directive of Enforcement 2004/48/EG, or do the sanctions according to the TRIPS Agreement suffice. Further, IPRED2 is a follow up
Foreign trade is an important part in Africa’s internationalization process. In order to assess the entrepreneurial possibilities in Sub Saharan Africa, one can look at firm’s probability of entering the export market. The aim of this paper is to examine the importance of sunk costs of exporting for Sub Saharan African firms. This is done by assessing the importance of past export performance on t
Child sexual abuse (CSA) is a significant public health problem with serious consequences for human and socioeconomic development. In Nicaragua there is a dearth of information about CSA in relation to the health sector. The purpose of this study was to assess the Nicaraguan health sector’s most fundamental capacity to respond to CSA, by way of investigating the conceptions constituted amongst hea
Gender equality (GE) is one of Sweden’s three thematic prioritizations in foreign aid and have so been since 2007. Gender equality is emphasized as important for development and as a question in which Sweden has added value in promoting. The thesis examines what type of gender equality Sweden promotes in development cooperation with nine African countries and how it has changed in the country and
