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BACKGROUND: To inform future preventive measures including repeated vaccinations, we have searched for a clinically useful immune correlate of protection against fatal COVID-19 among nursing homes residents.METHODS: We performed repeated capillary blood sampling with analysis of S-binding IgG in an open cohort of nursing home residents in Sweden. We analyzed immunological and registry data from 16
Background: Postoperative complications (POCs) following resection of colorectal liver metastases (CRLM) are common. The objective of this study was to evaluate risk factors for developing complications and their impact on survival considering prognostic factors of the primary tumor, metastatic pattern and treatment in a well-defined national cohort. Methods: Patients treated with resection for CR
An abundant nuclear phosphoprotein, the La autoantigen, is the first protein to bind all newly synthesized RNA polymerase III transcripts. Binding by the La protein to the 3′ ends of these RNAs stabilizes the nascent transcripts from exonucleolytic degradation. In the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe, the La protein is required for the normal pathway of tRNA maturation
Background: Swimming ability among children in the city of Malmö, Sweden is strongly affected by socioeconomic differences. We investigated to what extent mediating health and lifestyle factors, such as children’s eating, sleeping and physical activity habits, as well as the characteristics of the social and working environment at both school and home, could explain the socioeconomic gradient in s
BACKGROUND: Type 2 diabetes is one of the leading causes of chronic kidney failure, which increases globally and represents a significant threat to public health. People from the Middle East represent one of the largest immigrant groups in Europe today. Despite poor glucose regulation and high risk for early-onset insulin-deficient type 2 diabetes, they have better kidney function and lower rates
Pure hydrocarbons with shape and conjugation properties that can be switched by external stimuli is an intriguing prospect in the design of new responsive materials and single-molecule electronics. Here, we develop an oligomeric [8]annulene-based material that combines a remarkably efficient topological switching upon redox changes with structural simplicity, stability, and straightforward synthes
Evidence for electroweak production of two jets in association with a Zγ pair in s=13 TeV proton–proton collisions at the Large Hadron Collider is presented. The analysis uses data collected by the ATLAS detector in 2015 and 2016 that corresponds to an integrated luminosity of 36.1fb−1. Events that contain a Z boson candidate decaying leptonically into either e+e− or μ+μ−, a photon, and two jets a
A search for heavy neutral Higgs bosons produced in association with one or two b-quarks and decaying to b-quark pairs is presented using 27.8 fb-1 of s=13 TeV proton-proton collision data recorded by the ATLAS detector at the Large Hadron Collider during 2015 and 2016. No evidence of a signal is found. Upper limits on the heavy neutral Higgs boson production cross section times its branching rati
The extensive register infrastructure available for coronavirus disease 2019 surveillance in Scania county, Sweden, makes it possible to classify individual cases with respect to hospitalisation and disease severity, stratify on time since last dose and demographic factors, account for prior infection and extract data for population controls automatically. In the present study, we developed a case
We report on local nowcasting (short-term forecasting) of coronavirus disease (COVID-19) hospitalizations based on syndromic (symptom) data recorded in regular healthcare routines in Östergötland County (population ≈465,000), Sweden, early in the pandemic, when broad laboratory testing was unavailable. Daily nowcasts were supplied to the local healthcare management based on analyses of the time la
AimOur aim is to provide a-priori information on air-quality implications of potential future energy carriers in transportation relevant for sustainability, life cycle and health-impact assessments.MethodologyInformation on air- and climate-pollutant formation from energy carriers is collected in detailed laboratory assessments on heavy-duty combustion engines as well as on non-tailpipe emissions.
This article examines two Swedish TV theater plays from the late 1960s and early 1970s, which both portray the experience of waiting for an abortion. In the early 1960s, a major debate on abortion started in Sweden, which resulted in the creation of a public inquiry into the matter in 1965 and eventually the introduction of abortion on demand in 1975. In the period between 1965 and 1975, attitudes
This study seeks to investigate how stormwater drainage systems in coastal cities respond to climate change in terms of simultaneous sea level rise and rainfall. 7.5 years of recorded rainfall and sea level data in the city of Trelleborg in Sweden were used to generate projections of future climate events based on the emission scenario RCP8.5. Twelve scenarios were formulated to represent rain and
The results of a search for gluino and squark pair production with the pairs decaying via the lightest charginos into a final state consisting of two W bosons, the lightest neutralinos (χ~10), and quarks, are presented: the signal is characterised by the presence of a single charged lepton (e± or μ±) from a W boson decay, jets, and missing transverse momentum. The analysis is performed using 139 f
Objectives To describe the prevalence of comorbidities in a population referred to standardised first-line intervention (patient education and exercise) for hip and knee osteoarthritis (OA), in comparison with the general population. Furthermore, we aimed to evaluate if eventual differences were associated with socioeconomic inequalities. Design Register-based study. Setting Primary healthcare, Sw
Resonant photoelectron spectroscopy (RPES) has been used to probe electronic structure properties of the closed-shell [FeII(CN)6]4− and open-shell [FeIII(CN)6]3− prototype transition metal complexes in aqueous solution. Site-selective Fe 2p (L-edge) RPES mapsprovide new insight into spin-coupling processes at the core-excited metal centers, with autoionization of [FeIII(CN)6]3− showing a dramatic
Processes controlling environmental change in the subarctic Pacific Ocean on millennial to orbital timescales are not well understood. Here we use a 230-kyr sedimentary record from the northwest Pacific Ocean to assess the response of late Pleistocene sediment dynamics to orbital forcing. Combining a source-to-sink perspective based on sedimentological records with climate model reanalysis, we rev
Amyloid fibrils are associated with a number of neurodegenerative diseases, including fibrils of amyloid β42 peptide (Aβ42) in Alzheimer's disease. These fibrils are a source of toxicity to neuronal cells through surface-catalyzed generation of toxic oligomers. Detailed knowledge of the fibril structure may thus facilitate therapeutic development. We use small-angle scattering to provide informati
As global warming is proceeding due to rising greenhouse gas concentrations, the Earth system moves towards climate states that challenge adaptation. Past Earth system states are offering possible modelling systems for the global warming of the coming decades. These include the climate of the mid-Pliocene (∼ 3 Ma), the last interglacial (∼ 129-116 ka) and the mid-Holocene (∼ 6 ka). The simulations
Purpose: To determine and compare the sensitivity, specificity, and proportion of patients eligible for discharge by the Brain Injury Guidelines and the Mild TBI Risk Score in patients with mild traumatic brain injury and concomitant intracranial injury. Methods: Retrospective review of the medical records of adult patients with traumatic intracranial injuries and an initial Glasgow Coma Scale sco
