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Assembly of the mitochondrial respiratory chain requires the coordinated synthesis of mitochondrial and nuclear encoded subunits, redox co-factor acquisition, and correct joining of the subunits to form functional complexes. The conserved Cbp3-Cbp6 chaperone complex binds newly synthesized cytochrome b and supports the ordered acquisition of the heme co-factors. Moreover, it functions as a transla
BACKGROUND: Cerebral palsy (CP) is one of the most common early onset disabilities globally. The causative brain damage in CP is nonprogressive, yet secondary conditions develop and worsen over time. Individuals with CP in Sweden and most of the Nordic countries are systematically followed in the national registry and follow-up program entitled the Cerebral Palsy Follow-Up Program (CPUP). CPUP has
Introduction: The objective of this study was to assess the usefulness of the appropriate use criteria (AUC) for amyloid imaging in an unselected cohort. Methods: We calculated sensitivity and specificity of appropriate use (increased confidence and management change), as defined by Amyloid Imaging Taskforce in the AUC, and other clinical utility outcomes. Furthermore, we compared differences in p
Given the growing use of cerebrospinal fluid (CSF) beta-amyloid (Aß) and tau as biomarkers for early diagnosis of Alzheimer's disease (AD), it is essential that the diagnostic procedures are standardized and the results comparable across different laboratories. Preanalytical factors are reported to be the cause of at least 50% of the total variability. Among them, diurnal variability is a key issu
Grade is an important determinant of progression in non–muscle-invasive bladder cancer. Although the World Health Organization (WHO) 2004/2016 grading system is recommended, other systems such as WHO1973 and WHO1999 are still widely used. Recently, a hybrid (three-tier) system was proposed, separating WHO2004/2016 high grade (HG) into HG/grade 2 (G2) and HG/G3 while maintaining low grade. We asses
The family of methodologies and approaches used and developed by the systemic design community has several characteristics that could play a vital role in supporting collective visioning and concerted action for sustainability transitions. It offers heuristics for bridging scales and domains, and tools for constructing spaces of joint reflection, visioning and decision-making. These methodologies
The idea that tunneling is enhanced by the compression of the donor-acceptor distance has attracted significant interest. In particular, recent studies argued that this proposal is consistent with pressure effects on enzymatic reactions, and that the observed pressure effects support the idea of vibrationally enhanced catalysis. However, a careful analysis of the current works reveals serious inco
Interdisciplinary research and education on human-environment relations has a natural place in many Anglo-American geography and anthropology departments. In Sweden, however, critical scholarship across the socio-natural divide has largely been outsourced to the interdisciplinary field of human ecology. Since the 1970s, Swedish human ecologists have sought to integrate perspectives from the social
At the onset of the pandemic, Brazil’s Federal government approved an emergency basic income to be transferred to a variety of groups that had not earlier received any of the established welfare programs. Its implementation was however riddled with challenges. With a large informal economy, many Brazilian citizens were missing from the Federal Government’s registry and, even if registered, many di
An experimentally based prediction model of road abrasion wear due to studded tyres is available in Sweden and has been found to work well. However, it has not been validated since 2007, and since then road surfaces and tyre design have developed, and the question has arisen regarding the model’s current validity. The abrasion wear model is used in the NORTRIP emission model (NOn-exhaust Road Traf
Due to advances in technology, sampling procedures and short lag times between successive sampling, autocorrelation among the measured data has become common in most applications. Neglecting autocorrelation leads to a poor false alarm performance. In the current paper, the effect of the autocorrelation on the performance of a variable-parameters multivariate single control chart is investigated in
This study investigates the effect of different mixers and the applicability of the mixing energy (ME) concept to dry powder formulations for inhalation. With the aim to step-wise build and expand this concept, adhesive mixtures of 2 % budesonide and lactose carrier were investigated, both with 1 % magnesium stearate (MgSt) added in a ‘coating’ step, and without, the latter referred to as ‘naked’
Rapporten sammanfattar fjärilsinventeringar utförda 2023 inom Biogeografisk uppföljning som drivs av Naturvårdsverket. I fjällområdet inventerades totalt 48 ytor. Sammanlagt noterades 121 högnordiska blåvingar på 25 av 31 inventerade ytor, 26 dvärgpärlemorfjärilar på 9 av 15 ytor och inga fjällsilversmygare på 3 inventerade ytor. Svartfläckig blåvinge observerades på 24 av 49 inventerade lokaler.
Introduction: This article explores how individual-level attitudes towards the exchange of sexual services for payment differ between the Nordic countries. The sparse existing research points to gender and general attitudes towards sexual behavior as powerful predictors of attitudes towards the exchange of sex for payment. However, there are no previous research agendas that attempt to explain var
About a third of all meteorites that fall on Earth today, the stony L-chondrites, originate from a major breakup event in the asteroid belt 466 Ma, in the early Darriwilian. This is the largest asteroid breakup in the past three billion years documented by K-Ar gas-retention ages of recently fallen meteorites. There has been a debate whether the breakup had any effects on Earth’s biota. Based main
Characterising the stop/start walking process of individuals in a crowded and congested space is an important consideration in modelling pedestrian movement. However, the reaction of pedestrians to speed changes, especially to the person in front, has not been fully characterised nor quantified for full adoption in computer models. This study, therefore, explored the different phases of the stop/s
