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During the last few years, recombinant viral vectors derived from adenovirus (Ad), adeno-associated virus (AAV) or lentivirus (LV) have been developed into highly effective vehicles for gene transfer to the adult central nervous system. In recent experiments, in the rat model of Parkinson's disease, all three vector systems have been shown to be effective for long-term delivery of glial cell line-
Substitution of fossil transport fuels with biodiesel and bioethanol can lower greenhouse gas emissions, reduce dependency on oil and strengthen agriculture. This thesis describes, compares and analyses market penetration of biodiesel and bioethanol, as well as the socio-political context for biofuels, in Germany and the United Kingdom. General conclusions for policy makers wanting to design or ch
As growing populations concentrate in urban areas, it has become apparent that many global problems are a cumulative reflection of unsustainable practices at the local level. Correspondingly, there has been an increasing need to monitor and manage sustainable community growth, which includes a balance of environmental, economic, health, and social measures. Throughout the last decade, the communi
Although being promoted as the most eco-friendly form of transportation, the shipping sector currently accounts for around 3 % of global greenhouse gas (GHG) emissions, however, with increasing global trade emissions are expected to increase. Even if energy efficiency gains have been accomplished, the majority of the global fleet continue to run on fossil fuels and the total emissions from ships a
The GMES4Mining R&D project started in summer 2011 with the purpose of supporting management in all phases of a mining cycle. In most states of the European Union, the mines are in phases of operation or reclamation, but in other countries there is an interest in prospecting and exploring new areas for mining. In order to support the implementation of legal responsibilities, GMES4Mining invest
The European Academy of Allergy and Clinical Immunology (EAACI) organized the first European Strategic Forum on Allergic Diseases and Asthma. The main aim was to bring together all relevant stakeholders and decision-makers in the field of allergy, asthma and clinical Immunology around an open debate on contemporary challenges and potential solutions for the next decade. The Strategic Forum was an
The exclusive charmonium production process in pp annihilation with an associated π0 meson pp→J/ψπ0 is studied in the framework of QCD collinear factorization. The feasibility of measuring this reaction through the J/ψ→e+e- decay channel with the AntiProton ANnihilation at DArmstadt (PANDA) experiment is investigated. Simulations on signal reconstruction efficiency as well as the background reject
Sewage dilution and formulated fertilization are cost-effective to avoid sewage-deriving phytotoxicity stress and excess fertilizer application in agricultural sewage irrigation practice. However, it is hard for us to fix the parameters of sewage dilution ratio (SDR) and fertilization formula exactly for the best management of sewage irrigation practice according to those published guidelines. Thi
Seagrasses are important components of marine ecosystem. They are a primary food source for many organisms and provide shelter and nursery areas for many more. Also they stabilize sediments and act as a natural barrier against coastal erosion. But despite their valuable rule, Seagrasses are facing large threats because of human development. The stresses caused by human activities like trawling and
Water for firefighting is often associated with drinking water, due to fire hydrants. Fire hydrants have been installed in towns for a long time and are one of the most common ways for the rescue service to get hold of water for extinguishing fires. This report evaluates the ways that the rescue service uses their water and how the get continuously water to the fire site. Other extinguishing metho
On the 23 September 2020 the European Commission launched the Pact on Migration and Asylum, introducing five legislative proposals, which inter alia aim at ensuring that only people with clear protection needs enter the European Union (EU). To reach this objective, the European Commission introduced a so-called pre-entry phase, consisting of firstly, the proposed screening procedure, a five-day pr
Autonomous robots must operate reliably and safely under uncertain, dynamic conditions over extended periods. To ensure such operational robustness, it is vital that both developers and operators can clearly and verifiably specify functional requirements and safety constraints throughout the robot software lifecycle. My research targets different layers of robot operational safety: early error det
Background – As E.ON’s solar panel business has grown significantly, they are interested in finding new methods of working with inventory management. Currently, it is controlled manually and without any support of structured analytical inventory control methods. Purpose – The purpose of this Master’s Thesis Project is to investigate and suggest a method suitable for inventory control of E.ON’s so
Ultrafast pulse characterization is an ever-growing field of photonics, given the importance of knowing precisely the outcome of ultrafast laser sources and the impossibility to do so with electronics technology. A new approach to the well-established diagnostics technique d-scan has been recently developed in order to expand the capabilities of the d-scan in a single-shot manner. It is known as s
The discrete Fourier transform (DFT) is one of the most important algorithms commonly used in baseband processing. While traditional hardware implemen- tations like the Fast Fourier Transform (FFT) are highly optimized, they heav- ily suffer from the von Neumann bottleneck. To overcome this, performing the computations directly in memory using memristive crossbar arrays is a promising solution. Th
The mechanisms driving the development of immunoglobulin E (IgE) antibody repertoires are a matter of debate. Alternatives to the classical view on antibody development, involving somatic mutation and antigen-driven selection of high-affinity variants in germinal centers, have been proposed. Methods: We have re-analyzed the pattern of mutations in previously isolated and characterized human clonal
