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Angiogenesis is a hallmark of cancer and is now a validated therapeutic target in the clinical setting. Despite the initial success, anti-angiogenic compounds impinging on the vascular endothelial growth factor (VEGF) pathway display limited survival benefits in patients and resistance often develops due to activation of alternative pathways. Thus, finding and validating new targets is highly warr
Regular prophylactic treatment with factor VIII (FVIII) and factor IX (FIX) concentrates in hemophilia A and B, respectively, is introduced in early infancy and has resulted in dramatic improvement of the conditions. Recombinant FVIII and FIX concentrates have been available for > 25 years and have been modified and refined through the years; however, unfortunately frequent intravenous administrat
There is compelling evidence that more diverse ecosystems deliver greater benefits to people, and these ecosystem services have become a key argument for biodiversity conservation. However, it is unclear how much biodiversity is needed to deliver ecosystem services in a cost-effective way. Here we show that, while the contribution of wild bees to crop production is significant, service delivery is
Group B Streptococcus (GBS) is a leading cause of invasive bacterial infections in human newborns. A key GBS virulence factor is its capsular polysaccharide (CPS), displaying terminal sialic acid (Sia) residues which block deposition and activation of complement on the bacterial surface. We recently demonstrated that GBS Sia can bind human CD33-related Sia-recognizing immunoglobulin (Ig) superfami
Lymphocytes from human peripheral blood were separated by Countercurrent distribution (CCD) in a charged aqueous two-phase system composed of Dextran T 500 and polyethylene glycol 6000. Maximal responses to the T-cell mitogens phytohemagglutinin and concanavalin A were detected in a part of the distribution corresponding to the area where the highest percentage of E rosetting cells were seen. Anti
We have characterized 2 distinct mechanisms through which infectious agents may promote platelet adhesion and thrombus formation in flowing blood, thus contributing to the progression of disease. In one case, the process initiates when the integrin alpha(IIb)beta(3) mediates platelet arrest onto immobilized bacterial constituents that have bound plasma fibrinogen. If blood contains antibodies agai
Protein ADP-ribosylation is a reversible post-translational modification that regulates important cellular functions. The identification of modified proteins has proven challenging and has mainly been achieved via enrichment methodologies. Random mutagenesis was used here to develop an engineered Af1521 ADP-ribose binding macro domain protein with 1000-fold increased affinity towards ADP-ribose. T
Centrum för miljö- och klimatforskning, CEC, Miljövetenskaplig Utbildning, Sölvegatan 37, 223 62 Lund http://www.miljovetenskap.lu.se/ Schema MVES04 (tidigare MVEN06) - Miljöövervakning, 15p VT23 ( Obs: alla tider med akademisk kvart! ) Kurstid: 22 mars - 4 juni Kurschef: Adam Kristensson, tel:046-2227645, email: adam.kristensson@nuclear.lu.se Yann Clough, tel: 046-2226831, email: yann.clough@cec.
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/2023-02/MVES04_Schema%202023_v3,%20AMW.pdf - 2026-07-24
PurposeThe purpose of this paper is to explore the environmental impact of logistics service provider (LSP) activities in the light of customer priorities and the fragmentation of the road haulage industry in Europe. It also explores the extent to which LSPs can actually monitor the environmental impact of logistics activities in the supply chain (SC).Design/methodology/approachThe research is bas
Stefan Larsson's Conceptions in the Code contributes invaluably to socio-legal analysis and conceptual metaphor theory. By examining cases of digital copyright, Larsson elucidates the role that metaphor plays when law is accommodating technological change, displaying both conceptual path-dependence as well as non-legislative developments in law. Analyses draw from conceptual studies of property sp
Although Parkinson's disease is a movement disorder, in many patients cognitive dysfunction is an important clinical sign. It is not yet clear whether this is attributable solely to a decrease in dopamine levels, or whether other neurotransmitter systems might be involved as well. In the present study, the importance of the mesocorticolimbic dopamine pathway and a possible convergence with forebra
The trend in contemporary aviation is to enhance safety by implementing a Safety Management System (SMS). This trend has also become a part of the medical rotary industry. As a part of a SMS, Flight Safety Training (FST) is included, which consist of Human factors, Crew Resource Management (CRM) -training and the creation/shaping of attitudes and safety culture. During 2012 a SMS was implemented i
Objectives: Human service workers are at a greater risk for negative work and health-related outcomes due to the highly demanding nature of their work which involves unique stressors such as emotion work and routine interactions with clients. This scoping review synthesizes the current state of literature reporting on the associations of psychosocial safety climate (PSC) with human service workers
In 2010 the center-right Fidesz-Christian Democrat coalition (Fidesz-KDNP) had an unprecedented electoral victory in Hungary. The party won two-thirds of the mandates, allowing the government not only to follow through with their reforms but change laws which require two-third of the votes. After the inauguration they started a fast legislation process, in the frame of this process the constitutio
