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Use of intermittent androgen-deprivation therapy (IADT) in patients with prostate cancer has been evaluated in several studies, in an attempt to delay the development of castration resistance and reduce side-effects associated with ADT. However it is still not clear whether survival is adversely affected in patients treated with IADT. In this review, we explore the available data in an attempt to
The central nervous system (CNS) monitors modifications in metabolic parameters or hormone levels and elicits adaptive responses such as food intake regulation. Particularly, within the hypothalamus, leptin modulates the activity of pro-opiomelanocortin (POMC) neurons which are critical regulators of energy balance. Consistent with a pivotal role of the melanocortin system in the control of energy
Laminins (comprised of alpha, beta, and gamma chains) are heterotrimeric glycoproteins integral to all basement membranes. The function of the lammin alpha5 chain in the developing intestine was defined by analysing laminin alpha5(-/-) mutants and by grafting experiments. We show that lammin alpha5 plays a major role in smooth muscle organisation and differentiation, as excessive folding of intest
Serum response factor (SRF) is a transcription factor that controls the expression of cytoskeletal proteins and immediate early genes in different cell types. Here, we found that SRF expression is restricted to endothelial cells (ECs) of small vessels such as capillaries in the mouse embryo. EC-specific Srf deletion led to aneurysms and hemorrhages from 11.5 days of mouse development (E11.5) and l
RhoH is a small GTPase expressed only in the hematopoietic system. With the use of mice with targeted disruption of the RhoH gene, we demonstrated that RhoH is crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Furthermore, the differentiation and expansion of DN3 and DN4 thymocytes in vitro were severely impaired. These defects corresponded to defective T
Background Transcriptional regulation of the genes in metabolic pathways is a highly successful strategy, which is virtually universal in microorganisms. The lac operon of E. coli is but one example of how enzyme and transporter production can be made conditional on the presence of a nutrient to catabolize. Methodology With a minimalist model of metabolism, cell growth and transcriptional regula
Seminar date: 30th of May 2018 Course: BUSN79 Business Administration; Degree Project in Accounting and Finance Authors: Oskar Lundin & Valdemar Olin Supervisor: Johan Dergård Keywords: Management control, Professional service firms, Clash of Cultures, Motivational theory, Social psychology theory Purpose: The purpose of this study is to contribute to the knowledge of why the performance o
Green Information System (IS) has become an important topic in IT management research and practice in the last few years due to economic opportunities and increasing pressure from stakeholders. However, many private organizations fail to manage their environmental efforts in an adequate manner since they neglect the strategic aspects of this topic. This paper discloses the strategic relevance of G
A university student in China today might find himself or herself taking a “golden course” that blends practical and academic training. The student earns degree credit while gaining direct exposure to industry. The course might even be sponsored by Alibaba, the online retail giant, or another large firm.
Research Purpose: This study aims to provide insight into the consumer perceptions of explicit marketing towards LGBT consumers. Furthermore, it examines the current status of implicit gay marketing Methodology: Triangulation was adopted combining both content analysis and netnography to qualitatively analyse consumer perceptions from three different perspectives. Content analysis was conducted fr
Successful technological transitions require the alignment of technologies, capabilities, infrastructure, and institutions across a wide array of industries and involving many agents. In such processes, synergies and complementarities across different fields of economic activity are crucial. When such complementarities are missing, imbalances emerge, which, in the absence of innovation, may stifle
The paper examines how interjections have been treated in linguistic literature; on what grounds they have been separated from pure response cries; and what their relation is to iconic (onomatopoeic) vocabulary items. Second, the paper examines various English grammars intended for university level students, especially in second language contexts, to see how their treatment of interjections reflec
The implementation of new data regulation has put pressure on organizations to govern their data. However, research on data governance typically focuses on the optimal design of rules and decisionmaking about data. In this paper, we argue that the significant work that goes into responding, when data use is challenged on the basis of regulation, is a legitimate subset of data governance practice.
