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L-DOPA is the gold-standard treatment for Parkinson's disease (PD), but induces troublesome dyskinesia after prolonged treatment. This is associated with the 'false neurotransmitter' conversion of L-DOPA to dopamine by serotonin neurons projecting from the raphe to the dorsal striatum. Reducing their activity by targeting pre-synaptic 5-HT1A receptors should thus be an attractive therapeutic strat
Background. The long-term effect of sustained virologic response (SVR) to antiviral therapy on the risk of developing hepatocellular carcinoma (HCC), liver complications, liver-related death, and overall death in hepatitis C virus (HCV)-infected patients with liver cirrhosis is not fully known. Methods. These risks were evaluated during long-term follow-up in 351 patients with HCV-related cirrhosi
PURPOSEThe LIVESTRONG Young Adult Alliance has conducted a meta-analysis of individual patient data from prospective neoadjuvant chemotherapy osteosarcoma studies and registries to examine the relationships of sex, age, and toxicity on survival. PATIENTS AND METHODSSuitable data sets were identified by a survey of published data reported in PubMed. The final pooled data set comprised 4,838 patient
We determined whether single nucleotide polymorphisms (SNPs) previously associated with diabetogenic traits improve the discriminative power of a type 2 diabetes genetic risk score. Participants (n = 2,751) were genotyped for 73 SNPs previously associated with type 2 diabetes, fasting glucose/insulin concentrations, obesity or lipid levels, from which five genetic risk scores (one for each of the
Background Various genome-wide association studies (GWAS) have been done in ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have been 3500 cases or less. We established the METASTROKE collaboration with the aim of validating associations from previous GWAS and identifying novel genetic associations through meta-analysis of GWAS datasets for ischaemic stroke a
Brevmall Postadress Box 117, 221 00 Lund Besöksadress Kemicentrum, Sölvegatan 39B, Telefon 046-222 9399, 046-222 00 00, E-post Kjell.Josefsson@fs.lu.se Rektor Samfinansiering av indirekta kostnader för forskningsbidrag från National Institutes of Health Bakgrund Universitetet deltar i flera forskningsprojekt finansierade med amerikanska statliga medel, varav den största andelen kommer från Nationa
KURSUTVÄRDERING 2024-06-17 Postadress Besöksadress Telefon E-post Webbadress Box 207 Lilla Gråbrödersgatan 4 046-222 11 26 ujik@jur.lu.se www.jur.lu.se/fristående-kurser 221 00 Lund 222 22 Lund Kursutvärdering för Utvidgad juridisk introduktionskurs, JURF12, VT 2024 Kursansvarig: Per Norberg Övriga lärare: Oskar Wihlstrand, Alisa Fissoun, Julia Nikolausson, Maya Magnusson, Viktor Ejlertsson, Vera
https://www.jur.lu.se/sites/jur.lu.se/files/2025-09/Kursutv%C3%A4rdering%20UJIK%20VT%202024.pdf - 2026-07-16
1 ÖPPET HUS, PROGRAM | 14 MARS 2020, KL 10–15 Öppet hus, program 14 MARS 2020, KL 10–15 Utbildningsmässa AF-BORGEN, STORA SALEN (EN TRAPPA UPP) 10.00–15.00 Träffa studenter från hela universitetet som berättar om Lunds universitets 270 program och 1300 fristående kurser. AF-BORGEN, FOAJÉN UTANFÖR STORA SALEN (EN TRAPPA UPP) 10.00–15.00 Studentlund, som är ett samarbete mellan kårer, nationer och A
https://www.lu.se/sites/www.lu.se/files/web_oppet_hus_program_2020.pdf - 2026-07-16
Introduction Innovations and Sustainability: The Case of Improved Biomass Stoves' Adoption and Use in Tanzania Author: Author: Mwemezi Rwiza Magistratvägen 55 U 111 226 44 LUND Sweden Email: @yahoo.com Submitted for partial fulfillment of the requirements for LUMES, Lund University International Master’s Programme in Environmental Studies and Sustainability Science Supervisor: Sara Brogaard LUCSUS
https://www.lumes.lu.se/sites/lumes.lu.se/files/rwiza_mwemez_0.pdf - 2026-07-16
The contemporary crisis of public discourse is routinely misdiagnosed as a post-truth disregard for facts. This presentation argues that the deeper pathology is a hyper-eikotic environment: a flood of weaponised plausibilities resulting from the historical schism between demonstrable evidence and persuasive reasoning. To navigate this environment, citizens and critics need more than factchecking;
The aim of this study was to evaluate the performance of an artificial intelligence (AI)-based method for automated segmentation of total metabolic tumor volume (TMTV) in 18F-FDG PET/CT scans of patients with lymphoma, using an independent, publicly available benchmark dataset curated and segmented by expert readers in a previously published study. Methods: The AI model, based on a 3-dimensional U
Most retrograde signalling research in plants was performed using Arabidopsis, so an evolutionary perspective on mitochondrial retrograde regulation (MRR) is largely missing. Here, we used phylogenetics to track the evolutionary origins of factors involved in plant MRR. In all cases, the gene families can be traced to ancestral green algae or earlier. However, the specific subfamilies containing f
Polysaccharide degradation by microorganisms is essential in driving global nutrient cycling, developing renewable fuels or chemicals, and promoting human gut health. However, complex polysaccharides are often insoluble, making it challenging to study degradation with soluble enzymes or to measure microbial growth. Several protocols exist to address this challenge, including 3D-printed biomass con
OBJECTIVE: To evaluate a 3-month post-hip arthroscopy rehabilitation program within a randomized controlled trial comparing hip arthroscopy to sham surgery for femoroacetabular impingement syndrome (HIP ARThroscopy International [HIPARTI] trial) by describing exercise adherence, type, and pain; 6-month changes in International Hip Outcome Tool-33 (iHOT-33); and physical impairments and functiona
Gaming disorder (GD) is an addictive disorder with health and social impacts recognized by the World Health Organization. Although the GD treatment evidence base appear to favor cognitive behavioral therapy (CBT), knowledge of its common practice elements is limited. This systematic review critically evaluates CBT interventions for GD, encompassing individual, group, and mixed approaches, to ident
A three-generation resource family was created by crossing two Berkshire grandsires with nine Yorkshire granddams to identify QTL affecting growth, body composition, and meat quality. A total of 512 F2 offspring were evaluated for 11 traits related to growth and body composition and 28 traits related to meat quality. All animals were initially genotyped for 125 markers across the genome. The objec
An important issue in quantitative trait loci (QTL) detection is the use of phenotypic measurement as a dependent variable. Daughter yield deviations (DYDs) as the unit of choice are not available for all traits of interest. The use of de-regressed proofs (DRPFs) of estimated breeding values (EBVs) is an alternative to using daughter yield deviations. The objective of this study was to examine pos
The proportion of unpigmented coat on the trunk was determined from photographs of 38 German Simmental and 627 German Holstein bulls distributed over three generations. All 665 animals were members of 18 Holstein and 3 Simmental half-sib families. A Bayesian estimation of heritability yielded a posterior mean of 0.88 and a standard error of 0.08. A quantitative trait loci (QTL) scan over all chrom
