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Multiplex proteomic platforms provide excellent tools for investigating associations between multiple proteins and disease (e.g., diabetes) with possible prognostic, diagnostic, and therapeutic implications. In this study our aim was to explore novel pathophysiological pathways by examining 92 proteins and their association with incident diabetes in a population-based cohort (146 cases of diabetes
The enhanced vegetation growth by climate warming plays a pivotal role in amplifying the seasonal cycle of atmospheric CO2 at northern lands (>50° N) since 1960s. However, the correlation between vegetation growth, temperature and seasonal amplitude of atmospheric CO2 concentration have become elusive with the slowed increasing trend of vegetation growth and weakened temperature control on CO2 upt
The demand for easily available geographic information is increasing in society. Moreover, knowledge of spatial data infrastructures (SDIs) has increased in many European governmental agencies, in large part because of the implementation of the INSPIRE directive. Many countries, thus, recognise the need to provide more detailed geographic information as network services at the national level. One
Natural methane emissions are noticeably influenced by warming of cold arctic ecosystems and permafrost. An evaluation specifically of Arctic natural methane emissions in relation to our ability to mitigate anthropogenic methane emissions is needed. Here we use empirical scenarios of increases in natural emissions together with maximum technically feasible reductions in anthropogenic emissions to
Lemierre syndrome usually affects otherwise healthy adolescents or young adults and occurs at an overall rate of 1 to 10 cases per million person-years with an estimated fatality rate of 4 to 9%. Diagnostic criteria remain debated and include acute neck/head bacterial infection (often tonsillitis caused by anaerobes at high potential for sepsis and vascular invasion, notably Fusobacterium necropho
The study of molecular dynamics involves observations of the motion of nuclei and electrons. While nuclear motion is usually on the picosecond or femtosecond timescale, attosecond precision is necessary to directly observe the motion of electrons. Ultrashort laser pulses have become established as a viable tool for probing femtosecond dynamics by irradiating the target for only extremely short tim
Permafrost peatlands are biogeochemical hot spots in the Arctic as they store vast amounts of carbon. Permafrost thaw could release part of these long-term immobile carbon stocks as the greenhouse gases (GHGs) carbon dioxide (CO 2
Bryophytes play key roles in the ecological function of a number of major world biomes but remain understudied compared with vascular plants. Little is known about bryophyte responses to different aspects of predicted changes in moisture dynamics with climate change. In this study, CO
The study has developed an interactive mission benefit analysis (MBA) tool that allows instantaneous evaluation of a range of potential mission designs. The designs are evaluated in terms of their constraint on carbon and water fluxes through calibration of a terrestrial bisphere model. The constraint is quantified by methematically rigorous uncertainty propagation in CCDAS. Applying the MBA tool,
Agricultural ecosystems are important for regulating terrestrial hydrological and carbon cycles. Hydrological and carbon processes in agricultural ecosystem models are complex due to interactions between parameters. It is therefore crucial to identify parameter sensitivity before a process-based model is applied for simulations and predicti
The transition to a Circular Economy (CE) requires enabling conditions that remove existing barriers in product life extension and material recovery operations. This contribution investigates barriers to material resource efficiency strategies in the maritime sector in Scandinavia and discusses the potential of policy interventions to enable increased reuse and remanufacturing of ship components.
Depression is one of the most common health problems worldwide but is often undertreated. Internet-delivered cognitive behavioral therapy (ICBT) appears to be an effective treatment option, with the potential to reach a larger proportion of individuals suffering from depression. While many studies have examined the efficacy of ICBT for depression in randomized controlled trials, fewer have focused
To investigate how manufacturing errors affect the gear set, a method is developed to calculate the contact stress of a gear set with pitch and involute incline errors. The method is parametric, and a hybrid model is used to model the gear stiffness. Contact outside the line of action is considered.A numerical example is used to show how manufacturing errors can change the contact pressure and cau
Context: Open tools (e.g., Jenkins, Gerrit and Git) offer a lucrative alternative to commercial tools. Many companies and developers from OSS communities make a collaborative effort to improve the tools. Prior to this study, we developed an empirically based theory for companies’ strategic choices on the development of these tools, based on empirical observations in the telecom domain. Aim: The ai
The ligand Ph2PC6H4(CH2N(Me)CO(Et)) reacts with (bis(diphenylphosphino)butane) (2,5-norbornadiene)rhodium tetrafluoroborate (2a) and (bis(diphenylphosphino)ethane)(2,5-norbornadiene) rhodium tetrafluoroborate (2b) at room temperature in the presence of hydrogen to displace the norbornadiene and give the chelate complexes 3a,b, in which the phosphorus and the oxygen atoms are coordinated to give an
Introduction: We assessed whether modest systemic cooling started within 6 hours of symptom onset improves functional outcome at three months in awake patients with acute ischaemic stroke. Patients and methods: In this European randomised open-label clinical trial with blinded outcome assessment, adult patients with acute ischaemic stroke were randomised to cooling to a target body temperature of
Immunoglobulins or antibodies are the main effector molecules of the B-cell lineage and are encoded by hundreds of variable (V), diversity (D), and joining (J) germline genes, which recombine to generate enormous IG diversity. Recently, high-throughput adaptive immune receptor repertoire sequencing (AIRR-seq) of recombined V-(D)-J genes has offered unprecedented insights into the dynamics of IG re
Current large-scale deforestation poses a threat to ecosystems globally, and imposes substantial and prolonged changes on the hydrological and carbon cycles. The tropical forests of the Amazon and Indonesia are currently undergoing deforestation with catastrophic ecological consequences but widespread deforestation events have occurred several times in Earth's history and these provide lessons for
