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This paper presents a novel approach for the elaboration of an integration strategy for controls and computing systems at large particle accelerator based research facilities. The approach is applied in a specific case study conducted at the world-leading neutron science facility European Spallation Source (ESS). First, an introduction to the term 'integration' in the Systems Engineering literatur
We present the PalCom Object Notation, a textual data representation format for communication between internet of things which support binary and textual data. The format does not require parsing of user data (or the “payload”) and is thus efficient to use also for large binary values such as digital images, audio and video as well as for short textual values. These can be mixed in the same messag
The electric and magnetic polarizabilities of the proton are now well known, owing to Compton scattering measurements on hydrogen targets; however, the neutron polarizabilities are still relatively uncertain, compared to the proton values. To address this problem, a multiinstitutional collaboration has conducted a program of elastic Compton scattering experiments on deuterium at the MAX IV Laborat
In this paper, we propose a class of Generalized Gough-Stewart Platforms (GGSPs) used, as a novel approach, to eliminate the classical isotropic constraint of GSPs (hexapods). GGSPs are based on the standard GSP architecture with additional rotations of the three strut-pairs. Despite the architectural generalization introduced in GGSPs, they do not require much more effort in order to be fabricate
Background and Aims: Small-bowel bleeding is the primary indication for capsule endoscopy (CE). Many experts advocate a "watch-and-wait" policy in negative CE. This meta-analysis examines the odds of rebleeding after negative index CE and the impact on long-term follow-up. Methods: A comprehensive literature search identified articles examining the rebleeding rate after negative CE. Demographic an
Introduction: In Italy the course to become a general practitioner (GP) lasts 3 years and includes both theoretical and practical study. Different from the theoretical part, until recently the practical activity has not been assessed at all. The Emilia Romagna Regional Health Authority has developed a special program called INFORMEG (Management of Tutoring during the Triennial Specific Training in
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The method of angular- and wavelength-dispersive (e.g. two-dimensional) Rietveld refinement is a new and emerging tool for the analysis of neutron diffraction data measured at time-of-flight instruments with large area detectors. Following the approach for one-dimensional refinements (using either scattering angle or time of flight), the first step at each beam time cycle is the calibration of the
The UN Charter describes him or her merely as the “chief administrative officer of the organization,” yet today the Secretary-General is widely recognized as the UN’s chief political representative. How did this transformation and expansion of the office from administrative to political take place? Existing scholarship tends to emphasize the contribution made by Dag Hammarskjöld. This article chal
Normalisation of measured energy use in buildings is important in order to verify their performance in user phase. Two methods for normalisation have been presented in Sweden, static and dynamic normalisation. The static normalisation considers deviating hot water use, indoor temperature, internal loads and external climate. The dynamic normalisation is based on repeated simulation, meaning that t
Human intrahepatic lymphocytes are enriched in CD1d-unrestricted T cells coexpressing NKR. Although the origin of this population remains controversial, it is possible to speculate that the hepatic microenvironment, namely epithelial cells or the cytokine milieu, may play a role in its shaping. IL-15 is constitutively expressed in the liver and has a key role in activation and survival of innate a
The ESS Linac project, phase I, requires 12 long pulse klystron modulators with compact footprint, high pulse power and improved quality both on the output pulse waveform and on the input AC power line. Conventional long pulse modulators are typically based on HV pulse transformers and commonly exhibit poor efficiency, low power density, large footprint and cost, with still limited performance on
A new method to determine the concentration of the free protein S in plasma is described. It is an enzyme-linked ligandsorbent assay (ELSA) which utilises the protein S binding capacity of the natural ligand C4b-binding protein (C4BP) to capture the free protein S from plasma samples. The use of C4BP as ligand in the assay is possible due to the high affinity (Kd = 0.1 nM) of the interaction betwe
BACKGROUND: Protein S is an important regulatory protein of the coagulation cascade. The risk for venous thrombosis associated with protein S deficiency has been uncertain because all previous risk estimates used phenotypic evaluation alone, which can be ambiguous.OBJECTIVE: To quantitate the risk for thrombosis associated with a characterized protein S gene mutation that causes a Gly295-->Val sub
